Explanipedia

SUN-294 Urinary Bladder Paraganglioma With POT1 and RECQL4 Mutations Almost Missed by Ga-68 DOTATATE PET/CT Open

Vidhu Vadini, Andrés Matoso, Nirmish Singla, Ronadip R. Banerjee, Amir H. Hamrahian , et al. · 2025

Disclosure: V. Vadini: None. A. Matoso: None. N. Singla: None. R.R. Banerjee: None. A.H. Hamrahian: None. S.M. Chen Cardenas: None. Background: Urinary bladder paragangliomas (UBPGL) are exceedingly rare, constituting <1% of all paragan…

SUN-216 Prolactin Regulates Chromatin Accessibility in Pancreatic Β-Cells Open

Nelmari Ruiz Otero, Jin‐Yong Chung, Ronadip R. Banerjee · 2025

Disclosure: N. Ruiz Otero: None. J. Chung: None. R.R. Banerjee: None. Maternal pancreatic β-cells undergo functional and structural changes to adapt to increased metabolic demands during pregnancy. Lactogen signaling via the prolactin rece…

c-Jun regulates postpartum β-cell apoptosis and survival downstream of prolactin signaling Open

Jin‐Yong Chung, Nelmari Ruiz-Otero, Ronadip R. Banerjee · 2025

Objective Pregnancy and postpartum states drive dynamic expansion and regression of maternal β-cell mass. Little is known about what regulates postpartum regression. We recently profiled murine islets at different time points from late ges…

A Visual Diagnosis: Lipodystrophy Open

Salman Zahoor Bhat, Rebecca J. Brown, Ronadip R. Banerjee · 2023

Lipodystrophy syndromes are rare metabolic disorders characterized by local or generalized loss of adipose tissue, resulting in insulin resistance, dyslipidemia, and cosmetic disfiguration. The lipodystrophic phenotype is highly variable, …

Pancreatic islet cell type–specific transcriptomic changes during pregnancy and postpartum Open

Jin‐Yong Chung, Yongjie Ma, Dingguo Zhang, Hayden Bickerton, Eric Stokes , et al. · 2023

Pancreatic β-cell mass expands during pregnancy and regresses in the postpartum period in conjunction with dynamic metabolic demands on maternal glucose homeostasis. To understand transcriptional changes driving these adaptations in β-cell…

Localized cytotoxic T cell–associated antigen 4 and antioxidant islet encapsulation alters macrophage signaling and induces regulatory and anergic T cells to enhance allograft survival Open

Jessie M. Barra, Veronika Kozlovskaya, KaLia Burnette, Ronadip R. Banerjee, Christopher A. Fraker , et al. · 2023

Editorial: Staving off gestational diabetes: Pancreatic islet adaptations and the extrinsic signals that drive them Open

James E. Bowe, Carol Huang, H. Henry Dong, Ronadip R. Banerjee · 2022

EDITORIAL article Front. Endocrinol., 23 November 2022Sec. Diabetes: Molecular Mechanisms https://doi.org/10.3389/fendo.2022.1056352

Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors Open

Angela M. Carter, Nilesh Kumar, Brendon Herring, Chunfeng Tan, Rachael Guenter , et al. · 2021

Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis Open

Eliana Toren, KaLia Burnette, Ronadip R. Banerjee, Chad S. Hunter, Hubert M. Tse · 2021

Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to insulin insufficiency and hyperglycemia, with patients eventua…

Very Low Vitamin D in a Patient With a Novel Pathogenic Variant in the <i>GC</i> Gene That Encodes Vitamin D-Binding Protein Open

Ronadip R. Banerjee, Tara Spence, Stuart J. Frank, Raj Pandian, Andrew N. Hoofnagle , et al. · 2021

Circulating plasma vitamin D metabolites are highly bound to vitamin D-binding protein (DBP), also known as group-specific component or Gc-globulin. DBP, encoded by the GC gene, is a member of the albumin family of globular serum transport…

Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors Open

Angela M. Carter, Nilesh Kumar, Brendon Herring, Chunfeng Tan, Racheal Guenter , et al. · 2021

Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous population of neoplasms that arise from hormone-secreting islet cells of the pancreas and have increased markedly in incidence over the past four decades. Non-functional PanNET…

Lactation improves pancreatic β cell mass and function through serotonin production Open

Joon Ho Moon, Hyeongseok Kim, Hyunki Kim, Jungsun Park, Wonsuk Choi , et al. · 2020

Lactation benefits women’s metabolic health by improving pancreatic β cell mass and function through serotonin production in β cells.

MON-372 Treatment-Resistant Vitamin D Deficiency: Is It a Vitamin D Binding Protein Issue? Open

Sirisha Reddy Thambuluru, Imran Unal, Stuart J. Frank, Amy H. Warriner, Fernando Ovalle , et al. · 2020

Introduction Vitamin D is present in free and bound forms; the bound form is complexed mainly to vitamin D binding protein (DBP). Vitamin D levels are affected by age, pregnancy, liver disease, obesity, and DBP mutations. We report a patie…

SAT-361 RISK FACTORS ASSESSMENT IN PROGRESSION OF SNAKE VENOM INDUCED ACUTE KIDNEY INJURY TO CHRONIC KIDNEY DISEASE Open

P Mukhopadhyay, Ronadip R. Banerjee · 2020

Snake bite, an occupational health hazard, causing high mortality and morbidity in tropical developing countries. Snake venom induced acute kidney injury (SAKI) is one of the major cause of high death rate and long term consequences. Howev…

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation Open

Joon Ho Moon, Yeong Gi Kim, Kyuho Kim, Sho Osonoi, Shuang Wang , et al. · 2019

A sufficient β-cell mass is crucial for preventing diabetes, and perinatal β-cell proliferation is important in determining the adult β-cell mass. However, it is not yet known how perinatal β-cell proliferation is regulated. Here, we repor…

SAT-163 Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets Open

Mark E. Pepin, Adam R. Wende, Ronadip R. Banerjee · 2019

Pancreatic β-cells undergo profound hyperplasia during pregnancy to maintain maternal euglycemia. Failure to reprogram β-cells into a more replicative state has been found to underlie susceptibility to gestational diabetes (GDM). Our labor…

Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets Open

Mark E. Pepin, Hayden Bickerton, Maigen Bethea, Chad S. Hunter, Adam R. Wende , et al. · 2019

Pancreatic β-cells undergo profound hyperplasia during pregnancy to maintain maternal euglycemia. Failure to reprogram β-cells into a more replicative state has been found to underlie susceptibility to gestational diabetes mellitus (GDM). …

Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets Open

Mark E. Pepin, Adam R. Wende, Ronadip R. Banerjee · 2018

Pancreatic β-cells undergo profound hyperplasia during pregnancy to maintain maternal euglycemia. Failure to reprogram β-cells into a more replicative state has been found to underlie susceptibility to gestational diabetes mellitus (GDM). …

Differential tissue response to growth hormone in mice Open

Ryan Berry, Graham R. McGinnis, Ronadip R. Banerjee, Martin E. Young, Stuart J. Frank · 2018

Growth hormone (GH) has been shown to act directly on multiple tissues throughout the body. Historically, it was believed that GH acted directly in the liver and only indirectly in other tissues via insulin‐like growth hormone 1 (IGF‐1). D…

ASF1B chaperones histone 3.3 to the <b>β</b>-cell cycle dance Open

Ronadip R. Banerjee, Sushant Bhatnagar · 2016

This article refers to:Histone chaperone ASF1B promotes human β-cell proliferation via recruitment of histone H3.3

Ectopic and visceral fat deposition in lean and obese type 2 diabetes patients Open

Eylem Levelt, Michael Pavlides, Ronadip R. Banerjee, Masliza Mahmod, Matt Kelly , et al. · 2016

Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells Open

Ronadip R. Banerjee, Holly A. Cyphert, Emily M. Walker, Harini Chakravarthy, Heshan Peiris , et al. · 2016

β-Cell proliferation and expansion during pregnancy are crucial for maintaining euglycemia in response to increased metabolic demands placed on the mother. Prolactin and placental lactogen signal through the prolactin receptor (PRLR) and c…

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