Ronald L. Neppl
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View article: Loss of HNRNPU in Skeletal Muscle Increases Intramuscular Infiltration of Ly6C Positive Cells, leading to Muscle Atrophy through Activation of NF‐κB Signaling
Loss of HNRNPU in Skeletal Muscle Increases Intramuscular Infiltration of Ly6C Positive Cells, leading to Muscle Atrophy through Activation of NF‐κB Signaling Open
Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is known to play multiple biological roles by regulating transcriptional expression, RNA splicing, RNA stability, and chromatin structure in a tissue‐dependent manner. The role of hnRNPU i…
View article: VEGFA Promotes Skeletal Muscle Regeneration in Aging
VEGFA Promotes Skeletal Muscle Regeneration in Aging Open
Aging is associated with loss of skeletal muscle regeneration. Differentially regulated vascular endothelial growth factor (VEGF)A with aging may partially underlies this loss of regenerative capacity. To assess the role of VEGFA in muscle…
View article: Downregulation of VEGFA Impairs Post-traumatic Senile Muscle Regeneration
Downregulation of VEGFA Impairs Post-traumatic Senile Muscle Regeneration Open
Purpose: The population representing trauma in adults aged >65 years alone are projected to increase financial burden on the healthcare system by nearly $375billion. Aging is associated with frailty, a parameter that correlates significant…
View article: AGING-RELATED VEGF IMPAIRS MUSCLE REGENERATION
AGING-RELATED VEGF IMPAIRS MUSCLE REGENERATION Open
Purpose Aging is associated with frailty, a parameter that correlates with mortality and loss of muscle mass. The molecular mechanisms behind aging-associated impairment of muscle regeneration remain incompletely understood. We hypothesize…
View article: 99. Aging Associated Loss of Vegfa Impairs Muscle Regeneration
99. Aging Associated Loss of Vegfa Impairs Muscle Regeneration Open
Purpose: Global populations, particularly in developed countries, have continued to age. Notably, aging is intimately correlated with frailty, a parameter that has been previously demonstrated to correlate significantly with mortality and …
View article: Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links
Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links Open
Skeletal muscle atrophy in an inevitable occurrence with advancing age, and a consequence of disease including cancer. Muscle atrophy in the elderly is managed by a regimen of resistance exercise and increased protein intake. Understanding…
View article: Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle
Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle Open
In vivo protein kinases A and G (PKA and PKG) coordinately phosphorylate a broad range of substrates to mediate their various physiological effects. The functions of many of these substrates have yet to be defined genetically. Herein we sh…
View article: The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly
The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly Open
Set7 associates with the MyoD transcription factor to enhance expression of genes required for muscle differentiation.The molecular events that modulate chromatin structure during skeletal muscle differentiation are still poorly understood…
View article: Loss of ARNT in skeletal muscle limits muscle regeneration in aging
Loss of ARNT in skeletal muscle limits muscle regeneration in aging Open
The ability of skeletal muscle to regenerate declines significantly with aging. The expression of aryl hydrocarbon receptor nuclear translocator (ARNT), a critical component of the hypoxia signaling pathway, was less abundant in skeletal m…
View article: RNA binding protein hnRNP-U is required for physiological hypertrophy of skeletal muscle
RNA binding protein hnRNP-U is required for physiological hypertrophy of skeletal muscle Open
Skeletal muscle has the remarkable ability to modulate its mass in response to physiological changes associated with nutritional input, functional utilization, systemic disease, and age. A decreased responsiveness to anabolic stimuli is th…
View article: IMPACT OF FRAILTY ON OUTCOMES IN SURGICAL PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
IMPACT OF FRAILTY ON OUTCOMES IN SURGICAL PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS Open
BACKGROUND: The concept of frailty was introduced to explain the discrepancies that exist between patients’ chronological and physiological age. The efficacy of the modified frailty index (mFI) to predict surgical risk is not clear. We sou…
View article: lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy
lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy Open
Skeletal muscle exhibits remarkable plasticity in its ability to modulate its mass in response to the physiologic changes associated with functional use, systemic disease, and aging. Although a gradual loss of muscle mass normally occurs w…