Ron Milo
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View article: Human biomass movement exceeds the biomass movement of all land animals combined
Human biomass movement exceeds the biomass movement of all land animals combined Open
Earth is teeming with life on the move, shaping ecosystems and human civilizations alike. However, the magnitude of movement by humans and other animals has yet to be assessed holistically. Here we quantify the movement of biomass across a…
View article: Demonstration of bioplastic production from CO2 and formate using the reductive glycine pathway in E. coli
Demonstration of bioplastic production from CO2 and formate using the reductive glycine pathway in E. coli Open
There is a strong need to develop technologies that reduce anthropogenic pollution and the dependence on nonrenewable Earth resources. One way of doing so is by harnessing biological systems for replacing the production of fossil-fuel base…
View article: Vertical farming limitations and potential demonstrated by back-of-the-envelope calculations
Vertical farming limitations and potential demonstrated by back-of-the-envelope calculations Open
Improving food security and reducing the environmental footprint of food production is urgently needed to satisfy the growing global population in a time of climate, biodiversity, and water pressures. Indoor vertical farming is largely ind…
View article: US grass-fed beef is as carbon intensive as industrial beef and ≈10-fold more intensive than common protein-dense alternatives
US grass-fed beef is as carbon intensive as industrial beef and ≈10-fold more intensive than common protein-dense alternatives Open
The high resource intensity of industrial beef in high-income economies has prompted growing interest in alternative, potentially lower environmental impact beef production pathways. Of those, grass feeding is promoted by some as one such …
View article: An Empirically Grounded Data-Driven Methodology for Setting Planetary Boundaries thresholds with A Case Study on Biosphere Integrity
An Empirically Grounded Data-Driven Methodology for Setting Planetary Boundaries thresholds with A Case Study on Biosphere Integrity Open
The planetary boundaries framework is a cornerstone for assessing Earth's resilience and stability, with significant traction in academia and policy-making. However, despite its relevance, many boundaries remain provisional and require rig…
View article: A map of the rubisco biochemical landscape
A map of the rubisco biochemical landscape Open
Rubisco is the primary CO 2 -fixing enzyme of the biosphere 1 , yet it has slow kinetics 2 . The roles of evolution and chemical mechanism in constraining its biochemical function remain debated 3,4 . Engineering efforts aimed at adjusting…
View article: Rubisco is slow across the tree of life
Rubisco is slow across the tree of life Open
Rubisco is the main gateway through which inorganic carbon enters the biosphere, catalyzing the vast majority of carbon fixation on Earth. This pivotal enzyme has long been observed to be kinetically constrained. Yet, this impression is ba…
View article: What fraction of cellular DNA turnover becomes cfDNA?
What fraction of cellular DNA turnover becomes cfDNA? Open
Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells' DNA that reaches the bloodstream is unknown. Here, we …
View article: Author Response: What fraction of cellular DNA turnover becomes cfDNA?
Author Response: What fraction of cellular DNA turnover becomes cfDNA? Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Abstract Cell-free DNA (cfDNA) …
View article: Autotrophic growth of Escherichia coli is achieved by a small number of genetic changes
Autotrophic growth of Escherichia coli is achieved by a small number of genetic changes Open
Synthetic autotrophy is a promising avenue to sustainable bioproduction from CO 2 . Here, we use iterative laboratory evolution to generate several distinct autotrophic strains. Utilising this genetic diversity, we identify that just three…
View article: Author Response: What fraction of cellular DNA turnover becomes cfDNA?
Author Response: What fraction of cellular DNA turnover becomes cfDNA? Open
Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells' DNA that reaches the bloodstream is unknown. Here, we …
View article: What fraction of cellular DNA turnover becomes cfDNA?
What fraction of cellular DNA turnover becomes cfDNA? Open
Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells’ DNA that reaches the bloodstream is unknown. Here, we …
View article: Joint Public Review: Autotrophic growth of E. coli is achieved by a small number of genetic changes
Joint Public Review: Autotrophic growth of E. coli is achieved by a small number of genetic changes Open
Synthetic autotrophy is a promising avenue to sustainable bioproduction from CO2. Here, we use iterative laboratory evolution to generate several distinct autotrophic strains. Utilising this genetic diversity, we identify that just three m…
View article: Author Response: Autotrophic growth of E. coli is achieved by a small number of genetic changes
Author Response: Autotrophic growth of E. coli is achieved by a small number of genetic changes Open
Synthetic autotrophy is a promising avenue to sustainable bioproduction from CO2. Here, we use iterative laboratory evolution to generate several distinct autotrophic strains. Utilising this genetic diversity, we identify that just three m…
View article: Autotrophic growth of E. coli is achieved by a small number of genetic changes
Autotrophic growth of E. coli is achieved by a small number of genetic changes Open
Synthetic autotrophy is a promising avenue to sustainable bioproduction from CO2. Here, we use iterative laboratory evolution to generate several distinct autotrophic strains. Utilising this genetic diversity, we identify that just three m…
View article: Joint Public Review: What fraction of cellular DNA turnover becomes cfDNA?
Joint Public Review: What fraction of cellular DNA turnover becomes cfDNA? Open
Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells' DNA that reaches the bloodstream is unknown. Here, we …
View article: Reply to Santini et al.: Total population reports are necessary for global biomass estimation of wild mammals
Reply to Santini et al.: Total population reports are necessary for global biomass estimation of wild mammals Open
Micro-nano plastics originating from the prevalent usage of plastics have raised increasingly alarming concerns worldwide. However, there remains a fundamental knowledge gap in nanoplastics because of the lack of effective analytical ...Pl…
View article: Author Response: Autotrophic growth of E. coli is achieved by a small number of genetic changes
Author Response: Autotrophic growth of E. coli is achieved by a small number of genetic changes Open
Synthetic autotrophy is a promising avenue to sustainable bioproduction from CO2. Here, we use iterative laboratory evolution to generate several distinct autotrophic strains. Utilising this genetic diversity, we identify that just three m…
View article: Autotrophic growth of E. coli is achieved by a small number of genetic changes
Autotrophic growth of E. coli is achieved by a small number of genetic changes Open
Synthetic autotrophy is a promising avenue to sustainable bioproduction from CO2. Here, we use iterative laboratory evolution to generate several distinct autotrophic strains. Utilising this genetic diversity, we identify that just three m…
View article: Demonstration of Bioplastic Production from CO<sub>2</sub>and Formate using the Reductive Glycine Pathway in<i>E. coli</i>
Demonstration of Bioplastic Production from CO<sub>2</sub>and Formate using the Reductive Glycine Pathway in<i>E. coli</i> Open
There is a strong need to develop technologies that reduce anthropogenic pollution and the dependence on nonrenewable Earth resources. One way of doing so is by harnessing biological systems for replacing the production of fossil-fuel base…
View article: The total mass, number, and distribution of immune cells in the human body
The total mass, number, and distribution of immune cells in the human body Open
The immune system is a complex network of cells with critical functions in health and disease. However, a comprehensive census of the cells comprising the immune system is lacking. Here, we estimated the abundance of the primary immune cel…
View article: A map of the rubisco biochemical landscape
A map of the rubisco biochemical landscape Open
Rubisco is the primary CO 2 fixing enzyme of the biosphere yet has slow kinetics. The roles of evolution and chemical mechanism in constraining the sequence landscape of rubisco remain debated. In order to map sequence to function, we deve…