Ronen Loebstein
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View article: Bleeding complications following intramuscular injections among hospitalized anticoagulated patients: a retrospective observational comparative study
Bleeding complications following intramuscular injections among hospitalized anticoagulated patients: a retrospective observational comparative study Open
Bleeding complications at site of IM injections among anticoagulated hospitalized patients are rare, and their risk is probably not higher compared to patients without anticoagulation.
View article: Factors affecting decisions of an HMO Drug Exemptions Committee on individual patient requests for coverage of non-formulary drugs
Factors affecting decisions of an HMO Drug Exemptions Committee on individual patient requests for coverage of non-formulary drugs Open
View article: A Gastroenterologist's guide to drug interactions of small molecules for inflammatory bowel disease
A Gastroenterologist's guide to drug interactions of small molecules for inflammatory bowel disease Open
Small molecule drugs are becoming increasingly used in the treatment of inflammatory bowel diseases (IBD). However, unlike monoclonal antibody drugs, which have few interactions with other medications, the pharmacokinetics of small molecul…
View article: Big data accessibility issues for key medical personnel
Big data accessibility issues for key medical personnel Open
View article: Factors affecting decisions of an HMO Drug Exemptions Committee on individual patient requests for coverage of non-formulary drugs
Factors affecting decisions of an HMO Drug Exemptions Committee on individual patient requests for coverage of non-formulary drugs Open
Background In Israel, coverage of health needs is delivered by four health maintenance organizations (HMOs), which are budgeted by the government according to the recommendations of the National Drug Formulary (NDF) Committee. For medicati…
View article: Pregnancy outcomes following gestational exposure to papaverine: An observational comparative study
Pregnancy outcomes following gestational exposure to papaverine: An observational comparative study Open
Aims Papaverine is indicated for abdominal pain of various aetiologies. However, data on maternal and foetal safety following gestational exposure are lacking. The aim was to examine whether first trimester exposure to papaverine is associ…
View article: Concomitant oral potassium chloride and anticholinergic therapy is associated with upper gastrointestinal bleeding: A cohort study
Concomitant oral potassium chloride and anticholinergic therapy is associated with upper gastrointestinal bleeding: A cohort study Open
Aim To determine whether oral potassium chloride (KCI) therapy with concomitant anticholinergic exposure among hospitalized patients is associated with an excess risk for upper gastrointestinal bleeding (UGIB). Methods A retrospective cont…
View article: Publisher Correction: Pyroglutamic acidosis as a cause for high anion gap metabolic acidosis: a prospective study
Publisher Correction: Pyroglutamic acidosis as a cause for high anion gap metabolic acidosis: a prospective study Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Is Pyroglutamic Acid a Prognostic Factor Among Patients with Suspected Infection? A Prospective Cohort Study
Is Pyroglutamic Acid a Prognostic Factor Among Patients with Suspected Infection? A Prospective Cohort Study Open
View article: Clinically significant incidental QTc prolongation is subject to within‐individual variability
Clinically significant incidental QTc prolongation is subject to within‐individual variability Open
Background Prolonged QTc interval observed in daily practice is often deemed to be drug induced and might result in drug discontinuation, with possible therapeutic consequences. However, whether clinically significant prolonged QTc may be …
View article: PB2282 REASSESSING THE EFFICACY OF LOW DOSE RASBURICASE FOR MANAGEMENT OF TUMOR LYSIS SYNDROME IN HIGH RISK HEMATOLOGIC MALIGNANCIES
PB2282 REASSESSING THE EFFICACY OF LOW DOSE RASBURICASE FOR MANAGEMENT OF TUMOR LYSIS SYNDROME IN HIGH RISK HEMATOLOGIC MALIGNANCIES Open
Background: Tumor lysis syndrome (TLS) is a potentially life‐threatening metabolic derangement seen in aggressive hematologic malignancies which is characterized by the massive release of toxic metabolic byproducts and consequent kidney da…
View article: Pyroglutamic acidosis as a cause for high anion gap metabolic acidosis: a prospective study
Pyroglutamic acidosis as a cause for high anion gap metabolic acidosis: a prospective study Open
5-oxoprolinemia (pyroglutamic acid, PGA) in the absence of acetaminophen use has been rarely reported as a cause for high anion gap metabolic acidosis. We investigated the prevalence and risk factors for elevated PGA concentrations among h…
View article: Intrapatient variability in tacrolimus trough levels after solid organ transplantation varies at different postoperative time periods
Intrapatient variability in tacrolimus trough levels after solid organ transplantation varies at different postoperative time periods Open
To the Editor: We thank Lemaitre et al1Lemaitre F, Tron C, Jezequel C, Verdier CM, Rayer M. Intra-patient variability in solid-organ transplantation: should we make the first move earlier [published online ahead of print 2018]? Am J Transp…
View article: High tacrolimus trough level variability is associated with rejections after heart transplant
High tacrolimus trough level variability is associated with rejections after heart transplant Open
Tacrolimus, the major immunosuppressant after heart transplant (HTx) therapy, is a narrow therapeutic index drug. Hence, achieving stable therapeutic steady state plasma concentrations is essential to ensure efficacy while avoiding toxicit…
View article: Trends in annual drug expenditure – a 16 year perspective of a public healthcare maintenance organization
Trends in annual drug expenditure – a 16 year perspective of a public healthcare maintenance organization Open
View article: Induction infliximab levels among patients with acute severe ulcerative colitis compared with patients with moderately severe ulcerative colitis
Induction infliximab levels among patients with acute severe ulcerative colitis compared with patients with moderately severe ulcerative colitis Open
Summary Background Infliximab is effective as salvage therapy for patients with steroid refractory acute severe ulcerative colitis ( UC ). Although current data suggest that the pharmacokinetics of infliximab are influenced by inflammatory…
View article: Ashkenazi Jewish Origin Protects Against Formation of Antibodies to Infliximab and Therapy Failure
Ashkenazi Jewish Origin Protects Against Formation of Antibodies to Infliximab and Therapy Failure Open
Infliximab is an anti-tumor necrosis factor (TNF) used for treatment of inflammatory bowel disease (IBD) as well as rheumatoid arthritis, psoriasis, and other inflammatory conditions. Antibodies to infliximab (ATI) develop in approximately…
View article: Tu1278 Infliximab and Adalimumab Serum Levels Predict Probability of Mucosal Healing
Tu1278 Infliximab and Adalimumab Serum Levels Predict Probability of Mucosal Healing Open