Li Deng
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View article: Bacteria and bacteriophage consortia modulate cecal SCFA production and host metabolism to enhance feed efficiency in ducks
Bacteria and bacteriophage consortia modulate cecal SCFA production and host metabolism to enhance feed efficiency in ducks Open
Background: The gut microbiota critically influences poultry health, nutrition, feed efficiency (FE), and overall productivity. However, the relationship between gut microbes, including bacteria and bacteriophages, and FE in ducks remains …
View article: Bakteriophagen zur Behandlung muskuloskelettaler Infektionen – Eine Übersicht zu klinischem Einsatz, offenen Fragen und rechtlichem Rahmen
Bakteriophagen zur Behandlung muskuloskelettaler Infektionen – Eine Übersicht zu klinischem Einsatz, offenen Fragen und rechtlichem Rahmen Open
Zusammenfassung Hintergrund Bakteriophagen, kurz Phagen, sind hochspezifische Viren, die gezielt Bakterien infizieren und lysieren. Ihre Wiederentdeckung als therapeutische Option gewinnt angesichts zunehmender Antibiotikaresistenzen an Dy…
View article: The role of three-dimensional printing models in medical education: a systematic review and meta-analysis of randomized controlled trials
The role of three-dimensional printing models in medical education: a systematic review and meta-analysis of randomized controlled trials Open
3DPMs serve as a valuable adjunct to traditional teaching methodologies and have the potential to enhance both the theoretical understanding and practical laboratory skills of medical students. Nevertheless, caution must be exercised in in…
View article: Comparative evaluation of long-term preservation methods for morphologically distinct bacteriophages
Comparative evaluation of long-term preservation methods for morphologically distinct bacteriophages Open
The rapid increase in antibiotic resistance has led to a renewed interest in phage therapy, which has created a need for the establishment of phage collections in order to preserve diverse phages and to reduce the delivery time to patients…
View article: PCSK9 with a gain of function D374Y mutation aggravates atherosclerosis by inhibiting PPARα expression
PCSK9 with a gain of function D374Y mutation aggravates atherosclerosis by inhibiting PPARα expression Open
View article: Repetitive transcranial magnetic stimulation for motor function in stroke: a systematic review and meta-analysis of randomized controlled studies
Repetitive transcranial magnetic stimulation for motor function in stroke: a systematic review and meta-analysis of randomized controlled studies Open
View article: Bacterial Community Composition and Its Relationship with Environmental Factors in the Artificial Reef Area for Marine Ranching in Changhai County
Bacterial Community Composition and Its Relationship with Environmental Factors in the Artificial Reef Area for Marine Ranching in Changhai County Open
In this study, samples were collected from different types of artificial fish reefs and prevention and control areas in the sea areas of the northern part of Da Changshan Island and the northeastern part of Xiao Changshan Island in the Nor…
View article: Homochiral metalated tetraphenylethylene‐based organic cages: Unusual chiral and luminescent behavior depending on thermodynamic and kinetic aggregation
Homochiral metalated tetraphenylethylene‐based organic cages: Unusual chiral and luminescent behavior depending on thermodynamic and kinetic aggregation Open
Chirality and luminescence are important for both chemistry and biology, which are highly influenced by aggregation. In this work, a pair of metalated tetraphenylethylene(TPE)‐based organic cage enantiomers are reported, which feature a qu…
View article: Homochiral Metalated Tetraphenylethylene-Based Organic Cages: Unusual Chiral and Luminescent Behavior Depending on Thermodynamic and Kinetic Aggregation
Homochiral Metalated Tetraphenylethylene-Based Organic Cages: Unusual Chiral and Luminescent Behavior Depending on Thermodynamic and Kinetic Aggregation Open
Chirality and luminescence are important for both chemistry and biology, which are highly influenced by aggregation. In this work, we reported a pair of metalated tetraphenylethylene(TPE)-based organic cage enantiomers, which feature a qua…
View article: Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer
Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer Open
Transition from traditional high-fiber to Western diets in urbanizing communities of Sub-Saharan Africa is associated with increased risk of non-communicable diseases (NCD), exemplified by colorectal cancer (CRC) risk. To investigate how u…
View article: Seroprevalence of severe acute respiratory syndrome coronavirus 2 IgG in Juba, South Sudan, 2020
Seroprevalence of severe acute respiratory syndrome coronavirus 2 IgG in Juba, South Sudan, 2020 Open
Relatively few coronavirus disease cases and deaths have been reported from sub-Saharan Africa, although the extent of its spread remains unclear. During August 10-Sep-tember 11, 2020, we recruited 2,214 participants for a representative h…
View article: Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health
Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health Open
View article: Changes in food quality and characterization under thermal accumulation conditions during Chinese cooking
Changes in food quality and characterization under thermal accumulation conditions during Chinese cooking Open
Chinese cooking is the primary treatment method for table food in China. The process is complex and large‐scale, which is important to the macroeconomy and national nutrition and health. First, this article puts forward the concept of ther…
View article: Boosting Microglial Lipid Metabolism via TREM2 Signaling by Biomimetic Nanoparticles to Attenuate the Sevoflurane‐Induced Developmental Neurotoxicity
Boosting Microglial Lipid Metabolism via TREM2 Signaling by Biomimetic Nanoparticles to Attenuate the Sevoflurane‐Induced Developmental Neurotoxicity Open
Lipid metabolism has been considered as a potential therapeutic target in sevoflurane‐induced neurotoxicity that can potentially affect the learning and memory function in the developmental brain. Recently, triggering receptor expressed on…
View article: The Potential of Bacteriophage Therapy as an Alternative Treatment Approach for Antibiotic-Resistant Infections
The Potential of Bacteriophage Therapy as an Alternative Treatment Approach for Antibiotic-Resistant Infections Open
Objective: This study aimed to provide a comprehensive overview of the current state of the literature on the therapeutical application of bacteriophages. Methods: First, a bibliometric analysis was performed us…
View article: Gut virome profiling identifies an association between temperate phages and colorectal cancer promoted by <i>Helicobacter pylori</i> infection
Gut virome profiling identifies an association between temperate phages and colorectal cancer promoted by <i>Helicobacter pylori</i> infection Open
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide. While a close correlation between chronic Helicobacter pylori infection and CRC has been reported, the role of the virome has been overlooked. Here, we…
View article: Unveiling the hidden role of aquatic viruses in hydrocarbon pollution bioremediation
Unveiling the hidden role of aquatic viruses in hydrocarbon pollution bioremediation Open
Hydrocarbon pollution poses substantial environmental risks to water and soil. Bioremediation, which utilizes microorganisms to manage pollutants, offers a cost-effective solution. However, the role of viruses, particularly bacteriophages …
View article: Targeted Single-Phage Isolation Reveals Phage-Dependent Heterogeneous Infection Dynamics
Targeted Single-Phage Isolation Reveals Phage-Dependent Heterogeneous Infection Dynamics Open
The spread of multidrug-resistant bacteria is a global human health threat, and without immediate action we are fast approaching a postantibiotic era. One possible alternative to antibiotics is the use of phages, that is, bacterial viruses.
View article: ViroProfiler: a containerized bioinformatics pipeline for viral metagenomic data analysis
ViroProfiler: a containerized bioinformatics pipeline for viral metagenomic data analysis Open
Bacteriophages play central roles in the maintenance and function of most ecosystems by regulating bacterial communities. Yet, our understanding of their diversity remains limited due to the lack of robust bioinformatics standards. Here we…
View article: Phage Therapy in Germany—Update 2023
Phage Therapy in Germany—Update 2023 Open
Bacteriophage therapy holds promise in addressing the antibiotic-resistance crisis, globally and in Germany. Here, we provide an overview of the current situation (2023) of applied phage therapy and supporting research in Germany. The auth…
View article: DeepsmirUD: Prediction of Regulatory Effects on microRNA Expression Mediated by Small Molecules Using Deep Learning
DeepsmirUD: Prediction of Regulatory Effects on microRNA Expression Mediated by Small Molecules Using Deep Learning Open
Aberrant miRNA expression has been associated with a large number of human diseases. Therefore, targeting miRNAs to regulate their expression levels has become an important therapy against diseases that stem from the dysfunction of pathway…
View article: Insights into the global freshwater virome
Insights into the global freshwater virome Open
Viruses are by far the most abundant life forms on this planet. Yet, the full viral diversity remains mostly unknown, especially in environments like freshwater. Therefore, we aimed to study freshwater viruses in a global context. To this …
View article: Toxic/Bioactive Peptide Synthesis Genes Rearranged by Insertion Sequence Elements Among the Bloom-Forming Cyanobacteria Planktothrix
Toxic/Bioactive Peptide Synthesis Genes Rearranged by Insertion Sequence Elements Among the Bloom-Forming Cyanobacteria Planktothrix Open
It has been generally hypothesized that mobile elements can induce genomic rearrangements and influence the distribution and functionality of toxic/bioactive peptide synthesis pathways in microbes. In this study, we performed in depth geno…
View article: Replidec - Use naive Bayes classifier to identify virus lifecycle from metagenomics data
Replidec - Use naive Bayes classifier to identify virus lifecycle from metagenomics data Open
Motivation Viruses are the most abundant biological entities on earth. The majority of these entities are bacterial viruses or phages which specifically infect bacteria. Phages can use different replication strategies to invade their hosts…
View article: Women in the European Virus Bioinformatics Center
Women in the European Virus Bioinformatics Center Open
Viruses are the cause of a considerable burden to human, animal and plant health, while on the other hand playing an important role in regulating entire ecosystems. The power of new sequencing technologies combined with new tools for proce…
View article: Altered virome structrue and function characterization in <i>Helicobacter pylori</i>-driven colorectal carcinogenesis and <i>H. pylori</i> eradication
Altered virome structrue and function characterization in <i>Helicobacter pylori</i>-driven colorectal carcinogenesis and <i>H. pylori</i> eradication Open
The understanding of gut virome and its role in Helicobacter pylori -driven colorectal cancer (CRC), as well as the long-term impact of H. pylori eradication via antibiotic treatment on it could contribute to better understanding the mecha…
View article: The role of virome in the gastrointestinal tract and beyond
The role of virome in the gastrointestinal tract and beyond Open
The human gut virome is comprised of diverse commensal and pathogenic viruses. The colonization by these viruses begins right after birth through vaginal delivery, then continues through breastfeeding, and broader environmental exposure. T…
View article: Emerging technologies in the study of the virome
Emerging technologies in the study of the virome Open
Despite the growing interest in the microbiome in recent years, the study of the virome, the major part of which is made up of bacteriophages, is relatively underdeveloped compared with their bacterial counterparts. This is due in part to …
View article: [Treatment of bone and periprosthetic infections with bacteriophages : A systematic review].
[Treatment of bone and periprosthetic infections with bacteriophages : A systematic review]. Open
View article: Alterations of host-gut microbiome interactions in multiple sclerosis
Alterations of host-gut microbiome interactions in multiple sclerosis Open