Zhenhua Jia
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View article: The role of pulmonary vascular endothelial cell injury in COPD and its targeted therapeutic strategies
The role of pulmonary vascular endothelial cell injury in COPD and its targeted therapeutic strategies Open
Chronic obstructive pulmonary disease (COPD) is a common disease with a high global incidence and mortality rate. It is characterized by chronic inflammation and structural airway obstruction that is not fully reversible, leading to shortn…
View article: Top 10 academic advances in traditional Chinese medicine in 2024
Top 10 academic advances in traditional Chinese medicine in 2024 Open
View article: Cost‐Effectiveness and Cost‐Utility Analysis of Tongxinluo Capsules Compared With Conventional Therapy for the Treatment of Acute Myocardial Infarction
Cost‐Effectiveness and Cost‐Utility Analysis of Tongxinluo Capsules Compared With Conventional Therapy for the Treatment of Acute Myocardial Infarction Open
Aim Tongxinluo (TXL) capsule, a traditional Chinese medicine compound, has proven effective in acute myocardial infarction (AMI), but its cost‐effectiveness is unclear. Methods This economic evaluation utilized individual data from clinica…
View article: Multi-dimensional PK-PD insights into Lianhua Qingwen's formula compatibility
Multi-dimensional PK-PD insights into Lianhua Qingwen's formula compatibility Open
Using an integrated formula-disassembled strategy and PK-PD analysis, we systematically deciphered LHQW's compatibility principle: YQP, MXSGD, and Dahuang exert distinct therapeutic effects and synergistic mechanisms; intact LHQW's optimiz…
View article: Enterococcus faecium as a causative agent of death of Small-Tailed Han sheep farmed in Tongliao region of China: A case study
Enterococcus faecium as a causative agent of death of Small-Tailed Han sheep farmed in Tongliao region of China: A case study Open
In order to determine the cause of death of 27 Small-Tailed Han sheep in a Small-Tailed Han sheep farm in Tongliao, China, we characterized Gram-positive coccobacillus isolated from dead Small-Tailed Han sheep. We have also conducted a pre…
View article: Study design and rationale of the TXL-CAP trial: a randomized, double-blind, placebo-controlled, multicenter clinical trial assessing the effect of Tongxinluo capsules on the stability of coronary atherosclerotic plaques
Study design and rationale of the TXL-CAP trial: a randomized, double-blind, placebo-controlled, multicenter clinical trial assessing the effect of Tongxinluo capsules on the stability of coronary atherosclerotic plaques Open
Recent clinical trials have demonstrated a protective effect in using traditional Chinese medicine Tongxinluo (TXL) capsule to treat atherosclerosis. However, clinical evidence of the effects of TXL treatment on coronary plaque vulnerabili…
View article: Protective role of Tongxinluo in mitigating myocardial fibrosis in mice with acute myocardial infarction via neuregulin-1 upregulation and Inhibition of endothelium-interstitial transition
Protective role of Tongxinluo in mitigating myocardial fibrosis in mice with acute myocardial infarction via neuregulin-1 upregulation and Inhibition of endothelium-interstitial transition Open
View article: Senescent alveolar type II epithelial cells-secreted GDF15 promotes silicosis progression via interfering intercellular communication
Senescent alveolar type II epithelial cells-secreted GDF15 promotes silicosis progression via interfering intercellular communication Open
Our results elucidate that senescence ATII cell-secreted GDF15 plays a vital role in promoting silicosis by influencing surrounding cells, and provides scientific clues for the selection of potential therapeutic drugs for silicosis.
View article: Lianhua Qingke Tablet in severe pneumonia: Clinical efficacy and immunoregulatory mechanisms
Lianhua Qingke Tablet in severe pneumonia: Clinical efficacy and immunoregulatory mechanisms Open
LHQK demonstrates therapeutic efficacy in severe pneumonia by maintaining structural integrity, suppressing cytokine storms, enhancing intrinsic immunity, reversing T cell exhaustion, and correcting lung immune disorders. These findings si…
View article: Unveiling the role of the <i>TIR1/AFB</i> gene family in <i>Capsicum annuum</i>: genome-wide identification, characterization, and transcriptomic analysis under <i>Ralstonia solanacearum</i> infection
Unveiling the role of the <i>TIR1/AFB</i> gene family in <i>Capsicum annuum</i>: genome-wide identification, characterization, and transcriptomic analysis under <i>Ralstonia solanacearum</i> infection Open
View article: The effectiveness of vasodilators on chronic obstructive pulmonary disease: A systematic review and meta-analysis
The effectiveness of vasodilators on chronic obstructive pulmonary disease: A systematic review and meta-analysis Open
Background: Chronic obstructive pulmonary disease (COPD) is a complex progressive disease. Some vasodilators have been reported with therapeutic potential to protect vascular function therefore may delay the progression of COPD. Methods: W…
View article: Therapeutic effects of Lianhua Qingke on COPD and influenza virus-induced exacerbation of COPD are associated with the inhibition of NF-κB signaling and NLRP3 inflammasome responses
Therapeutic effects of Lianhua Qingke on COPD and influenza virus-induced exacerbation of COPD are associated with the inhibition of NF-κB signaling and NLRP3 inflammasome responses Open
Lianhua Qingke (LHQK), a traditional Chinese medicine (TCM) used clinically for the treatment of respiratory diseases with acute tracheobronchitis, and cough, has demonstrated promising efficacy in suppressing inflammation, inhibitingmucin…
View article: Translational Research and Clinical Application of Traditional Chinese Medicine in Cardiovascular Diseases
Translational Research and Clinical Application of Traditional Chinese Medicine in Cardiovascular Diseases Open
Luobing theory is based on the principles of traditional Chinese medicine (TCM) and focuses on the regulation of blood circulation. The translation of Luobing theory into clinical practice has shown promising results in the treatment of ca…
View article: Atrial tachyarrhythmia prevention by Shensong Yangxin after catheter ablation for persistent atrial fibrillation: the SS-AFRF trial
Atrial tachyarrhythmia prevention by Shensong Yangxin after catheter ablation for persistent atrial fibrillation: the SS-AFRF trial Open
Background and Aims Despite advances in technology and techniques, the recurrence rate of persistent atrial fibrillation (AF) following catheter ablation remains high. The Shensong Yangxin (SSYX) capsule, a renowned traditional Chinese med…
View article: Shensong yangxin, a multi-functional traditional Chinese medicine for arrhythmia: A review of components, pharmacological mechanisms, and clinical applications
Shensong yangxin, a multi-functional traditional Chinese medicine for arrhythmia: A review of components, pharmacological mechanisms, and clinical applications Open
View article: The traditional Chinese medicine Qiliqiangxin in heart failure with reduced ejection fraction: a randomized, double-blind, placebo-controlled trial
The traditional Chinese medicine Qiliqiangxin in heart failure with reduced ejection fraction: a randomized, double-blind, placebo-controlled trial Open
Previous findings have indicated the potential benefits of the Chinese traditional medicine Qiliqiangxin (QLQX) in heart failure. Here we performed a double-blind, randomized controlled trial to evaluate the efficacy and safety of QLQX in …
View article: Tongxinluo capsule as a multi-functional traditional Chinese medicine in treating cardiovascular disease: A review of components, pharmacological mechanisms, and clinical applications
Tongxinluo capsule as a multi-functional traditional Chinese medicine in treating cardiovascular disease: A review of components, pharmacological mechanisms, and clinical applications Open
View article: Jinlida for Diabetes Prevention in Impaired Glucose Tolerance and Multiple Metabolic Abnormalities
Jinlida for Diabetes Prevention in Impaired Glucose Tolerance and Multiple Metabolic Abnormalities Open
Importance Previous studies have shown that Jinlida (JLD) granules, an approved treatment for type 2 diabetes in China, can reduce blood glucose level, reduce glycated hemoglobin (HbA 1c ), and improve insulin resistance in people with typ…
View article: Carrier Phase Dual One-Way Ranging Method Based on a Frequency Hopping Signal
Carrier Phase Dual One-Way Ranging Method Based on a Frequency Hopping Signal Open
With the development of navigation satellite constellation systems, to improve navigation service and orbit determination performance, the accuracy requirements for maintaining temporal references have increased rapidly. Among the current …
View article: Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice
Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice Open
The present study revealed the ameliorative effects of eldecalcitol on senescence and the associated ferroptosis of osteocytes, contributing to its preservation against osteoporosis of D-gal-induced senescent ovariectomized mice.
View article: People are an organic unity: Gut-lung axis and pneumonia
People are an organic unity: Gut-lung axis and pneumonia Open
People are an organic unity. Every organ of our body doesn't exist alone. They are a part of our body and have important connections with other tissues or organs. The gut-lung axis is a typical example. Here, we reviewed the current resear…
View article: The Effect of Bacterial AHL on the Cyclic Adenosine Monophosphate Content in Plants According to High-Performance Liquid Chromatography
The Effect of Bacterial AHL on the Cyclic Adenosine Monophosphate Content in Plants According to High-Performance Liquid Chromatography Open
Cyclic adenosine monophosphate (cAMP) is an important second messenger in cells, mediating various stimulation signals such as the growth and development of organisms and stress and participating in regulating various biological processes …
View article: <i>Angelica keiskei</i> water extract Mitigates Age-Associated Physiological Decline in Mice
<i>Angelica keiskei</i> water extract Mitigates Age-Associated Physiological Decline in Mice Open
Our findings indicated the potential of Angelica keiskei as a safe and effective dietary supplement to combat aging and revealed the broad prospects of medicinal and edible plants for addressing aging and age-related chronic diseases.
View article: Lianhua Qingke Preserves Mucociliary Clearance in Rat with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Maintaining Ciliated Cells Proportion and Protecting Structural Integrity and Beat Function of Cilia
Lianhua Qingke Preserves Mucociliary Clearance in Rat with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Maintaining Ciliated Cells Proportion and Protecting Structural Integrity and Beat Function of Cilia Open
LHQK enhances the MCC capability of ciliated cells in rat with AECOPD by preserving the structural integrity and beating function of cilia, indicating its therapeutic potential on promoting sputum expulsion in patients with AECOPD.
View article: The Aesthetic Characteristics and Limitations of Film Adaptations of Classic Literature: A Case Study of The Great Gatsby
The Aesthetic Characteristics and Limitations of Film Adaptations of Classic Literature: A Case Study of The Great Gatsby Open
Under the commercial development of today's film industry and the purpose of recreating excellent texts, there are many film adaptations based on excellent classic literary works. These adaptations attract both literary and film and televi…
View article: Association between peripheral inflammation and body mass index on white matter integrity and free water in bipolar II depression
Association between peripheral inflammation and body mass index on white matter integrity and free water in bipolar II depression Open
View article: Prediction of clinical outcomes after gastrointestinal surgery in the elderly patients based on a deep learning CT diagnosis model for sarcopenia
Prediction of clinical outcomes after gastrointestinal surgery in the elderly patients based on a deep learning CT diagnosis model for sarcopenia Open
View article: Green fabrication of chitosan microcapsules via double emulsion-simple coacervation and their application in fabrics
Green fabrication of chitosan microcapsules via double emulsion-simple coacervation and their application in fabrics Open
View article: Synaptotagmin 1 Suppresses Colorectal Cancer Metastasis by Inhibiting ERK/MAPK Signaling-Mediated Tumor Cell Pseudopodial Formation and Migration
Synaptotagmin 1 Suppresses Colorectal Cancer Metastasis by Inhibiting ERK/MAPK Signaling-Mediated Tumor Cell Pseudopodial Formation and Migration Open
Although synaptotagmin 1 (SYT1) has been identified participating in a variety of cancers, its role in colorectal cancer (CRC) remains an enigma. This study aimed to demonstrate the effect of SYT1 on CRC metastasis and the underlying mecha…
View article: Therapeutic potential of Lianhua Qingke in airway mucus hypersecretion of acute exacerbation of chronic obstructive pulmonary disease
Therapeutic potential of Lianhua Qingke in airway mucus hypersecretion of acute exacerbation of chronic obstructive pulmonary disease Open