Peirong Lu
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View article: Uncorrected refractive errors, visual impairment and need for spectacles among children and adolescents in eastern, China
Uncorrected refractive errors, visual impairment and need for spectacles among children and adolescents in eastern, China Open
Background Uncorrected refractive errors (URE) are the leading preventable cause of visual impairment (VI) in children globally, with China facing a critical dual challenge of high myopia prevalence and insufficient spectacle coverage amon…
View article: Targeted metabolomics reveals dysregulated tryptophan metabolism in retinitis pigmentosa
Targeted metabolomics reveals dysregulated tryptophan metabolism in retinitis pigmentosa Open
Retinitis pigmentosa (RP) is an inherited retinal degenerative disease characterized by progressive retinal pigment epithelium dysfunction and photoreceptor apoptosis, yet its pathogenesis remains unclear and no cure exists. Emerging evide…
View article: Wheat straw incorporation enhances paddy soil quality: Evidence from a pot experiment
Wheat straw incorporation enhances paddy soil quality: Evidence from a pot experiment Open
Evaluating soil quality under various management practices in agroecosystems is crucial for understanding soil functioning. In this study, a soil quality index (SQI) was developed to assess the impact of wheat straw incorporation on soil q…
View article: B7-H3 Exacerbates Laser-Induced Choroidal Neovascularization by Promoting Macrophage Recruitment and Polarization via S100A8/A9
B7-H3 Exacerbates Laser-Induced Choroidal Neovascularization by Promoting Macrophage Recruitment and Polarization via S100A8/A9 Open
Introduction: This study investigates the role of the immune costimulatory factor B7-H3 in laser-induced choroidal neovascularization (CNV) and its underlying molecular mechanisms. Methods: A CNV model was established in C57BL/6J mice to e…
View article: Association between late age-related macular degeneration and dietary intake of copper, iron, zinc and selenium: a 2005–2008 NHANES cross-sectional observational study
Association between late age-related macular degeneration and dietary intake of copper, iron, zinc and selenium: a 2005–2008 NHANES cross-sectional observational study Open
Background Age-related macular degeneration (AMD) is a significant global cause of visual impairment. Our study seeks to explore the relationship between the intake of copper, iron, zinc, selenium in diet and late AMD. Method In this cross…
View article: AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway
AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway Open
The abnormal expression pattern of AZGP1 is critical for the development of SRF. Exogenous supplementation with AZGP1 may represent a promising strategy for ameliorating SRF by inhibiting EMT within RPE through the PI3K/AKT pathway.
View article: Amiodarone-related keratopathy and optic neuropathy: case report and literature review
Amiodarone-related keratopathy and optic neuropathy: case report and literature review Open
Amiodarone, a highly effective yet lipophilic antiarrhythmic drug with prolonged half-life, is associated with systemic and ocular complications. While keratopathy being the most prevalent, affecting 70–100% of long-term users, amiodarone-…
View article: Morphological alterations of macular region in fellow eyes of patients with idiopathic full-thickness macular holes detected by optical coherence tomography
Morphological alterations of macular region in fellow eyes of patients with idiopathic full-thickness macular holes detected by optical coherence tomography Open
AIM: To describe the optical coherence tomography (OCT) features in the fellow eyes of individuals with full-thickness macular holes (FTMHs). METHODS: This multicenter retrospective study included observational and validation groups, incor…
View article: Autophagy serves as a protective effect against inflammatory injury of oxidative stress in ARPE-19 cell
Autophagy serves as a protective effect against inflammatory injury of oxidative stress in ARPE-19 cell Open
AIM: To test the effect of autophagy on inflammatory damage resulting from oxidative stress in adult retinal pigment epithelial cell line (ARPE-19). METHODS: ARPE-19 cells were pretreated with 200 and 600 µmol/L hydrogen peroxide (H2O2) at…
View article: Prevalence and association of uncorrected refractive error among Chinese adolescents: a cross-sectional study
Prevalence and association of uncorrected refractive error among Chinese adolescents: a cross-sectional study Open
View article: Parents' or Guardians' Knowledge, Attitudes and Practices in the Prevention and Management of Childhood Myopia
Parents' or Guardians' Knowledge, Attitudes and Practices in the Prevention and Management of Childhood Myopia Open
Parents or guardians had adequate knowledge, a positive attitude, and proactive practices towards the prevention and management of childhood myopia, which might be affected by their educational level. This comprehensive understanding of pa…
View article: Resolution of myopic macular schisis following cataract phacoemulsification
Resolution of myopic macular schisis following cataract phacoemulsification Open
View article: Potential Mechanism of Platelet GPIIb/IIIa and Fibrinogen on Retinal Vein Occlusion
Potential Mechanism of Platelet GPIIb/IIIa and Fibrinogen on Retinal Vein Occlusion Open
To explore the role of coagulation and fibrinolytic factors, and the potential mechanism of platelet aggregation in the pathogenesis of retinal vein occlusion. Coagulation and fibrinolytic parameters in patients with retinal vein occlusion…
View article: Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription
Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription Open
Heightened lactate production in cancer cells has been linked to various cellular mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell dysfunction. The lactate‐induced lactylation of histone lysine residues is notew…
View article: Impact of PCSK9 and HMGCR Inhibition on Age-Related Macular Degeneration and Diabetic Retinopathy
Impact of PCSK9 and HMGCR Inhibition on Age-Related Macular Degeneration and Diabetic Retinopathy Open
View article: Trimethylamine N-oxide aggravates vascular permeability and endothelial cell dysfunction under diabetic condition: in vitro and in vivo study
Trimethylamine N-oxide aggravates vascular permeability and endothelial cell dysfunction under diabetic condition: in vitro and in vivo study Open
AIM: To provide the direct evidence for the crucial role of trimethylamine N-oxide (TMAO) in vascular permeability and endothelial cell dysfunction under diabetic condition. METHODS: The role of TMAO on the in vitro biological effect of hu…
View article: Global, regional, and national burdens of intraocular foreign bodies in children and adolescents from 1990 to 2019: a trend analysis
Global, regional, and national burdens of intraocular foreign bodies in children and adolescents from 1990 to 2019: a trend analysis Open
View article: Systematic review and meta-analysis of mass spectrometry proteomics applied to ocular fluids to assess potential biomarkers of age-related macular degeneration
Systematic review and meta-analysis of mass spectrometry proteomics applied to ocular fluids to assess potential biomarkers of age-related macular degeneration Open
View article: Changing Trends in the Global Burden of Cataract Over the Past 30 Years: Retrospective Data Analysis of the Global Burden of Disease Study 2019
Changing Trends in the Global Burden of Cataract Over the Past 30 Years: Retrospective Data Analysis of the Global Burden of Disease Study 2019 Open
Background Cataracts now account for the largest proportion of the global burden of blindness and vision loss. Understanding the changing trends in the global burden of cataracts over the past 30 years and the next 15 years is of clear sig…
View article: Association of Gut Microbiota with Age-Related Macular Degeneration and Glaucoma: A Bidirectional Mendelian Randomization Study
Association of Gut Microbiota with Age-Related Macular Degeneration and Glaucoma: A Bidirectional Mendelian Randomization Study Open
The objective of this study was to examine the correlation between gut microbiota and both age-related macular degeneration (AMD) and glaucoma. Mendelian randomization studies were conducted utilizing the data sourced from the genome-wide …
View article: Association of gut microbiota with age-related macular degeneration and glaucoma: a bidirectional Mendelian randomization study
Association of gut microbiota with age-related macular degeneration and glaucoma: a bidirectional Mendelian randomization study Open
Purpose The objective of this study was to eliminate any ambiguity by examining the correlation between gut microbiota and both AMD and glaucoma.
Methods Mendelian randomization studies were conducted utilizing the data sourced from the G…
View article: Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to Ocular Fluids to Assess Potential Biomarkers of Age-related Macular Degeneration
Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to Ocular Fluids to Assess Potential Biomarkers of Age-related Macular Degeneration Open
Background: Age-related macular degeneration (AMD) is a significant cause of severe vision loss. The main purpose of this study was to identify mass spectrometry proteomics-based potential biomarkers of AMD that contribute to understanding…
View article: Time trends and gender disparities of Chinese cataract burden and their predictions
Time trends and gender disparities of Chinese cataract burden and their predictions Open
AIM: To evaluate the trends and changes in the number and rates of disability-adjusted life years (DALYs) and prevalence of cataract in China between 1990 and 2019, and to predict the trends of cataract burden from 2020 to 2030. METHODS: T…
View article: Composite Hydrogel Modulates Intrinsic Immune-Cascade Neovascularization for Ocular Surface Reconstruction after Corneal Chemical Injury
Composite Hydrogel Modulates Intrinsic Immune-Cascade Neovascularization for Ocular Surface Reconstruction after Corneal Chemical Injury Open
Ocular alkali burns recruit neutrophils and triggers neutrophil extracellular trap (NET)-neovascularization cascade effects that limit ocular surface reconstruction and functional repair. However, effective inhibition of the release of neu…
View article: Efficacy and safety of ultrasound cycloplasty for the treatment of glaucoma: a Meta-analysis
Efficacy and safety of ultrasound cycloplasty for the treatment of glaucoma: a Meta-analysis Open
AIM: To evaluate the efficacy and safety of ultrasound cycloplasty (UCP) for glaucoma. METHODS: A comprehensive search of PubMed, Embase, Web of Science, and Google Scholar databases was used to select studies met the inclusion criteria. M…
View article: Subcutaneous pedicled propeller flap technique for microscopic reconstruction of eyelid defects
Subcutaneous pedicled propeller flap technique for microscopic reconstruction of eyelid defects Open
AIM: To describe the subcutaneous pedicled propeller flap technique for the microscopic reconstruction of eyelid defects and evaluate its outcomes. METHODS: The clinical data of 23 patients (23 eyes) who underwent microscopic reconstructio…
View article: Trends and disparities in disease burden of age-related macular degeneration from 1990 to 2019: Results from the global burden of disease study 2019
Trends and disparities in disease burden of age-related macular degeneration from 1990 to 2019: Results from the global burden of disease study 2019 Open
Objectives This study aims to estimate the trends and disparities in the worldwide burden for health of AMD, overall and by age, sex, socio-demographic index (SDI), region, and nation using prevalence and years lived with disability (YLDs)…
View article: Changing Trends in the Global Burden of Cataract Over the Past 30 Years: Retrospective Data Analysis of the Global Burden of Disease Study 2019 (Preprint)
Changing Trends in the Global Burden of Cataract Over the Past 30 Years: Retrospective Data Analysis of the Global Burden of Disease Study 2019 (Preprint) Open
BACKGROUND Cataracts now account for the largest proportion of the global burden of blindness and vision loss. Understanding the changing trends in the global burden of cataracts over the past 30 years and the next 15 years is of clear si…
View article: Potential relationships between uveitis and COVID-19: a bioinformatic study based on CEO database
Potential relationships between uveitis and COVID-19: a bioinformatic study based on CEO database Open
Purpose Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a great impact on human survival and a great threat to public health in countries all over the world. The link be…
View article: Comprehensive LncRNA and Potential Molecular Mechanism Analysis in Noninfectious Uveitis
Comprehensive LncRNA and Potential Molecular Mechanism Analysis in Noninfectious Uveitis Open
LncRNAs and their potential mechanisms provide new strategies for prevention and treatment for noninfectious uveitis in patients with AS, BD, and sarcoidosis.