Ronald Jackups
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View article: Prediction of transmembrane beta-barrel structures.
Prediction of transmembrane beta-barrel structures. Open
Prediction of transmembrane beta-barrel structures.
View article: Proceedings of the Association for Pathology Informatics Bootcamp 2023: Ethics, equity, and regulations
Proceedings of the Association for Pathology Informatics Bootcamp 2023: Ethics, equity, and regulations Open
The Pathology Informatics Bootcamp is held annually at the Pathology Informatics Summit and provides pathology trainees with knowledge about both core and emerging topics in the rapidly evolving field of Pathology Informatics. In 2023, the…
View article: Racial Equity in Urine Drug Screening Policies in Labor and Delivery
Racial Equity in Urine Drug Screening Policies in Labor and Delivery Open
Importance Black pregnant patients are significantly more likely than their White counterparts to undergo peripartum urine drug screening (UDS) and subsequent reporting to child protective services (CPS). Objective To evaluate the associat…
View article: Evaluating Use of Generative Artificial Intelligence in Clinical Pathology Practice: Opportunities and the Way Forward
Evaluating Use of Generative Artificial Intelligence in Clinical Pathology Practice: Opportunities and the Way Forward Open
Context.— Generative artificial intelligence (GAI) technologies are likely to dramatically impact health care workflows in clinical pathology (CP). Applications in CP include education, data mining, decision support, result summaries, and …
View article: Harnessing the Power of Generative Artificial Intelligence in Pathology Education: Opportunities, Challenges, and Future Directions
Harnessing the Power of Generative Artificial Intelligence in Pathology Education: Opportunities, Challenges, and Future Directions Open
Context.— Generative artificial intelligence (AI) technologies are rapidly transforming numerous fields, including pathology, and hold significant potential to revolutionize educational approaches. Objective.— To explore the application of…
View article: Challenges in reliable preoperative blood ordering: A qualitative interview study
Challenges in reliable preoperative blood ordering: A qualitative interview study Open
Background Presurgical blood orders are important for patient safety during surgery, but excess orders can be costly to patients and the healthcare system. We aimed to assess clinician perceptions on the presurgical blood ordering process …
View article: Acute pulmonary injury in hematology patients supported with pathogen-reduced and conventional platelet components
Acute pulmonary injury in hematology patients supported with pathogen-reduced and conventional platelet components Open
Patients treated with antineoplastic therapy often develop thrombocytopenia requiring platelet transfusion, which has potential to exacerbate pulmonary injury. This study tested the hypothesis that amotosalen-UVA pathogen–reduced platelet …
View article: Automating the Detection of IV Fluid Contamination Using Unsupervised Machine Learning
Automating the Detection of IV Fluid Contamination Using Unsupervised Machine Learning Open
Background Intravenous (IV) fluid contamination is a common cause of preanalytical error that can delay or misguide treatment decisions, leading to patient harm. Current approaches for detecting contamination rely on delta checks, which re…
View article: The Million Patient Labset: A large, de-identified dataset of longitudinal clinical laboratory results from one million patients
The Million Patient Labset: A large, de-identified dataset of longitudinal clinical laboratory results from one million patients Open
Laboratory testing is integral to the diagnosis and treatment of disease. Advances in electronic medical records and computation have initiated an era of ‘big data’ for laboratory medicine. However, most health data continues to exist in i…
View article: Analysis of daratumumab reporting in type and screen orders to identify opportunities for information system improvement
Analysis of daratumumab reporting in type and screen orders to identify opportunities for information system improvement Open
The rapid growth of monoclonal antibody therapies has resulted in a wide variety of targeted treatments towards malignancies. The presence of these antibodies in patient plasma can interfere with blood bank testing, which in turn can creat…
View article: Anticoagulation management in patients tested for heparin-induced thrombocytopenia in the cardiothoracic intensive care unit diverges from expert guidelines
Anticoagulation management in patients tested for heparin-induced thrombocytopenia in the cardiothoracic intensive care unit diverges from expert guidelines Open
Heparin-induced thrombocytopenia (HIT) is a rare, life-threatening complication in patients receiving heparin products. Clinical scoring tools, such as the ‘4T’ score, aim to help identify patients at risk for HIT and are recommended by ex…
View article: Machine learning pipelines developed for the prediction of cancelation of inappropriate parathyroid hormone-related peptide orders demonstrate poor performance in predicting provider behavior
Machine learning pipelines developed for the prediction of cancelation of inappropriate parathyroid hormone-related peptide orders demonstrate poor performance in predicting provider behavior Open
Background: Quantification of circulating parathyroid hormone-related peptide (PTHrP) aids in the diagnosis of humoral hypercalcemia of malignancy. However, utilization of this test in the setting of low pre-test probability leads to false…
View article: A Single Reference Interval for Interpreting Serum Free Light Chains across Patients with Varying Renal Function
A Single Reference Interval for Interpreting Serum Free Light Chains across Patients with Varying Renal Function Open
Background Serum free light chain (sFLC) assays are interpreted using a sFLC-ratio-based reference interval (manufacturer’s interval) that was defined using a cohort of healthy patients. However, renal impairment elevates the sFLC-ratio, l…
View article: The next phase in patient safety education: Towards a standardized, tools-based pathology patient safety curriculum
The next phase in patient safety education: Towards a standardized, tools-based pathology patient safety curriculum Open
Patient safety education is a mandated Common Program Requirement of the Accreditation Council for Graduate Medical Education and for the Royal College of Physicians and Surgeons of Canada in all medical residency and fellowship programs. …
View article: FDA Regulation of Laboratory Clinical Decision Support Software: Is It a Medical Device?
FDA Regulation of Laboratory Clinical Decision Support Software: Is It a Medical Device? Open
Journal Article FDA Regulation of Laboratory Clinical Decision Support Software: Is It a Medical Device? Get access Ronald Jackups, Jr. Ronald Jackups, Jr. Associate Professor, Department of Pathology and Immunology, Washington University …
View article: “Customers Like You Also Ordered …”
“Customers Like You Also Ordered …” Open
Inappropriate laboratory test utilization is a significant challenge for clinical laboratories attempting to improve patient care while minimizing waste of resources.1 Overordering of tests is a high-priority target for laboratories due to…
View article: Organizational preparedness for the use of large language models in pathology informatics
Organizational preparedness for the use of large language models in pathology informatics Open
In this paper, we consider the current and potential role of the latest generation of Large Language Models (LLMs) in medical informatics, particularly within the realms of clinical and anatomic pathology. We aim to provide a thorough unde…
View article: Comparative risk of pulmonary adverse events with transfusion of pathogen reduced and conventional platelet components
Comparative risk of pulmonary adverse events with transfusion of pathogen reduced and conventional platelet components Open
Background Platelet transfusion carries risk of transfusion‐transmitted infection (TTI). Pathogen reduction of platelet components (PRPC) is designed to reduce TTI. Pulmonary adverse events (AEs), including transfusion‐related acute lung i…
View article: Clinical Decision Support for Laboratory Testing
Clinical Decision Support for Laboratory Testing Open
Background As technology enables new and increasingly complex laboratory tests, test utilization presents a growing challenge for healthcare systems. Clinical decision support (CDS) refers to digital tools that present providers with clini…
View article: In Reply: COVID-19: An Argument for Rapid Access to Laboratory Data Warehouses
In Reply: COVID-19: An Argument for Rapid Access to Laboratory Data Warehouses Open
hypotheses, which can be validated in further research.Hughey and Colby showed a good example of an experimental validation of their statistical analysis (1).To reduce false conclusions from data analysis, we have experienced that close co…
View article: Impact of an electronic hard-stop clinical decision support tool to limit repeat <i>Clostridioides difficile</i> toxin enzyme immunoassay testing on test utilization
Impact of an electronic hard-stop clinical decision support tool to limit repeat <i>Clostridioides difficile</i> toxin enzyme immunoassay testing on test utilization Open
We performed an intervention evaluating the impact of an electronic hard-stop clinical decision support tool on repeat Clostridioides difficile (CD) toxin enzyme immunoassay (T-EIA) testing. The CD testing rate and number of admissions wit…
View article: Answering Unanswerable Questions in the Clinical Laboratory with Data Warehouses
Answering Unanswerable Questions in the Clinical Laboratory with Data Warehouses Open
Laboratorians face many “unanswerable” questions in their daily work. What caused a false-positive test in this patient, when all the known interferences have been ruled out? How can I identify mislabeled specimens in the laboratory, when …
View article: Incidence and Diagnostic Yield of Repeat Urine Culture in Hospitalized Patients: an Opportunity for Diagnostic Stewardship
Incidence and Diagnostic Yield of Repeat Urine Culture in Hospitalized Patients: an Opportunity for Diagnostic Stewardship Open
There is limited knowledge on the incidence, diagnostic yield, and cost associated with inappropriate repeat urine cultures. The factors that affect repeat urine culturing practices are not well understood. We conducted a retrospective stu…