Ronen R. Leker
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View article: Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection
Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection Open
Importance Fibromuscular dysplasia (FMD) is found in 6 to 14% of patients with spontaneous cervical artery dissection (SCEAD) and may be associated with recurrent SCEAD. Objective To evaluate the correlates of FMD in patients with SCEAD an…
View article: Revascularization Treatment of Basilar Artery Occlusion in Patients with Mild‐to‐Moderate Severe Stroke
Revascularization Treatment of Basilar Artery Occlusion in Patients with Mild‐to‐Moderate Severe Stroke Open
BACKGROUND The benefit of endovascular thrombectomy (EVT) in patients with basilar artery occlusion and severe neurological deficits is well established. However, its effectiveness in those with mild‐to‐moderate deficits remains uncertain.…
View article: Safety of endovascular therapy in ischemic stroke patients ⩾90 years: A cohort study from the EVA-TRISP collaboration
Safety of endovascular therapy in ischemic stroke patients ⩾90 years: A cohort study from the EVA-TRISP collaboration Open
Introduction: Data on safety of endovascular therapy (EVT) in the very elderly are scarce. Using data from a large prospective EVT registry, we aimed at providing better evidence for EVT decision-making in patients aged 90 years and older.…
View article: Long-Term Risk of Recurrent Cervical Artery Dissection and Stroke After Pregnancy
Long-Term Risk of Recurrent Cervical Artery Dissection and Stroke After Pregnancy Open
Importance Cervical artery dissection (CeAD) is a leading cause of stroke in young people and can occur during pregnancy. In women with prior CeAD, it is unclear whether future pregnancies increase the risk of recurrent CeAD, stroke, or de…
View article: Sex differences in outcomes after endovascular therapy with prior antiplatelet use: A study from the EVA-TRISP registry
Sex differences in outcomes after endovascular therapy with prior antiplatelet use: A study from the EVA-TRISP registry Open
Introduction: This study assessed sex differences in outcomes after mechanical thrombectomy (MT) with prior antiplatelet use using the EVA-TRISP multinational registry. Patients and methods: A cohort of consecutive patients (2015–2023) tre…
View article: Biological Sex and Outcomes in Patients with Extracranial Cervical Arterial Dissections
Biological Sex and Outcomes in Patients with Extracranial Cervical Arterial Dissections Open
Background and Aims: Cervical arterial dissections (CeAD) are a common cause of stroke in young adults across both sexes. Whether biological sex plays a role in the pathogenesis and outcome of CeAD remains unclear. Methods: In this retrosp…
View article: Missing in action: the genetic mysteries of extremely low HDL cholesterol
Missing in action: the genetic mysteries of extremely low HDL cholesterol Open
Introduction High-Density Lipoprotein Cholesterol (HDL-C) plays a pivotal role in cardiovascular health, acting as a key component in lipid transport and atheroprotection. While low HDL-C levels in the general population are often the resu…
View article: The Importance of Timing in Performing a Holter ECG in Patients Diagnosed with an Embolic Stroke of Undetermined Source
The Importance of Timing in Performing a Holter ECG in Patients Diagnosed with an Embolic Stroke of Undetermined Source Open
Background/Objectives: Previously undiagnosed atrial fibrillation (PUAF) is a significant cause of embolic stroke of undetermined source (ESUS). This study aimed to determine whether early heart rhythm monitoring with a Holter ECG after ac…
View article: Endovascular treatment for isolated cervical internal carotid artery occlusion: ETIICA study
Endovascular treatment for isolated cervical internal carotid artery occlusion: ETIICA study Open
Introduction: Evidence regarding the benefit of endovascular therapy (EVT) in patients with acute ischemic stroke (AIS) due to isolated cervical internal carotid artery occlusion (c-ICA-O) is lacking. We assessed the outcomes and safety of…
View article: Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels
Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels Open
In persons with stroke with occlusion of medium or distal vessels, EVT did not result in a lower level of disability or a lower incidence of death than best medical treatment alone. (Funded by the Swiss National Science Foundation and othe…
View article: Predictors of acute symptomatic seizure in cerebral venous thrombosis patients—a multicenter cohort study
Predictors of acute symptomatic seizure in cerebral venous thrombosis patients—a multicenter cohort study Open
Background: Acute symptomatic seizures (ASYS) is a common presentation in cerebral sinus venous thrombosis (CSVT) patients. Objectives: We aimed to characterize CSVT patients experiencing ASYS within 7 days from presentation. Additionaly, …
View article: Association of CT perfusion parameters with outcomes in patients with medium vessel occlusion undergoing endovascular thrombectomy
Association of CT perfusion parameters with outcomes in patients with medium vessel occlusion undergoing endovascular thrombectomy Open
Background: Imaging biomarkers obtained on computed tomography perfusion (CTP) have proven effective in predicting outcomes after endovascular thrombectomy (EVT) in patients with large vessel occlusion stroke. However, the association of C…
View article: Intravenous thrombolysis in young adults with ischemic stroke: A cohort study from the international TRISP collaboration
Intravenous thrombolysis in young adults with ischemic stroke: A cohort study from the international TRISP collaboration Open
Background and aims: Previous observational data indicate that young adults treated with intravenous thrombolysis (IVT) for acute ischemic stroke have more favorable outcomes and less complications when compared to older adults. Given the …
View article: Endovascular therapy in patients with acute intracranial non-terminal internal carotid artery occlusion (ICA-I)
Endovascular therapy in patients with acute intracranial non-terminal internal carotid artery occlusion (ICA-I) Open
Background: Acute intracranial occlusion of the internal carotid artery (ICA) can be distinguished into (a) occlusion of the terminal ICA, involving the proximal segments of the middle or anterior cerebral artery (ICA-L/-T) and (b) non-ter…
View article: Corrigendum: Direct oral anticoagulants for the treatment of cerebral venous thrombosis – a protocol of an international phase IV study
Corrigendum: Direct oral anticoagulants for the treatment of cerebral venous thrombosis – a protocol of an international phase IV study Open
[This corrects the article DOI: 10.3389/fneur.2023.1251581.].
View article: Endovascular treatment in patients with acute ischemic stroke presenting beyond 6 h after symptom onset: An international multicenter cohort study of the EVA-TRISP collaboration
Endovascular treatment in patients with acute ischemic stroke presenting beyond 6 h after symptom onset: An international multicenter cohort study of the EVA-TRISP collaboration Open
Introduction: After positive findings in clinical trials the time window for endovascular thrombectomy (EVT) for patients with an acute ischemic stroke has been expanded up to 24 h from symptom onset or last seen well (LSW). We aimed to co…
View article: Predictors of Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection
Predictors of Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection Open
Objective Patients with cervical artery dissection (CAD) are at increased ischemic stroke risk. We aimed to identify characteristics that are associated with increased risk of ischemic stroke following initial presentation of CAD and to ev…
View article: Are There Differences between Traumatic and Spontaneous Cervical Artery Dissections?
Are There Differences between Traumatic and Spontaneous Cervical Artery Dissections? Open
(1) Background: Cervical arterial dissections (CeAD) are a common cause of stroke in young adults. CeAD can be spontaneous (sCeAD) or traumatic (tCeAD). Whether CeAD subtypes differ in clinical, radiological, and outcome characteristics re…
View article: Corrigendum: Tandem occlusions involving the internal carotid and anterior cerebral arteries—A rare form of stroke: results from the multicenter EVATRISP collaboration study
Corrigendum: Tandem occlusions involving the internal carotid and anterior cerebral arteries—A rare form of stroke: results from the multicenter EVATRISP collaboration study Open
[This corrects the article DOI: 10.3389/fneur.2022.1024891.].
View article: Efficacy and safety of Apixaban in the treatment of cerebral venous sinus thrombosis: a multi-center study
Efficacy and safety of Apixaban in the treatment of cerebral venous sinus thrombosis: a multi-center study Open
Background Information regarding the safety and efficacy of specific direct oral anticoagulants (DOAC) in the treatment of cerebral sinus and venous thrombosis (CSVT) is scarce. Apixaban is one of the most frequently prescribed DOACs. Ther…
View article: EnDovascular therapy plus best medical treatment (BMT) versus BMT alone for medIum distal veSsel occlusion sTroke (DISTAL): An international, multicentre, randomized-controlled, two-arm, assessor-blinded trial
EnDovascular therapy plus best medical treatment (BMT) versus BMT alone for medIum distal veSsel occlusion sTroke (DISTAL): An international, multicentre, randomized-controlled, two-arm, assessor-blinded trial Open
Rationale: Whether endovascular therapy (EVT) in addition to best medical treatment (BMT) in people with acute ischemic stroke (AIS) due to a medium distal vessel occlusion (MDVO) is beneficial remains unclear. Aim: To determine if people …
View article: Reducing the global burden of cerebral venous thrombosis: An international research agenda
Reducing the global burden of cerebral venous thrombosis: An international research agenda Open
Background: Due to the rarity of cerebral venous thrombosis (CVT), performing high-quality scientific research in this field is challenging. Providing answers to unresolved research questions will improve prevention, diagnosis, and treatme…
View article: Diagnostic Yield of High-Resolution Vessel Wall Magnetic Resonance Imaging in the Evaluation of Young Stroke Patients
Diagnostic Yield of High-Resolution Vessel Wall Magnetic Resonance Imaging in the Evaluation of Young Stroke Patients Open
(1) Background: The mechanism responsible for stroke in patients younger than 50 often remains unknown. This study was designed to assess whether high-resolution intracranial vessel wall MR imaging (icVWI) may be instrumental in determinin…
View article: Urgent Off-Label Use of Flow–Diverter Stents in the Endovascular Management of Tonsillar Loop-Associated Internal Carotid Artery Dissections Presenting with Carotid Occlusion or Near-Occlusion and Major Ischemic Stroke
Urgent Off-Label Use of Flow–Diverter Stents in the Endovascular Management of Tonsillar Loop-Associated Internal Carotid Artery Dissections Presenting with Carotid Occlusion or Near-Occlusion and Major Ischemic Stroke Open
We present our experience with the implantation of flow diverter stents (FDSs) for the management of internal carotid artery (ICA) dissections in tortuous tonsillar loop segments. A total of 16 patients (10 women, 62.5%; mean age 39 ± 8 ye…
View article: Direct oral anticoagulants for the treatment of cerebral venous thrombosis – a protocol of an international phase IV study
Direct oral anticoagulants for the treatment of cerebral venous thrombosis – a protocol of an international phase IV study Open
Introduction Current guidelines recommend that patients with cerebral venous thrombosis (CVT) should be treated with vitamin K antagonists (VKAs) for 3–12 months. Direct oral anticoagulants (DOACs), however, are increasingly used in clinic…
View article: P11.69.B INTRAVENOUS THROMBOLYSIS WITH OR WITHOUT ENDOVASCULAR TREATMENT FOR SUSPECTED ISCHEMIC STROKE IN PATIENTS WITH INTRACRANIAL TUMORS
P11.69.B INTRAVENOUS THROMBOLYSIS WITH OR WITHOUT ENDOVASCULAR TREATMENT FOR SUSPECTED ISCHEMIC STROKE IN PATIENTS WITH INTRACRANIAL TUMORS Open
BACKGROUND: AND OBJECTIVES Intravenous thrombolysis (IVT) for suspected ischemic stroke in patients with intracranial neoplasms is off-label. However, data on risks of intracranial hemorrhage (ICH) is scarce. METHODS In a multicenter regis…
View article: IV Thrombolysis With or Without Endovascular Treatment for Suspected Ischemic Stroke in Patients With Intracranial Tumors
IV Thrombolysis With or Without Endovascular Treatment for Suspected Ischemic Stroke in Patients With Intracranial Tumors Open
In our dataset from routine clinical care, we provide insights on the safety of IVT for suspected ischemic stroke in patients with intracranial tumors, a population that is commonly withheld thrombolysis in clinical practice and prospectiv…
View article: Does Malignancy Status Effect Outcomes in Patients With Large Vessel Occlusion Stroke and Cancer Who Underwent Endovascular Thrombectomy?
Does Malignancy Status Effect Outcomes in Patients With Large Vessel Occlusion Stroke and Cancer Who Underwent Endovascular Thrombectomy? Open
Background Cancer is associated with an increased risk of acute ischemic stroke, including large vessel occlusions. Whether cancer status affects outcomes in patients with large vessel occlusions that undergo endovascular thrombectomy rema…
View article: Safety and effectiveness of IV Thrombolysis in retinal artery occlusion: A multicenter retrospective cohort study
Safety and effectiveness of IV Thrombolysis in retinal artery occlusion: A multicenter retrospective cohort study Open
Background: Retinal artery occlusion (RAO) may lead to irreversible blindness. For acute RAO, intravenous thrombolysis (IVT) can be considered as treatment. However, due to the rarity of RAO, data about IVT safety and effectiveness is limi…
View article: Urgent Off-Label Use of Flow−Diverter Stents In the Endovascular Management of Tonsillar Loop-Associated Internal Carotid Artery Dissections Presenting with Carotid Occlusion or Near-Occlusion and Major Ischemic Stroke
Urgent Off-Label Use of Flow−Diverter Stents In the Endovascular Management of Tonsillar Loop-Associated Internal Carotid Artery Dissections Presenting with Carotid Occlusion or Near-Occlusion and Major Ischemic Stroke Open
We present our experience with the implantation of flow diverter stents (FDSs) for the management of intern carotid artery (ICA) dissections in tortuous tonsillar loop segments. 16 patients (10 women, 62.5%; mean age 39±8 years; median bas…