Explanipedia

What fraction of cellular DNA turnover becomes cfDNA? Open

Ron Sender, Εlad Noor, Ron Milo, Yuval Dor · 2024

Biology

Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells' DNA that reaches the bloodstream is unknown. Here, we …

Author Response: What fraction of cellular DNA turnover becomes cfDNA? Open

Ron Sender, Εlad Noor, Ron Milo, Yuval Dor · 2024

Chemistry Biology

Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Abstract Cell-free DNA (cfDNA) …

Author Response: What fraction of cellular DNA turnover becomes cfDNA? Open

Ron Sender, Εlad Noor, Ron Milo, Yuval Dor · 2024

Chemistry Biology

Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells' DNA that reaches the bloodstream is unknown. Here, we …

What fraction of cellular DNA turnover becomes cfDNA? Open

Ron Sender, Εlad Noor, Ron Milo, Yuval Dor · 2024

Biology

Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells’ DNA that reaches the bloodstream is unknown. Here, we …

Joint Public Review: What fraction of cellular DNA turnover becomes cfDNA? Open

Ron Sender, Εlad Noor, Ron Milo, Yuval Dor · 2024

Computer science Biology Chemistry

Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells' DNA that reaches the bloodstream is unknown. Here, we …

The total mass, number, and distribution of immune cells in the human body Open

Ron Sender, Yarden Weiss, Yoav Navon, Idan Milo, Nofar Azulay , et al. · 2023

Biology Mathematics

The immune system is a complex network of cells with critical functions in health and disease. However, a comprehensive census of the cells comprising the immune system is lacking. Here, we estimated the abundance of the primary immune cel…

What fraction of cellular DNA turnover becomes cfDNA? Open

Ron Sender, Εlad Noor, Ron Milo, Yuval Dor · 2023

Biology Chemistry

Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells' DNA that reaches the bloodstream is unknown. Here, we …

What fraction of cellular DNA turnover becomes cfDNA? Open

Ron Sender, Εlad Noor, Ron Milo, Yuval Dor · 2023

Biology

Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells’ DNA that reaches the bloodstream is unknown. Here we i…

What fraction of cellular DNA turnover becomes cfDNA? Open

Ron Sender, Εlad Noor, Ron Milo, Yuval Dor · 2023

Biology

Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells’ DNA that reaches the bloodstream is unknown. Here, we …

Inferring the differences in incubation-period and generation-interval distributions of the Delta and Omicron variants of SARS-CoV-2 Open

Sang Woo Park, Kaiyuan Sun, Sam Abbott, Ron Sender, Yinon M. Bar‐On , et al. · 2023

Biology Medicine Mathematics

Estimating the differences in the incubation-period, serial-interval, and generation-interval distributions of SARS-CoV-2 variants is critical to understanding their transmission. However, the impact of epidemic dynamics is often neglected…

The global biomass of wild mammals Open

Lior Greenspoon, Eyal Krieger, Ron Sender, Yuval Rosenberg, Yinon M. Bar‐On , et al. · 2023

Biology

Wild mammals are icons of conservation efforts, yet there is no rigorous estimate available for their overall global biomass. Biomass as a metric allows us to compare species with very different body sizes, and can serve as an indicator of…

The unmitigated profile of COVID-19 infectiousness Open

Ron Sender, Yinon M. Bar‐On, Sang Woo Park, Εlad Noor, Jonathan Dushoff , et al. · 2022

Biology Geography Computer science

Quantifying the temporal dynamics of infectiousness of individuals infected with SARS-CoV-2 is crucial for understanding the spread of COVID-19 and for evaluating the effectiveness of mitigation strategies. Many studies have estimated the …

Inferring the differences in incubation-period and generation-interval distributions of the Delta and Omicron variants of SARS-CoV-2 Open

Sang Woo Park, Kaiyuan Sun, Sam Abbott, Ron Sender, Yinon M. Bar‐On , et al. · 2022

Biology Mathematics Physics

Estimating the differences in the incubation-period, serial-interval, and generation-interval distributions of SARS-CoV-2 variants is critical to understanding their transmission and control. However, the impact of epidemic dynamics is oft…

The unmitigated profile of COVID-19 infectiousness Open

Ron Sender, Yinon M. Bar‐On, Sang Woo Park, Εlad Noor, Jonathan Dushoff , et al. · 2021

Geography Computer science Mathematics

Quantifying the temporal dynamics of infectiousness of individuals infected with SARS-CoV-2 is crucial for understanding the spread of the COVID-19 pandemic and for analyzing the effectiveness of different mitigation strategies. Many studi…

The total number and mass of SARS-CoV-2 virions Open

Ron Sender, Yinon M. Bar‐On, Shmuel Gleizer, Biana Bernshtein, Avi I. Flamholz , et al. · 2021

Biology Medicine

Significance Knowing the absolute numbers of virions in an infection promotes better understanding of disease dynamics and response of the immune system. Here we use current knowledge on the concentrations of virions in infected individual…

The total number and mass of SARS-CoV-2 virions Open

Ron Sender, Yinon M. Bar‐On, Shmuel Gleizer, Biana Bernsthein, Avi I. Flamholz , et al. · 2020

Biology Medicine

Quantitatively describing the time course of the SARS-CoV-2 infection within an infected individual is important for understanding the current global pandemic and possible ways to combat it. Here we integrate the best current knowledge abo…

Quantitative clarification of key questions about COVID-19 epidemiology Open

Yinon M. Bar‐On, Ron Sender, Avi I. Flamholz, Bob Phillips, Ron Milo · 2020

Computer science Medicine

Modeling the spread of COVID-19 is crucial for informing public health policy. All models for COVID-19 epidemiology rely on parameters describing the dynamics of the infection process. The meanings of epidemiological parameters like R_0, R…

A quantitative compendium of COVID-19 epidemiology Open

Yinon M. Bar‐On, Ron Sender, Avi I. Flamholz, Rob Phillips, Ron Milo · 2020

Computer science Geography Medicine

Accurate numbers are needed to understand and predict viral dynamics. Curation of high-quality literature values for the infectious period duration or household secondary attack rate, for example, is especially pressing currently because t…

Revised Estimates for the Number of Human and Bacteria Cells in the Body Open

Ron Sender, Shai Fuchs, Ron Milo · 2016

Biology

Reported values in the literature on the number of cells in the body differ by orders of magnitude and are very seldom supported by any measurements or calculations. Here, we integrate the most up-to-date information on the number of human…

Revised estimates for the number of human and bacteria cells in the body Open

Ron Sender, Shai Fuchs, Ron Milo · 2016

Biology

We critically revisit the “common knowledge” that bacteria outnumber human cells by a ratio of at least 10:1 in the human body. We found the total number of bacteria in the “reference man” to be 3.9·10 13 , with an uncertainty (SEM) of 25%…

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