Ron Sinclair
YOU?
Author Swipe
View article: Somatic evolution following cancer treatment in normal tissue
Somatic evolution following cancer treatment in normal tissue Open
The extent to which exogenous sources, including cancer treatment, contribute to somatic evolution in normal tissue remains unclear. Here we used high-depth duplex sequencing 1 (more than 30,000× coverage) to analyse 168 cancer-free sample…
View article: Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma
Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma Open
Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflec…
View article: 60 Storytelling in advance care planning: a randomised controlled trial in the Australian home care setting
60 Storytelling in advance care planning: a randomised controlled trial in the Australian home care setting Open
View article: Top 10 consumer and healthcare professional priorities for research in the field of quality use of medicines in people living with dementia
Top 10 consumer and healthcare professional priorities for research in the field of quality use of medicines in people living with dementia Open
Background People living with Alzheimer's disease and other types of dementia are vulnerable to medicine-related problems. More research is needed to support achieving quality use of medicines in people living with dementia. Objective To d…
View article: Enhanced Advance care planning and life Review Longitudinal Intervention (EARLI): Protocol for a cluster randomized controlled cross-over trial of life story work and facilitated advance care planning among older Australian adults in community settings
Enhanced Advance care planning and life Review Longitudinal Intervention (EARLI): Protocol for a cluster randomized controlled cross-over trial of life story work and facilitated advance care planning among older Australian adults in community settings Open
Background: Advance care planning (ACP) is potentially helpful for older adults, however, the rate of uptake in community aged care settings is low. Previous pilot studies suggest that holistic, person-centered ACP approaches may be effect…
View article: Transition for people with dementia from day respite services to permanent residential care: a realist synthesis
Transition for people with dementia from day respite services to permanent residential care: a realist synthesis Open
View article: Surveillance of Wildlife Viruses: Insights from South Australia’s Monitoring of Rabbit Haemorrhagic Disease Virus (RHDV GI.1 and GI.2)
Surveillance of Wildlife Viruses: Insights from South Australia’s Monitoring of Rabbit Haemorrhagic Disease Virus (RHDV GI.1 and GI.2) Open
Surveillance of wildlife virus impacts can be passive or active. Both approaches have their strengths and weaknesses, especially regarding cost and knowledge that can be gained. Monitoring of rabbit haemorrhagic disease virus (GI.1 and GI.…
View article: Factors Associated with Advance Care Planning Engagement Among Community‐Dwelling Older Adults: A Cross‐Sectional Study
Factors Associated with Advance Care Planning Engagement Among Community‐Dwelling Older Adults: A Cross‐Sectional Study Open
Aim To explore the associations between depression, anxiety, decisional conflict and advance care planning engagement and the potential mediating role of decisional conflict in the associations between depression, anxiety and advance care …
View article: Validating care and treatment scenarios for measuring decisional conflict regarding future care preferences among older adults
Validating care and treatment scenarios for measuring decisional conflict regarding future care preferences among older adults Open
Objective Decisional conflict is used increasingly as an outcome measure in advance care planning (ACP) studies. When the Decisional Conflict Scale (DCS) is used in anticipatory decision‐making contexts, the scale is typically tethered to …
View article: Enhanced Advance Care Planning and Life Review Longitudinal Intervention (Earli): Protocol for a Cluster Randomized Controlled Cross-Over Trial of Life Story Work and Facilitated Advance Care Planning Among Older Australian Adults in Community Settings
Enhanced Advance Care Planning and Life Review Longitudinal Intervention (Earli): Protocol for a Cluster Randomized Controlled Cross-Over Trial of Life Story Work and Facilitated Advance Care Planning Among Older Australian Adults in Community Settings Open
View article: Enhanced Advance Care Planning and Life Review Longitudinal Intervention (EARLI): Protocol for a Cluster Randomized Controlled Cross-over Trial of Life Story Work and Facilitated Advance Care Planning Among Older Australian Adults in Community Settings
Enhanced Advance Care Planning and Life Review Longitudinal Intervention (EARLI): Protocol for a Cluster Randomized Controlled Cross-over Trial of Life Story Work and Facilitated Advance Care Planning Among Older Australian Adults in Community Settings Open
View article: The cultural adaptation of iSupport program: Experiences from Australia, Brazil, Indonesia, New Zealand and Qatar
The cultural adaptation of iSupport program: Experiences from Australia, Brazil, Indonesia, New Zealand and Qatar Open
Background To support informal dementia carers, the World Health Organization (WHO) developed ‘iSupport for Dementia’ online skills training program, culturally adaptable to local contexts. Several WHO Member States are adapting the progra…
View article: Copy number architectures define treatment-mediated selection of lethal prostate cancer clones
Copy number architectures define treatment-mediated selection of lethal prostate cancer clones Open
View article: Transition for people with dementia from day respite services to permanent residential care: a realist synthesis
Transition for people with dementia from day respite services to permanent residential care: a realist synthesis Open
Respite and permanent transition to residential aged care are processes that are designed to support preferences and needs of people living with dementia and their carers as the disease progresses. These services are highly variable in acc…
View article: PP21.001 Cross-cultural validation of serious illness scenarios and preferences for life sustaining treatments for use in advance care planning studies
PP21.001 Cross-cultural validation of serious illness scenarios and preferences for life sustaining treatments for use in advance care planning studies Open
Background Decisional conflict is a commonly used measure in studies of medical decision-making. However in advance care planning (ACP) studies, which often focus on anticipatory decisions, using the Decisional Conflict Scale (DCS) require…
View article: Consumer and Healthcare Professional Led Priority Setting for Quality Use of Medicines in People with Dementia: Gathering Unanswered Research Questions
Consumer and Healthcare Professional Led Priority Setting for Quality Use of Medicines in People with Dementia: Gathering Unanswered Research Questions Open
Background: Historically, research questions have been posed by the pharmaceutical industry or researchers, with little involvement of consumers and healthcare professionals. Objective: To determine what questions about medicine use are im…
View article: Creating ‘Partnership in iSupport program’ to optimise family carers’ impact on dementia care: a randomised controlled trial protocol
Creating ‘Partnership in iSupport program’ to optimise family carers’ impact on dementia care: a randomised controlled trial protocol Open
Background The majority of people with dementia are cared for by their family members. However, family carers are often unprepared for their caring roles, receiving less education and support compared with professional carers. The conseque…
View article: Allele-informed copy number evaluation of plasma DNA samples from metastatic prostate cancer patients: the PCF_SELECT consortium assay
Allele-informed copy number evaluation of plasma DNA samples from metastatic prostate cancer patients: the PCF_SELECT consortium assay Open
Sequencing of cell-free DNA (cfDNA) in cancer patients’ plasma offers a minimally-invasive solution to detect tumor cell genomic alterations to aid real-time clinical decision-making. The reliability of copy number detection decreases at l…
View article: Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma Open
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the mechanism underpinning therap…
View article: Empowering Dementia Carers With an iSupport Virtual Assistant (e-DiVA) in Asia-Pacific Regional Countries: Protocol for a Pilot Multisite Randomized Controlled Trial
Empowering Dementia Carers With an iSupport Virtual Assistant (e-DiVA) in Asia-Pacific Regional Countries: Protocol for a Pilot Multisite Randomized Controlled Trial Open
Background Dementia is a global public health priority with an estimated prevalence of 150 million by 2050, nearly two-thirds of whom will live in the Asia-Pacific region. Dementia creates significant care needs for people with the disease…
View article: Empowering Dementia Carers With an iSupport Virtual Assistant (e-DiVA) in Asia-Pacific Regional Countries: Protocol for a Pilot Multisite Randomized Controlled Trial (Preprint)
Empowering Dementia Carers With an iSupport Virtual Assistant (e-DiVA) in Asia-Pacific Regional Countries: Protocol for a Pilot Multisite Randomized Controlled Trial (Preprint) Open
BACKGROUND Dementia is a global public health priority with an estimated prevalence of 150 million by 2050, nearly two-thirds of whom will live in the Asia-Pacific region. Dementia creates significant care needs for people with the diseas…
View article: Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue
Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue Open
View article: Previous exposure to myxoma virus reduces survival of European rabbits during outbreaks of rabbit haemorrhagic disease
Previous exposure to myxoma virus reduces survival of European rabbits during outbreaks of rabbit haemorrhagic disease Open
Exploiting synergies among diseases or parasites could increase the efficacy of biological control of invasive species. In Australia, two viruses were introduced to control European rabbits Oryctolagus cuniculus : myxoma virus in 1950 and …
View article: Selection on Mitochondrial Variants Occurs between and within Individuals in an Expanding Invasion
Selection on Mitochondrial Variants Occurs between and within Individuals in an Expanding Invasion Open
Mitochondria are critical for life, yet their underlying evolutionary biology is poorly understood. In particular, little is known about interaction between two levels of evolution: between individuals and within individuals (competition b…
View article: Is there evidence of selection in the dopamine receptor D4 gene in Australian invasive starling populations?
Is there evidence of selection in the dopamine receptor D4 gene in Australian invasive starling populations? Open
Although population genetic theory is largely based on the premise that loci under study are selectively neutral, it has been acknowledged that the study of DNA sequence data under the influence of selection can be useful. In some circumst…
View article: Timing and severity of immunizing diseases in rabbits is controlled by seasonal matching of host and pathogen dynamics
Timing and severity of immunizing diseases in rabbits is controlled by seasonal matching of host and pathogen dynamics Open
Infectious diseases can exert a strong influence on the dynamics of host populations, but it remains unclear why such disease-mediated control only occurs under particular environmental conditions. We used 16 years of detailed field data o…