Ronald Bleday
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Capturing Patient Reported Outcomes Following Treatment of Benign Anorectal Disease Requires Significant Surgeon Commitment: Do Surgeons Really Want to Know? Open
Background: The long-term effects of anorectal disease management on patients’ quality of life remains poorly understood. Objectives: This study aimed to evaluate the self-reported impact of both medical and surgical interventions for beni…
VentX promotes tumor specific immunity and efficacy of immune checkpoint inhibitors Open
Immune suppression within tumor microenvironments (TME) have been implicated in limited efficacy of immune check point inhibitors (ICIs) against solid tumors. Down-regulated VentX expression in tumor associated macrophages (TAMs) underlies…
Evaluation of interdisciplinary care pathway implementation in older elective surgery patients Open
Background The American College of Surgeons Geriatric Surgery Verification Program outlines best practices for surgical care in older adults. These recommendations have guided institutions to create workflows to better support needs specif…
View article: Spatially organized multicellular immune hubs in human colorectal cancer
Spatially organized multicellular immune hubs in human colorectal cancer Open
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we tr…
View article: Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer
Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer Open
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we tr…
View article: Enhanced recovery after surgery pathway in patients with soft tissue sarcoma
Enhanced recovery after surgery pathway in patients with soft tissue sarcoma Open
Background Patients undergoing surgery for soft tissue sarcoma have high morbidity rates, particularly after preoperative radiation therapy (RT). An enhanced recovery after surgery (ERAS) programme may improve perioperative outcomes in abd…
A multi-center analysis of cumulative inpatient opioid use in colorectal surgery patients Open
We identified risk factors for high inpatient use that can be used to identify patients that may benefit from opioid sparing strategies. Furthermore, high postoperative inpatient use was associated with an increased risk of persistent opio…
Restarting Essential Surgery in the Era of COVID-19 Open
On March 11, 2020 the World Health Organization declared the coronavirus (COVID-19) outbreak a global pandemic.1 In efforts to increase bed capacity, conserve vital medical resources, safeguard our patients, and protect frontline healthcar…
Treatment patterns and outcomes in goblet cell carcinoid tumors of the appendix Open
Background Goblet cell carcinoid (GCC) tumors of the appendix are a rare malignancy. We aim to examine the overall survival per stage and the relationship between different treatment modalities and outcomes for patients with GCC tumors of …
Systemic chemotherapy and survival in patients with metastatic low‐grade appendiceal mucinous adenocarcinoma Open
Background Appendiceal cancer is a rare malignancy that exhibits a wide range of histology and treatment response. Given the rarity and heterogeneous nature of the disease, it has been difficult to define optimal treatment strategies. Our …
Colorectal Cancer in Ukraine: Regional Disparities and National Trends in Incidence, Management, and Mortality Open
Purpose The incidence of colorectal cancer (CRC) is increasing worldwide, and the greatest increase is in low- to middle-income countries, such as Ukraine. Better knowledge of epidemiology of CRC in Ukraine is needed to understand how best…
Effect of an equal‐access military health system on racial disparities in colorectal cancer screening Open
BACKGROUND Racial disparities in colorectal cancer (CRC) screening are frequently attributed to variations in insurance status. The objective of this study was to ascertain whether universal insurance would lead to more equitable utilizati…
The homeobox protein VentX reverts immune suppression in the tumor microenvironment Open
Immune suppression in the tumor microenvironment (TME) is a central obstacle to effective immunotherapy. Tumor-associated macrophages (TAMs) are key components of the TME. Although TAMs have been viewed as an ideal target of intervention t…
Truth in Reporting: How Data Capture Methods Obfuscate Actual Surgical Site Infection Rates within a Health Care Network System Open
BACKGROUND: Two systems measure surgical site infection rates following colorectal surgeries: the American College of Surgeons National Surgical Quality Improvement Program and the Centers for Disease Control and Prevention National Health…
Implementation of a Comprehensive Post-Discharge Venous Thromboembolism Prophylaxis Program for Abdominal and Pelvic Surgery Patients Open
A systematic post-discharge VTE prophylaxis program including provider education, local guideline adaptation, bedside medication delivery, and education for at-risk patients, was associated with significantly fewer post-discharge VTE event…