Ronald M. Galiwango
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View article: Real-time PCR assay design and validation for Prevotella bivia, Peptostreptococcus anaerobius, and Dialister micraerophilus, bacteria associated with increased HIV susceptibility
Real-time PCR assay design and validation for Prevotella bivia, Peptostreptococcus anaerobius, and Dialister micraerophilus, bacteria associated with increased HIV susceptibility Open
View article: Diagnostic and analytic performance of four point-of-care hemoglobin testing devices used in routine HIV and maternity care in Uganda
Diagnostic and analytic performance of four point-of-care hemoglobin testing devices used in routine HIV and maternity care in Uganda Open
All devices demonstrated clinically acceptable performance (within ± 1 g/dL of the reference hemoglobin), with the HemoCue Hb 301, DiaSpect Tm and Hemo Control performing most comparable to the standard, suggesting potential for interchang…
View article: Patterns of HIV-1 viral load suppression and drug resistance during the dolutegravir transition: a population-based longitudinal study
Patterns of HIV-1 viral load suppression and drug resistance during the dolutegravir transition: a population-based longitudinal study Open
Background Data on the population-scale impact of dolutegravir (DTG)-based HIV regimens in sub-Saharan Africa are extremely limited. We used data from a surveillance cohort in southern Uganda to assess viral suppression and antiretroviral …
View article: Longitudinal patterns of penile <scp>human papillomavirus</scp> detection among Ugandan men: A prospective sampling study
Longitudinal patterns of penile <span>human papillomavirus</span> detection among Ugandan men: A prospective sampling study Open
Human papillomavirus (HPV) is a highly prevalent sexually transmitted infection, yet data on HPV dynamics in African male populations remain limited. We conducted a prospective study of 300 human immunodeficiency virus‐negative, sexually a…
View article: Clade I mpox vaccination: strategies for deployment and evaluation
Clade I mpox vaccination: strategies for deployment and evaluation Open
View article: HIV-phyloTSI: subtype-independent estimation of time since HIV-1 infection for cross-sectional measures of population incidence using deep sequence data
HIV-phyloTSI: subtype-independent estimation of time since HIV-1 infection for cross-sectional measures of population incidence using deep sequence data Open
View article: HIV cure research contributions from Africa in the last three decades
HIV cure research contributions from Africa in the last three decades Open
Introduction The HIV epidemic in Africa is characterized by extensive viral subtype diversity and human genetic heterogeneity which influence disease outcomes; amidst the co-morbidities that modulate HIV reservoirs and immune responses. Th…
View article: Severe Acute Respiratory Syndrome Coronavirus-2 antigen and Immunoglobulin G positivity among residents of South-Central Uganda: September 2021 – August 2022
Severe Acute Respiratory Syndrome Coronavirus-2 antigen and Immunoglobulin G positivity among residents of South-Central Uganda: September 2021 – August 2022 Open
View article: Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage
Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage Open
Introduction To prioritize and tailor interventions for ending AIDS by 2030 in Africa, it is important to characterize the population groups in which human immunodeficiency virus (HIV) viraemia is concentrating. Methods We analysed HIV tes…
View article: An Enhanced Retention Strategy to Prevent the Vertical Transmission of HIV in Uganda: A Budget Impact Analysis
An Enhanced Retention Strategy to Prevent the Vertical Transmission of HIV in Uganda: A Budget Impact Analysis Open
Implementing the ERS would significantly increase the Ugandan Ministry of Health's budget, but most additional costs would be accrued from the resulting expansion of ART client volume. The ERS is a relatively low-cost intervention to reduc…
View article: Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes
Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes Open
Human Immunodeficiency Virus type 1 (HIV-1) is responsible for the global HIV/AIDS epidemic and the establishment of an integrated HIV-1 reservoir remains the primary obstacle to cure. Upon therapy interruption, reactivation of the persist…
View article: Quantifying prevalence and risk factors of HIV multiple infection in Uganda from population-based deep-sequence data
Quantifying prevalence and risk factors of HIV multiple infection in Uganda from population-based deep-sequence data Open
People living with HIV can acquire secondary infections through a process called superinfection, giving rise to simultaneous infection with genetically distinct variants (multiple infection). Multiple infection provides the necessary condi…
View article: HIV-associated penile anaerobes disrupt epithelial barrier integrity
HIV-associated penile anaerobes disrupt epithelial barrier integrity Open
Specific anaerobic taxa within the penile microbiome—the Bacteria Associated with Seroconversion, Inflammation and Immune Cells (BASIC) species—enhance HIV-1 susceptibility, in part by recruiting susceptible cells to the inner foreskin. Ho…
View article: HIV seroprevalence, incidence, and viral suppression among Ugandan males with bar or sex worker partners: a population-based study
HIV seroprevalence, incidence, and viral suppression among Ugandan males with bar or sex worker partners: a population-based study Open
Background Female bar or sex workers (FBSWs) in Eastern Africa experience a high burden of HIV. However, there is limited population-level data on HIV seroprevalence, incidence, and viral suppression among their male partners. Methods Men …
View article: HIV seroprevalence, incidence, and viral suppression among Ugandan female bar workers: a population-based study
HIV seroprevalence, incidence, and viral suppression among Ugandan female bar workers: a population-based study Open
Background Prior studies have linked female bar and sex work in Africa. However, population-level data on HIV burden among female bar workers (FBWs) in African settings are rare. Methods We used five survey rounds of data collected between…
View article: Association between HIV-1 Nef-mediated MHC-I downregulation and the maintenance of the replication-competent latent viral reservoir in individuals with virally suppressed HIV-1 in Uganda: an exploratory cohort study
Association between HIV-1 Nef-mediated MHC-I downregulation and the maintenance of the replication-competent latent viral reservoir in individuals with virally suppressed HIV-1 in Uganda: an exploratory cohort study Open
Canadian Institutes of Health Research, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, and the REACH Martin Delaney Collaboratory.
View article: Autoantibodies to interferon alpha, nuclear antigens, cardiolipin, and beta 2 glycoprotein 1 in a Ugandan cohort and their relation to SARS-CoV-2 infection
Autoantibodies to interferon alpha, nuclear antigens, cardiolipin, and beta 2 glycoprotein 1 in a Ugandan cohort and their relation to SARS-CoV-2 infection Open
Our findings contribute to the limited literature on AAb prevalence in East Africa and suggest that SARS-CoV-2 does not induce these AAbs.
View article: Longitudinal seroprevalence of Crimean-Congo hemorrhagic fever virus in Southern Uganda
Longitudinal seroprevalence of Crimean-Congo hemorrhagic fever virus in Southern Uganda Open
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease endemic to many regions of Africa, the Middle East, Southeast Asia and the Balkans. Caused by the CCHF virus (CCHFV), CCHF has been a recognized cause of illness in Uganda sinc…
View article: Gardnerella vaginalis-binding IgA in the urethra of sexually experienced males
Gardnerella vaginalis-binding IgA in the urethra of sexually experienced males Open
View article: Evaluating the biomedical and behavioural drivers of HIV-1 incidence decline in adolescent girls and young women in Uganda: A mathematical modelling study
Evaluating the biomedical and behavioural drivers of HIV-1 incidence decline in adolescent girls and young women in Uganda: A mathematical modelling study Open
Background: Recent declines in HIV incidence among adolescent girls and young women (AGYW) in Africa are often attributed to the expansion of biomedical interventions such as antiretroviral therapy and voluntary medical male circumcision. …
View article: HIV Seroprevalence, Incidence, and Viral Suppression Among Ugandan Female Bar Workers: A Population-Based Study
HIV Seroprevalence, Incidence, and Viral Suppression Among Ugandan Female Bar Workers: A Population-Based Study Open
View article: The potential promise and pitfalls of point-of-care viral load monitoring to expedite HIV treatment decision-making in rural Uganda: a qualitative study
The potential promise and pitfalls of point-of-care viral load monitoring to expedite HIV treatment decision-making in rural Uganda: a qualitative study Open
View article: Quantifying prevalence and risk factors of HIV multiple infection in Uganda from population-based deep-sequence data
Quantifying prevalence and risk factors of HIV multiple infection in Uganda from population-based deep-sequence data Open
People living with HIV can be simultaneously infected with genetically distinct variants. This can occur either at the time of initial infection (“coinfection”) or at a later time-point (“superinfection”). Multiple infection provides the n…
View article: Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial
Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial Open
View article: HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy
HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy Open
View article: Household transport ownership and HIV viral suppression in rural Uganda: a cross- sectional, population-based study
Household transport ownership and HIV viral suppression in rural Uganda: a cross- sectional, population-based study Open
Background Empirical data on transportation access and HIV treatment outcomes in sub-Saharan Africa are rare. We assessed the association between household transport ownership and HIV viral suppression in rural Uganda. Methods The study wa…
View article: Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage
Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage Open
Introduction To prioritize and tailor interventions for ending AIDS by 2030 in Africa, it is important to characterize the population groups in which HIV viraemia is concentrating. Methods We analysed HIV testing and viral load data collec…
View article: Increasing intra- and inter-subtype HIV diversity despite declining HIV incidence in Uganda
Increasing intra- and inter-subtype HIV diversity despite declining HIV incidence in Uganda Open
HIV incidence has been declining in Africa with scale-up of HIV interventions. However, there is limited data on HIV evolutionary trends in African populations with waning epidemics. We evaluated changes in HIV viral diversity and genetic …
View article: Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen
Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen Open
View article: Effective and targeted latency reversal in CD4 <sup>+</sup> T cells from individuals on long term combined antiretroviral therapy initiated during chronic HIV-1 infection
Effective and targeted latency reversal in CD4 <sup>+</sup> T cells from individuals on long term combined antiretroviral therapy initiated during chronic HIV-1 infection Open
To date, an affordable, effective treatment for an HIV-1 cure remains only a concept with most "latency reversal" agents (LRAs) lacking specificity for the latent HIV-1 reservoir and failing in early clinical trials. We assessed HIV-1 late…