Ron Refaeli
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View article: Astrocytic Activation Completely Corrects Memory Performance in an Alzheimer’s Disease Model
Astrocytic Activation Completely Corrects Memory Performance in an Alzheimer’s Disease Model Open
Neural and glial dysfunction are thought to underlie memory impairments in Alzheimer’s disease (AD). Conversely, astrocytes are known to play a central role in the healthy brain, and their activation has been shown to enhance memory. To te…
View article: Computational modeling of the relationship between morphological heterogeneity and functional responses in mouse hippocampal astrocytes
Computational modeling of the relationship between morphological heterogeneity and functional responses in mouse hippocampal astrocytes Open
Recent studies indicate that astrocytes show heterogeneity in morphology and physiological function. They integrate synaptic signals and release calcium in reaction to active neurons. These calcium signals are not yet fully understood as t…
View article: Astrocytes Control Recent and Remote Memory Strength by Affecting the Recruitment of the CA1→ACC Projection to Engrams
Astrocytes Control Recent and Remote Memory Strength by Affecting the Recruitment of the CA1→ACC Projection to Engrams Open
Recent and remote memories are encoded throughout the brain in ‘Engrams’: cell ensembles formed during acquisition, and upon their reactivation, a specific memory can be recalled. The maturation of engrams from recent to remote time points…
View article: Engram stability and maturation during systems consolidation
Engram stability and maturation during systems consolidation Open
Remote memories play an important role in how we perceive the world, and they are rooted throughout the brain in "engrams": ensembles of cells that are formed during acquisition. Upon their reactivation, a specific memory can be recalled.1…
View article: Engram Stability and Maturation During Systems Consolidation Underlies Remote Memory
Engram Stability and Maturation During Systems Consolidation Underlies Remote Memory Open
Remote memories play an important role in how we perceive the world and are rooted in ensembles in the CA1 and ACC, however the evolution of these components during systems consolidation has not yet been comprehensively addressed. By apply…
View article: Cover Image, Volume 69, Issue 10
Cover Image, Volume 69, Issue 10 Open
Cover Illustration: Automated detection and reconstruction of astrocytic domain (cyan) in 3D volume of CA1 that was injected with a viral vector to induce the expression of tdTomato (purple) in astrocytes, and then made transparent by CLAR…
View article: Features of hippocampal astrocytic domains and their spatial relation to excitatory and inhibitory neurons
Features of hippocampal astrocytic domains and their spatial relation to excitatory and inhibitory neurons Open
The mounting evidence for the involvement of astrocytes in neuronal circuits function and behavior stands in stark contrast to the lack of detailed anatomical description of these cells and the neurons in their domains. To fill this void, …
View article: Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests
Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests Open
Adaptive sample pooling for SARS-CoV-2 testing based on positivity rates spares 76% of test reactions without compromising specificity or sensitivity.
View article: Features Of Hippocampal Astrocytic Domains And Their Spatial Relation To Excitatory And Inhibitory Neurons
Features Of Hippocampal Astrocytic Domains And Their Spatial Relation To Excitatory And Inhibitory Neurons Open
SUMMARY The mounting evidence for the involvement of astrocytes in neuronal circuits function and behavior stands in stark contrast to the lack of detailed anatomical description of these cells and the neurons in their domains. To fill thi…
View article: The Star Cells of Memory—Astrocytes
The Star Cells of Memory—Astrocytes Open
Everything we do (sense, move, feel, remember…) relies on the activity of neurons in the brain, the connections between them and their ability to change the strength of these connections. Astrocytes are a different type of brain cells prev…