Ronan Bellouard
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View article: N-acetylcysteine use in a cocaine-induced liver failure: a case report
N-acetylcysteine use in a cocaine-induced liver failure: a case report Open
Background Cocaine intoxication and abuse is a worldwide problem that can be the cause of numerous acute medical complications, including severe acute hepatitis. Although these cases are scarce, they are extremely serious and may lead to l…
View article: Development of a Predictive Dosing Nomogram to Achieve PK/PD Targets of Amikacin Initial Dose in Critically Ill Patients: A Non-Parametric Approach
Development of a Predictive Dosing Nomogram to Achieve PK/PD Targets of Amikacin Initial Dose in Critically Ill Patients: A Non-Parametric Approach Open
French guidelines recommend reaching an amikacin concentration of ≥8 × MIC 1 h after beginning infusion (C1h), with MIC = 8 mg/L for probabilistic therapy. We aimed to elaborate a nomogram guiding clinicians in choosing the right first ami…
View article: Response to “<scp>CYP450 3A4</scp>/5 Containment During <scp>SARS‐CoV</scp>‐2 Infection”
Response to “<span>CYP450 3A4</span>/5 Containment During <span>SARS‐CoV</span>‐2 Infection” Open
International audience
View article: Impact of Inflammation on Midazolam Metabolism in Severe COVID‐19 Patients
Impact of Inflammation on Midazolam Metabolism in Severe COVID‐19 Patients Open
Midazolam is a benzodiazepine frequently used for sedation in patients hospitalized in the intensive care unit (ICU) for coronavirus disease 2019 (COVID‐19). This drug is primarily metabolized by cytochrome P450 3A (CYP3A) isoenzymes. Seve…
View article: Evaluation of the safety and efficacy of XAV-19 in patients with COVID-19-induced moderate pneumonia: study protocol for a randomized, double-blinded, placebo-controlled phase 2 (2a and 2b) trial
Evaluation of the safety and efficacy of XAV-19 in patients with COVID-19-induced moderate pneumonia: study protocol for a randomized, double-blinded, placebo-controlled phase 2 (2a and 2b) trial Open
View article: A murine model to study the gut bacteria parameters during complex antibiotics like cefotaxime and ceftriaxone treatment
A murine model to study the gut bacteria parameters during complex antibiotics like cefotaxime and ceftriaxone treatment Open
View article: Lopinavir pharmacokinetics in COVID-19 patients
Lopinavir pharmacokinetics in COVID-19 patients Open
International audience
View article: Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis
Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis Open
View article: Simultaneous determination of eight β-lactam antibiotics in human plasma and cerebrospinal fluid by liquid chromatography coupled to tandem mass spectrometry
Simultaneous determination of eight β-lactam antibiotics in human plasma and cerebrospinal fluid by liquid chromatography coupled to tandem mass spectrometry Open
View article: Population Pharmacokinetic Study of Cefazolin Dosage Adaptation in Bacteremia and Infective Endocarditis Based on a Nomogram
Population Pharmacokinetic Study of Cefazolin Dosage Adaptation in Bacteremia and Infective Endocarditis Based on a Nomogram Open
Optimal dosing of continuous-infusion cefazolin can be challenging in patients being treated for bacteremia or infective endocarditis. The aim of this work is to describe and analyze the pharmacokinetics of cefazolin in those patients usin…
View article: Pharmacokinetic data on high dose baclofen administration in unhealthy alcohol user in the ICU
Pharmacokinetic data on high dose baclofen administration in unhealthy alcohol user in the ICU Open
View article: High-Dose Ceftriaxone for Bacterial Meningitis and Optimization of Administration Scheme Based on Nomogram
High-Dose Ceftriaxone for Bacterial Meningitis and Optimization of Administration Scheme Based on Nomogram Open
High dosages of ceftriaxone are used to treat central nervous system (CNS) infections. Dosage adaptation according to the glomerular filtration rate is currently not recommended. Ceftriaxone pharmacokinetics (PK) was investigated by a popu…
View article: High-Dosage Cefazolin Achieves Sufficient Cerebrospinal Diffusion To Treat an External Ventricular Drainage-Related <i>Staphylococcus aureus</i> Ventriculitis
High-Dosage Cefazolin Achieves Sufficient Cerebrospinal Diffusion To Treat an External Ventricular Drainage-Related <i>Staphylococcus aureus</i> Ventriculitis Open
A patient received continuous infusion of cefazolin 10 g then 8 g daily for an external ventricular drainage-related methicillin-susceptible Staphylococcus aureus (MSSA) ventriculitis. Median free concentrations in the cerebrospinal fluid …