Ronald E. Engle
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View article: Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Genes associated with the twenty top-scored pathways of malignant hepatocytes of HDV-HCC.
View article: Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (n…
View article: Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with genes identified in malignant hepatocytes derived from HDV-, HBV- and HCV-HCC.
View article: Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Experimental design.
View article: Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Genes associated with the twenty top-scored pathways of malignant hepatocytes of HDV-HCC.
View article: Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
HBV DNA levels in tumorous and non-tumorous tissues of individual patients with HBV-associated HCC.
View article: Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with WLT-unique genes identified in the three tumors.
View article: Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Clusters of the 37 genes involved in the cell cycle and differentially expressed in malignant hepatocytes derived from HDV-HCC.
View article: Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
HBV DNA levels in tumorous and non-tumorous tissues of individual patients with HBV-associated HCC.
View article: Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Clusters of the 37 genes involved in the cell cycle and differentially expressed in malignant hepatocytes derived from HDV-HCC.
View article: Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Venn diagrams of differentially expressed genes obtained from laser capture microdissected hepatocytes and whole liver tissue of patients with HDV-, HBV-and HCV-associated HCC
View article: Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Venn diagrams of differentially expressed genes obtained from laser capture microdissected hepatocytes and whole liver tissue of patients with HDV-, HBV-and HCV-associated HCC
View article: Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with WLT-unique genes identified in the three tumors.
View article: Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Experimental design.
View article: Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with genes identified in malignant hepatocytes derived from HDV-, HBV- and HCV-HCC.
View article: Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (n…
View article: Incidence of Hepatitis E Infection in American Patients With Suspected Drug-Induced Liver Injury Is Low and Declining: The DILIN Prospective Study
Incidence of Hepatitis E Infection in American Patients With Suspected Drug-Induced Liver Injury Is Low and Declining: The DILIN Prospective Study Open
INTRODUCTION: Hepatitis E virus (HEV) infection rarely causes icteric hepatitis, yet 10%–40% of adult Americans have serological evidence of previous infection. The aim of this study was to investigate the incidence, presentation, and outc…
View article: Molecular Signature and Immune Landscape of HCV-Associated Hepatocellular Carcinoma (HCC): Differences and Similarities with HBV-HCC
Molecular Signature and Immune Landscape of HCV-Associated Hepatocellular Carcinoma (HCC): Differences and Similarities with HBV-HCC Open
This study demonstrates a distinctive molecular signature and immune landscape in HCC of different viral etiology, which could provide new insights into pathogenesis and lead to the development of novel immune-based therapies.
View article: Chitinase 3-like 1 is a profibrogenic factor overexpressed in the aging liver and in patients with liver cirrhosis
Chitinase 3-like 1 is a profibrogenic factor overexpressed in the aging liver and in patients with liver cirrhosis Open
Significance Older age at the time of hepatitis virus infection and age of liver donors are major determinants of liver fibrosis progression and disease severity. Our study demonstrates that aging is accompanied by significant changes in g…
View article: Distinct Cytokine Profiles Correlate with Disease Severity and Outcome in Longitudinal Studies of Acute Hepatitis B Virus and Hepatitis D Virus Infection in Chimpanzees
Distinct Cytokine Profiles Correlate with Disease Severity and Outcome in Longitudinal Studies of Acute Hepatitis B Virus and Hepatitis D Virus Infection in Chimpanzees Open
Studies performed in chimpanzees at the National Institutes of Health (NIH) demonstrated a significant difference in ALT levels during acute hepatitis of different viral etiologies, with a hierarchy in the extent of liver damage according …
View article: Role of Hepatitis E Virus Infection in North American Patients With Severe Acute Liver Injury
Role of Hepatitis E Virus Infection in North American Patients With Severe Acute Liver Injury Open
INTRODUCTION: The aim of this study was to determine the role of hepatitis E virus (HEV) infection in a large cohort of prospectively enrolled patients with severe acute liver injury (ALI). METHODS: Serum samples from 594 consecutive adult…
View article: Distinct disease features in chimpanzees infected with a precore HBV mutant associated with acute liver failure in humans
Distinct disease features in chimpanzees infected with a precore HBV mutant associated with acute liver failure in humans Open
Transmission to chimpanzees of a precore hepatitis B virus (HBV) mutant implicated in acute liver failure (ALF) in humans did not cause ALF nor the classic form of acute hepatitis B (AHB) seen upon infection with the wild-type HBV strain, …
View article: Next‐generation sequencing of the intrahepatic antibody repertoire delineates a unique B‐cell response in HBV‐associated acute liver failure
Next‐generation sequencing of the intrahepatic antibody repertoire delineates a unique B‐cell response in HBV‐associated acute liver failure Open
Hepatitis B virus (HBV) is a major cause of acute liver failure (ALF) worldwide. While liver damage in classic acute hepatitis B is believed to be T‐cell mediated, the pathogenesis of HBV‐associated ALF remains largely unknown. Access to l…
View article: Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (n = …
View article: Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma
Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma Open
Entry of hepatitis C virus (HCV) into hepatocytes is a complex process that involves numerous cellular factors, including the scavenger receptor class B type 1 (SR-B1), the tetraspanin CD81, and the tight junction (TJ) proteins claudin-1 (…
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The report of Renou et al. adds to our growing understanding of the complex epidemiology of hepatitis E virus (HEV) infection among individuals residing in industrialized countries. HEV is a single-stranded RNA virus that can be spread thr…
View article: The role of hepatitis E virus infection in adult Americans with acute liver failure
The role of hepatitis E virus infection in adult Americans with acute liver failure Open
Acute hepatitis E virus (HEV) infection is a leading cause of acute liver failure (ALF) in many developing countries, yet rarely identified in Western countries. Given that antibody testing for HEV infection is not routinely obtained, we h…
View article: Diminished viral replication and compartmentalization of hepatitis C virus in hepatocellular carcinoma tissue
Diminished viral replication and compartmentalization of hepatitis C virus in hepatocellular carcinoma tissue Open
Significance Hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) infection is the fastest-rising cause of cancer-related death in the United States. The level of intratumor HCV replication and the molecular interactions …
View article: The Association of Cytokines and Micronutrients with Hepatitis E Virus Infection During Pregnancy and the Postpartum Period in Rural Bangladesh
The Association of Cytokines and Micronutrients with Hepatitis E Virus Infection During Pregnancy and the Postpartum Period in Rural Bangladesh Open
Hepatitis E virus (HEV) infection is severe during pregnancy, with a pregnant case fatality rate around 30%. In Bangladesh, plasma samples from 1,100 women during the first trimester (TM) and third TM of pregnancy and 3 months postpartum (…
View article: An Epidemiologic Investigation of a Case of Acute Hepatitis E
An Epidemiologic Investigation of a Case of Acute Hepatitis E Open
Hepatitis E virus (HEV) is considered a zoonotic infection in developed nations. A case of acute hepatitis E in a researcher following a scalpel injury while working on a pig prompted a seroepidemiologic study to identify potential modes o…