Ronald C. Bruntz
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View article: Small Extracellular Vesicles From Radioresistant H3K27M‐Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response
Small Extracellular Vesicles From Radioresistant H3K27M‐Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response Open
Pediatric diffuse midline gliomas with the Histone 3 lysine 27‐to‐methionine mutation (H3K27M‐pDMG) are aggressive brain tumors characterized by intrinsic resistance to radiation therapy, the current standard of care. These tumors exhibit …
View article: Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis
Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis Open
Collagen glucosyltransferases catalyze collagen glucosylation critical for biology and diseases, yet their structural regulation remains unclear. Here, we report crystal structures of a mimiviral collagen glucosyltransferase in its apo for…
View article: Small Extracellular Vesicles from Radioresistant H3K27M-Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response
Small Extracellular Vesicles from Radioresistant H3K27M-Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response Open
Pediatric diffuse midline gliomas with the Histone 3 lysine 27-to-methionine mutation (H3K27M-pDMG) are aggressive brain tumors characterized by intrinsic resistance to radiation therapy, the current standard of care. These tumors exhibit …
View article: Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis
Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis Open
View article: Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model
Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model Open
View article: Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis
Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis Open
Matrix assisted laser desorption/ionization imaging has greatly improved our understanding of spatial biology, however a robust bioinformatic pipeline for data analysis is lacking. Here, we demonstrate the application of high-dimensionalit…
View article: In situ microwave fixation provides an instantaneous snapshot of the brain metabolome
In situ microwave fixation provides an instantaneous snapshot of the brain metabolome Open
Brain glucose metabolism is highly heterogeneous among brain regions and continues postmortem. In particular, we demonstrate exhaustion of glycogen and glucose and an increase in lactate production during conventional rapid brain resection…
View article: <i>In Situ</i> Microwave Fixation to Define the Terminal Rodent Brain Metabolome
<i>In Situ</i> Microwave Fixation to Define the Terminal Rodent Brain Metabolome Open
The brain metabolome directly connects to brain physiology and neuronal function. Brain glucose metabolism is highly heterogeneous among brain regions and continues postmortem. Therefore, challenges remain to capture an accurate snapshot o…
View article: Lactate supports a metabolic-epigenetic link in macrophage polarization
Lactate supports a metabolic-epigenetic link in macrophage polarization Open
Macrophages use mitochondrial lactate metabolism for ACLY-dependent histone acetylation, immune suppression, and tumor progression.
View article: Brain glycogen serves as a critical glucosamine cache required for protein glycosylation
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation Open
View article: APOE alters glucose flux through central carbon pathways in astrocytes
APOE alters glucose flux through central carbon pathways in astrocytes Open
View article: Author Index
Author Index Open
View article: De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues
De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues Open
Nucleotide synthesis is essential to proliferating cells, but the preferred precursors for de novo biosynthesis are not defined in human cancer tissues. We have employed multiplexed stable isotope-resolved metabolomics to track the …
View article: Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer
Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer Open
Large clinical trials and model systems studies suggest that the chemical form of selenium dictates chemopreventive and chemotherapeutic efficacy. Selenite induces excess ROS production, which mediates autophagy and eventual cell death in …
View article: Correction: Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS
Correction: Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS Open
Correction for ‘Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS’ by Pan Deng, et al., Analyst, 2018, 143, 311–322.
View article: Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS
Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS Open
The investigators report a dramatically improved chemoselective analysis for carbonyls in crude biological extracts by turning to a catalyst and freezing conditions for derivatization.
View article: Author Index
Author Index Open
View article: Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM)
Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM) Open
Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that us…