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View article: METTL14 overexpression identifies a biologically aggressive subgroup and correlates with adverse clinical outcomes in multiple myeloma
METTL14 overexpression identifies a biologically aggressive subgroup and correlates with adverse clinical outcomes in multiple myeloma Open
Background N⁶-methyladenosine (m⁶A) is the most prevalent internal modification of eukaryotic mRNA and plays a central role in post-transcriptional gene regulation. METTL14, a key component of the m⁶A methyltransferase complex, has been im…
View article: Mitochondrial mass in pre-lymphodepletion T cells predicts early response to CAR-T therapy in relapsed/refractory non-Hodgkin lymphoma
Mitochondrial mass in pre-lymphodepletion T cells predicts early response to CAR-T therapy in relapsed/refractory non-Hodgkin lymphoma Open
Background: Response heterogeneity to CAR-T therapy in relapsed/refractory non-Hodgkin lymphoma (R/R NHL) remains a major clinical challenge. This study investigates mitochondrial metabolism biomarkers—mitochondrial mass (MM) and membrane …
View article: 18F-prostate-specific membrane antigen-1007 positron emission tomography / computed tomography detects occult leptomeningeal metastases in poorly differentiated thyroid carcinoma misdiagnosed as vascular mimicry on magnetic resonance imaging
18F-prostate-specific membrane antigen-1007 positron emission tomography / computed tomography detects occult leptomeningeal metastases in poorly differentiated thyroid carcinoma misdiagnosed as vascular mimicry on magnetic resonance imaging Open
View article: RCN1 Binds KIF14 and Promotes the Malignant Growth of Cervical Cancer Through the PI3K-AKT Pathway
RCN1 Binds KIF14 and Promotes the Malignant Growth of Cervical Cancer Through the PI3K-AKT Pathway Open
RCN1 is significantly expressed in cervical cancer, which is associated with a poor prognosis, spread and recurrence. By promoting KIF14-induced activation of the PI3K-AKT-mTOR pathway, RCN1 may facilitate the malignant development of cerv…
View article: Tibremciclib or Placebo Plus Fulvestrant in Hormone Receptor–Positive and <i>ERBB2</i>-Negative Advanced Breast Cancer After Endocrine Therapy
Tibremciclib or Placebo Plus Fulvestrant in Hormone Receptor–Positive and <i>ERBB2</i>-Negative Advanced Breast Cancer After Endocrine Therapy Open
Importance Cyclin-dependent kinase (CDK) 4/6 inhibitors combined with endocrine therapy (ET) are now considered the standard treatment regimen for hormone receptor–positive (HR + ) and ERBB2 (formerly HER2 )–negative ( ERBB2 − ) advanced b…
View article: m<sup>6</sup>A‐modified EHD1 controls PD‐L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma
m<sup>6</sup>A‐modified EHD1 controls PD‐L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma Open
Background Eps15 homology domain (EHD) proteins, including EHD1 to EHD4, play vital roles in tumor progression. In this study, we aimed to investigate which specific EHD proteins, if any, are implicated in tumor immune evasion and immunoth…
View article: Pegylated liposomal doxorubicin + cyclophosphamide followed by taxane as adjuvant therapy for early-stage breast cancer: a randomized controlled trial
Pegylated liposomal doxorubicin + cyclophosphamide followed by taxane as adjuvant therapy for early-stage breast cancer: a randomized controlled trial Open
Background Pegylated liposomal doxorubicin (PLD) was shown to have comparable efficacy to doxorubicin, with significantly reduced cardiotoxicity. This study evaluated the cardiotoxicity and efficacy of the PLD-based regimen compared with t…
View article: LDHAL6B is a novel prognostic marker and promotes disease progression in multiple myeloma
LDHAL6B is a novel prognostic marker and promotes disease progression in multiple myeloma Open
Not available.
View article: RCN1 couple KIF14 and promotes the malignant progression of cervical cancer via the PI3K-mTOR pathway
RCN1 couple KIF14 and promotes the malignant progression of cervical cancer via the PI3K-mTOR pathway Open
Purpose: Cervical cancer ranks as the fourth leading cause of cancer-related mortality among women. While early-stage cases often respond well to therapy, advanced and recurrent disease remains challenging to manage. This study aimed to el…
View article: A Comprehensive Evaluation of Factors Affecting the Mental Status and Quality of Life in Breast Cancer Patients With Schizophrenia at Different Treatment Stages (Preoperative and Postoperative)
A Comprehensive Evaluation of Factors Affecting the Mental Status and Quality of Life in Breast Cancer Patients With Schizophrenia at Different Treatment Stages (Preoperative and Postoperative) Open
Objective: Surgery, as the preferred option to extend the survival of breast cancer patients, has increasingly garnered attention for its impact on patients' mental status and quality of life (QoL). Therefore, this study aimed to identify …
View article: A clinical study exploring the prediction of microvascular invasion in hepatocellular carcinoma through the use of combined enhanced CT and MRI radiomics
A clinical study exploring the prediction of microvascular invasion in hepatocellular carcinoma through the use of combined enhanced CT and MRI radiomics Open
Objective To develop a predictive model for microvascular invasion (MVI) in hepatocellular carcinoma (HCC) through radiomics analysis, integrating data from both enhanced computed tomography (CT) and magnetic resonance imaging (MRI). Metho…
View article: Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy
Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy Open
Background Itraconazole, a widely used antifungal medication, has shown potential in inhibiting tumor growth and reducing angiogenesis. However, its role in melanoma tumor growth remains insufficiently explored. This study investigates the…
View article: Targeting piRNA‐137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via <i>De Novo</i> Cholesterol Biosynthesis in Lung Adenocarcinoma
Targeting piRNA‐137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via <i>De Novo</i> Cholesterol Biosynthesis in Lung Adenocarcinoma Open
The important role of PIWI‐interacting RNAs (piRNAs) in tumors has garnered increasing attention. However, research on their role in lung adenocarcinoma (LUAD) remains limited. Elevated levels of piRNA‐137463 have been linked to poor progn…
View article: m<sup>6</sup>A‐Modified SNRPA Controls Alternative Splicing of ERCC1 Exon 8 to Induce Cisplatin Resistance in Lung Adenocarcinoma
m<sup>6</sup>A‐Modified SNRPA Controls Alternative Splicing of ERCC1 Exon 8 to Induce Cisplatin Resistance in Lung Adenocarcinoma Open
Alternative splicing (AS) generates protein diversity and is exploited by cancer cells to drive tumor progression and resistance to many cancer therapies, including chemotherapy. SNRPA is first identified as a spliceosome‐related gene that…
View article: RCN1 binds KIF14 to promote the malignant development of cervical cancer
RCN1 binds KIF14 to promote the malignant development of cervical cancer Open
Purpose The fourth most common cause of cancer-related deaths in women is cervical cancer. Though treatment of early-stage cervical cancer is often effective, middle and advanced stage cervical cancer is hard to treat and prone to recurren…
View article: Microsurgical Anatomy of the Common Tendinous Ring and Its Surgical Implications
Microsurgical Anatomy of the Common Tendinous Ring and Its Surgical Implications Open
BACKGROUND AND OBJECTIVES: The common tendinous ring (CTR), also known as the common annular tendon or annulus of Zinn, is a critical anatomic structure located at the convergence of the orbital apex, superior orbital fissure (SOF), optic …
View article: DUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma
DUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma Open
Background Lung adenocarcinoma (LUAD) patients have a dismal survival rate because of cancer metastasis and drug resistance. The study aims to identify the genes that concurrently modulate EMT, metastasis and EGFR-TKI resistance, and to in…
View article: Association Between ACE2 and Lung Diseases
Association Between ACE2 and Lung Diseases Open
Angiotensin-converting enzyme 2 (ACE2) is an important regulator of the Renin-Angiotensin System (RAS). Additionally, it has been identified as a functional receptor for the Coronavirus. Research indicates that ACE2 plays a role in the reg…
View article: Osteolytic lesions as a presenting sign of acute myeloid leukemia: a case report
Osteolytic lesions as a presenting sign of acute myeloid leukemia: a case report Open
Osteolytic lesions are infrequently observed in adult patients with acute myeloid leukemia (AML). This report details the case of a 66-year-old male patient who presented with myeloid sarcoma (MS), osteolytic lesion and pancytopenia. Effec…
View article: Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis
Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis Open
Our meta-analysis confirmed that the increased number of CPCs had a negative impact on the PFS and OS of MM patients. Therefore, CPCs could be a promising prognostic biomarker that helps with risk stratification and disease monitoring.
View article: Pyrotinib plus docetaxel as first-line treatment for HER2-positive metastatic breast cancer: the PANDORA phase II trial
Pyrotinib plus docetaxel as first-line treatment for HER2-positive metastatic breast cancer: the PANDORA phase II trial Open
The role of pyrotinib in the treatment of HER2-positive metastatic breast cancer (MBC) has been well-established. This multicenter, single-arm phase II trial (NCT03876587) aimed to assess the benefit of pyrotinib plus docetaxel as a first-…
View article: Study of neutron sensitivity for vanadium self-powered neutron detector in nuclear reactors
Study of neutron sensitivity for vanadium self-powered neutron detector in nuclear reactors Open
Vanadium self-powered neutron detectors (SPNDs) are widely used as in-core unmovable detectors in nuclear power plants to continuously carry out data monitoring of neutron flux and nuclear power. In this study, a theoretical calculation mo…
View article: Targeting PRMT1 prevents acute and chronic graft-versus-host disease
Targeting PRMT1 prevents acute and chronic graft-versus-host disease Open
View article: Analysis of signal cable noise currents in nuclear reactors under high neutron flux irradiation
Analysis of signal cable noise currents in nuclear reactors under high neutron flux irradiation Open
Cables are indispensable in nuclear power plants for transmitting data measured by various types of detectors, such as self-powered neutron detectors (SPNDs). These cables will generate disturbing signals that must be accurately distinguis…
View article: Real‐world treatment patterns and outcomes of pyrotinib‐based therapy in patients with <scp>HER2</scp>‐positive advanced breast cancer (<scp>PRETTY</scp>): A nationwide, prospective, observational study
Real‐world treatment patterns and outcomes of pyrotinib‐based therapy in patients with <span>HER2</span>‐positive advanced breast cancer (<span>PRETTY</span>): A nationwide, prospective, observational study Open
Pyrotinib, an irreversible pan‐ErbB inhibitor, has been approved for treating HER2‐positive advanced breast cancer in China. We conducted a nationwide, prospective observational study to examine the real‐world data of pyrotinib‐based thera…
View article: Molecular subtypes predict the preferential site of distant metastasis in advanced breast cancer: a nationwide retrospective study
Molecular subtypes predict the preferential site of distant metastasis in advanced breast cancer: a nationwide retrospective study Open
Objective This study aimed to explore possible associations between molecular subtypes and site of distant metastasis in advanced breast cancer (ABC). Methods 3577 ABC patients were selected from 21 hospitals of seven geographic regions in…
View article: Survival in Breast Cancer Patients with Bone Metastasis: A Multicenter Real-World Study on the Prognostic Impact of Intensive Postoperative Bone Scan after Initial Diagnosis of Breast Cancer (CSBrS-023)
Survival in Breast Cancer Patients with Bone Metastasis: A Multicenter Real-World Study on the Prognostic Impact of Intensive Postoperative Bone Scan after Initial Diagnosis of Breast Cancer (CSBrS-023) Open
The prognostic value of intensive postoperative bone scan (BS) screening, which is performed in asymptomatic patients with breast cancer (BC) after surgery, remained unclear. Patients diagnosed with BC with bone metastasis (BM) from five m…
View article: The effect of standard dose of neo/adjuvant chemotherapy on the benefit from capecitabine maintenance therapy: an exploratory analysis from SYSUCC-001 trial
The effect of standard dose of neo/adjuvant chemotherapy on the benefit from capecitabine maintenance therapy: an exploratory analysis from SYSUCC-001 trial Open
Aims: The addition of extended capecitabine after standard neo/adjuvant chemotherapy shows controversial results in triple-negative breast cancer (TNBC) patients between SYSUCC-001 trial and CIBOMA trial. Patients presents different respon…
View article: China is implementing the national nutrition plan of action
China is implementing the national nutrition plan of action Open
With the transformation of Chinese economic and social structure, the social determinants of nutrition have undergone significant changes, which have a great influence on the dietary patterns and nutrition status of its population. The tra…
View article: Age at initial diagnosis and prognosis of breast cancer: a nationwide multicenter retrospective study in China
Age at initial diagnosis and prognosis of breast cancer: a nationwide multicenter retrospective study in China Open
Age at initial diagnosis is related to the clinicopathological characteristics and treatment pattern. Although the risk of site-specific metastasis varies by age, age is not an independent factor influencing the risk of total recurrence an…