Ronald Zolty
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View article: Comparative effects of glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors on heart failure with preserved ejection fraction in diabetic patients: a meta-analysis
Comparative effects of glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors on heart failure with preserved ejection fraction in diabetic patients: a meta-analysis Open
View article: Exploring the Influence of Contextual Factors and the Caregiving Process on Caregiver Burden and Quality of Life Outcomes of Heart Failure (HF) Dyads after a Hospital Discharge: A Mixed-Methods Study
Exploring the Influence of Contextual Factors and the Caregiving Process on Caregiver Burden and Quality of Life Outcomes of Heart Failure (HF) Dyads after a Hospital Discharge: A Mixed-Methods Study Open
Background: This study explores heart failure (HF) dyadic contextual factors and caregiver burden during acute exacerbation hospitalization and discharge. Methods: It employed a mixed-methods approach, with HF dyads completing questionnair…
View article: Parenteral treprostinil induction for rapid attainment of therapeutic doses of oral treprostinil
Parenteral treprostinil induction for rapid attainment of therapeutic doses of oral treprostinil Open
Short-course parenteral treprostinil induction resulted in oral treprostinil doses over twice those reported in de novo initiations and may be a useful approach to quickly achieve the therapeutic benefits of oral treprostinil.
View article: Table of Contents
Table of Contents Open
View article: 1,1-Difluoroethane Hydrocarbon Cardiomyopathy
1,1-Difluoroethane Hydrocarbon Cardiomyopathy Open
View article: The Role of Neurohormonal Systems, Inflammatory Mediators and Oxydative Stress in Cardiomyopathy
The Role of Neurohormonal Systems, Inflammatory Mediators and Oxydative Stress in Cardiomyopathy Open
Cardiomyopathy and more specifically the dilated cardiomyopathy, regardless of severity, is associated with activation of neuro-hormonal, cytokine and oxidative stress signaling pathways that alter the structure and function of cardiac myo…
View article: Pulmonary Function Testing Pre–heart Transplant Predicts Posttransplant Survival
Pulmonary Function Testing Pre–heart Transplant Predicts Posttransplant Survival Open
Introduction. Although pulmonary function testing (PFT) is typically performed for heart transplant evaluation, the prognostic utility of PFTs after transplantation is unknown. We evaluated whether PFT parameters were correlated with outco…
View article: Novel Experimental Therapies for Treatment of Pulmonary Arterial Hypertension
Novel Experimental Therapies for Treatment of Pulmonary Arterial Hypertension Open
Pulmonary arterial hypertension (PAH) is a progressive and devastating disease characterized by pulmonary artery vasoconstriction and vascular remodeling leading to vascular rarefaction with elevation of pulmonary arterial pressures and pu…
View article: Role of Selexipag in Chronic Obstructive Pulmonary Disease (COPD) Patients With Out-of-Proportion Pulmonary Hypertension
Role of Selexipag in Chronic Obstructive Pulmonary Disease (COPD) Patients With Out-of-Proportion Pulmonary Hypertension Open
Pulmonary hypertension (PH) in patients with chronic obstructive pulmonary disease (COPD) is associated with an increase in the risk of COPD exacerbation, increased hospitalization, and worse survival in this patient population. No specifi…
View article: Levosimendan Improves Hemodynamics and Exercise Tolerance in PH-HFpEF
Levosimendan Improves Hemodynamics and Exercise Tolerance in PH-HFpEF Open
Six weeks of once-weekly levosimendan infusion did not affect exercise-PCWP but did reduce PCWP incorporating data from rest and exercise, in tandem with increased 6MWD. Further study of levosimendan is warranted as a therapeutic option fo…
View article: Perioperative Management of Pheochromocytoma Resection in a Patient with a Continuous Flow Left Ventricular Assist Device
Perioperative Management of Pheochromocytoma Resection in a Patient with a Continuous Flow Left Ventricular Assist Device Open
Current generation LVADs provide continuous blood flow which has been shown to increase sympathetic tone. Pheochromocytoma is a rare neuroendocrine tumor which classically presents with episodic hypertension, palpitations and headaches. Ca…
View article: Methylene Blue to the Rescue in Accidental Treprostinil Overdose
Methylene Blue to the Rescue in Accidental Treprostinil Overdose Open
The incidence of pulmonary hypertension (PH) has been rising enormously over the past few years, with more systemic diseases being found to be associated with it. A better understanding of the pathophysiology of PH has led to the developme…
View article: Rates of and Risk Factors for CMV Reactivation Following LVAD Implantation
Rates of and Risk Factors for CMV Reactivation Following LVAD Implantation Open
IntroductionWhile cytomegalovirus (CMV) reactivation occurs frequently in immunocompetent patients who are critically ill and has been associated with worse outcomes, very few cases of CMV reactivation have been reported following left ven…
View article: Role of Selexipag in COPD Patients with out of Proportion Pulmonary Hypertension
Role of Selexipag in COPD Patients with out of Proportion Pulmonary Hypertension Open
View article: Electrocardiographic characteristics, antiarrhythmic utilization, and outcomes in patients with left ventricular assist devices
Electrocardiographic characteristics, antiarrhythmic utilization, and outcomes in patients with left ventricular assist devices Open
Background
Left ventricular assist devices (LVAD) are an increasingly used therapy for patients with advanced heart failure. Arrhythmias are common complications following LVAD implantation requiring admission, initiation, and escalation …
View article: Prior Median Sternotomy Results in Increased Mortality Following LVAD Implantation
Prior Median Sternotomy Results in Increased Mortality Following LVAD Implantation Open
View article: New heart failure pharmacotherapy in clinical trials: <i>a hope in progress</i>
New heart failure pharmacotherapy in clinical trials: <i>a hope in progress</i> Open
View article: Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction
Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction Open
Neuregulins are important growth factors involved in cardiac development and response to stress. Certain isoforms and fragments of neuregulin have been found to be cardioprotective. The effects of a full-length neuregulin-1β isoform, glial…
View article: A Phase I, Single Ascending Dose Study of Cimaglermin Alfa (Neuregulin 1β3) in Patients With Systolic Dysfunction and Heart Failure
A Phase I, Single Ascending Dose Study of Cimaglermin Alfa (Neuregulin 1β3) in Patients With Systolic Dysfunction and Heart Failure Open
A first-in-human, phase 1, double blind, placebo-controlled, single ascending dose study examined the safety, tolerability, and exploratory efficacy of intravenous infusion of a recombinant growth factor, cimaglermin alfa, in patients with…
View article: Targeted myocardial gene expression in failing hearts by RNA sequencing
Targeted myocardial gene expression in failing hearts by RNA sequencing Open
Heart failure is associated with a network of transcriptional changes involving contractile proteins, metabolism, adrenergic receptors, protein phosphorylation, and signaling factors. Myocardial MYLK and IL-6 expression are positively corr…
View article: Fever of Unknown Origin in Patient after Left Ventricular Assist Device Implantation
Fever of Unknown Origin in Patient after Left Ventricular Assist Device Implantation Open
Mechanical circulatory support (MCS) is a lifesaving procedure in patients with refractory cardiogenic shock. Despite improvement in surgical techniques, ICU care and restored hemodynamics, some patients on MCS remain severely debilitated …
View article: Fever of Unknown Origin in Patient after Left Ventricular Assist Device Implantation
Fever of Unknown Origin in Patient after Left Ventricular Assist Device Implantation Open
Mechanical circulatory support (MCS) is a lifesaving procedure in patients with refractory cardiogenic shock. Despite improvement in surgical techniques, ICU care and restored hemodynamics, some patients on MCS remain severely debilitated …
View article: Blood Pressure and Adverse Events During Continuous Flow Left Ventricular Assist Device Support
Blood Pressure and Adverse Events During Continuous Flow Left Ventricular Assist Device Support Open
Background— Adverse events (AEs), such as intracranial hemorrhage, thromboembolic event, and progressive aortic insufficiency, create substantial morbidity and mortality during continuous flow left ventricular assist device support yet the…
View article: Mortality and Readmission Rates in Patients Hospitalized for Acute Decompensated Heart Failure: A Comparison Between Cardiology and General‐Medicine Service Outcomes in an Underserved Population
Mortality and Readmission Rates in Patients Hospitalized for Acute Decompensated Heart Failure: A Comparison Between Cardiology and General‐Medicine Service Outcomes in an Underserved Population Open
Background With recent legislation imposing penalties on hospitals for above‐average 30‐day all‐cause readmissions for patients with acute decompensated heart failure ( ADHF ), there is concern these penalties will more heavily impact hosp…
View article: Therapeutic Molecular Phenotype of β-Blocker–Associated Reverse-Remodeling in Nonischemic Dilated Cardiomyopathy
Therapeutic Molecular Phenotype of β-Blocker–Associated Reverse-Remodeling in Nonischemic Dilated Cardiomyopathy Open
Background— When β-blockers produce reverse-remodeling in idiopathic dilated cardiomyopathy, they partially reverse changes in fetal–adult/contractile protein, natriuretic peptide, SR-Ca 2+ -ATPase gene program constituents. The objective …