Rong Zhang
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View article: Characterization of ocular adverse events associated with crizotinib: real-world insights from the two global pharmacovigilance databases of FAERS and VigiBase
Characterization of ocular adverse events associated with crizotinib: real-world insights from the two global pharmacovigilance databases of FAERS and VigiBase Open
To evaluate the risk of ocular adverse events (AEs) associated with crizotinib using real-world data from FAERS and VigiBase, and to characterize signal patterns through disproportionality and time-to-onset (TTO) analyses. Reports from FAE…
View article: Left Subclavian Artery Revascularization With In Situ Laser Fenestration During Thoracic Endovascular Aortic Repair for Acute Complicated or High‐Risk Type B Aortic Dissection: Results of the LLTEVAR Trial
Left Subclavian Artery Revascularization With In Situ Laser Fenestration During Thoracic Endovascular Aortic Repair for Acute Complicated or High‐Risk Type B Aortic Dissection: Results of the LLTEVAR Trial Open
Background Coverage of the left subclavian artery (LSA) during thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD) increases the risk of major adverse events (MAEs). In situ laser‐assisted fenestration allows fo…
View article: Dysfunctional cognitions and insomnia symptoms in pregnant women: the serial mediation roles of pre-sleep arousal and maladaptive habits
Dysfunctional cognitions and insomnia symptoms in pregnant women: the serial mediation roles of pre-sleep arousal and maladaptive habits Open
View article: A Functional Resting-State Network Atlas Based on 420 Older Adults with Hypertension
A Functional Resting-State Network Atlas Based on 420 Older Adults with Hypertension Open
The Risk Reduction for Alzheimer’s Disease (rrAD) trial included 513 cognitively normal, sedentary, hypertensive older adults (aged 60 to 85 years) with dementia risk factors. We utilized 420 high-quality baseline resting-state functional …
View article: Forsythoside E Alleviates Liver Injury by Targeting PKM2 Tetramerization to Promote Macrophage M2 Polarization
Forsythoside E Alleviates Liver Injury by Targeting PKM2 Tetramerization to Promote Macrophage M2 Polarization Open
Sepsis‐induced liver injury is closely associated with poor prognosis in septic patients. In this study, through integrated approaches including high‐throughput virtual screening, target fishing technology, and atomic force microscopy (AFM…
View article: Langmuir/BET ratio as a quantitative indicator: Chain length-dependent adsorption modes of fillers regulating ion transport and high-voltage performance in PEO-based composite electrolytes
Langmuir/BET ratio as a quantitative indicator: Chain length-dependent adsorption modes of fillers regulating ion transport and high-voltage performance in PEO-based composite electrolytes Open
View article: DeepSeek Outperforms GPT-4o in Multispecialty Ophthalmic Diagnosis: A Blinded Expert Evaluation of 33 Complex Cases
DeepSeek Outperforms GPT-4o in Multispecialty Ophthalmic Diagnosis: A Blinded Expert Evaluation of 33 Complex Cases Open
Purpose: To compare the diagnostic and treatment performance of DeepSeek (DS) and GPT-4o large language models (LLMs) in ophthalmology using standardized residency examination cases. Design: Cross-sectional comparative study. Participants:…
View article: Association between antibody-mediated immune responses of herpesvirus and osteoporosis: Mendelian randomization study
Association between antibody-mediated immune responses of herpesvirus and osteoporosis: Mendelian randomization study Open
Recently, several cohort studies and case-control studies have revealed an association between herpesvirus (HV) and osteoporosis (OP), while the underlying mechanisms remain unclear. The HV-triggered immune responses may be significant in …
View article: BAF60a-dependent chromatin remodeling preserves β cell function and contributes to the therapeutic benefits of GLP-1R agonists
BAF60a-dependent chromatin remodeling preserves β cell function and contributes to the therapeutic benefits of GLP-1R agonists Open
Impaired glucose-stimulated insulin secretion (GSIS) is a hallmark of β cell dysfunction in diabetes. Epigenetic mechanisms govern cellular glucose sensing and GSIS by β cells, but they remain incompletely defined. Here, we found that BAF6…
View article: Sleep quality among pregnant women: a prospective longitudinal study of trajectories and bidirectional associations with physical activity
Sleep quality among pregnant women: a prospective longitudinal study of trajectories and bidirectional associations with physical activity Open
Objectives This study aimed to investigate the trajectory patterns and influencing factors of sleep quality and verify the bidirectional association between physical activity and sleep quality during pregnancy. Design This was a prospectiv…
View article: Impact of of steaming on lipid profile of 10 sweetpotato varieties: LC-ESI-MS/MS comparative analysis
Impact of of steaming on lipid profile of 10 sweetpotato varieties: LC-ESI-MS/MS comparative analysis Open
View article: RIMA-SVG versus Ao-SVG in coronary artery bypass grafting: protocol for a prospective, randomised, double-blind, non-inferiority and single-centre trial
RIMA-SVG versus Ao-SVG in coronary artery bypass grafting: protocol for a prospective, randomised, double-blind, non-inferiority and single-centre trial Open
Introduction Coronary artery bypass grafting (CABG) is a standard treatment for coronary artery disease, particularly in patients with multivessel disease. Connecting the saphenous vein graft (SVG) to the right internal mammary artery (RIM…
View article: Ultrasound-targeted microbubble destruction: a prospective strategy for treating cardiovascular disease
Ultrasound-targeted microbubble destruction: a prospective strategy for treating cardiovascular disease Open
In China, the healthcare burden of cardiovascular diseases (CVDs) will continue to rise due to the pressure of the aging population, which has posed higher demands for CVDs prevention and treatment. Ultrasound-targeted microbubble destruct…
View article: Sleep Deprivation Aggravates Periodontitis Through Trigeminal‐Periodontal Neuroimmune Pathway Mediated by the AChE‐ACh‐α7nAChR Axis
Sleep Deprivation Aggravates Periodontitis Through Trigeminal‐Periodontal Neuroimmune Pathway Mediated by the AChE‐ACh‐α7nAChR Axis Open
Continuous sleep deprivation (SD) triggers systemic inflammatory storm and immune dysregulation, yet its specific impact on periodontitis and the corresponding therapeutic interventions remains unclear. Consequently, this study elucidates …
View article: Transcutaneous electrical acupoint stimulation: a potential bridge linking traditional Chinese medicine and AI-driven transformation in modern healthcare
Transcutaneous electrical acupoint stimulation: a potential bridge linking traditional Chinese medicine and AI-driven transformation in modern healthcare Open
View article: Analysis of clinical and genetic features in an adolescent patient with primary ciliary dyskinesia induced by homozygous mutation in the RSPH4A gene: a case report
Analysis of clinical and genetic features in an adolescent patient with primary ciliary dyskinesia induced by homozygous mutation in the RSPH4A gene: a case report Open
Primary ciliary dyskinesia (PCD) is a rare genetically heterogeneous disorder characterized by dysfunctional motile cilia, with or without detectable ultrastructural abnormalities. This study focuses on a homozygous mutation in the rare ra…
View article: Autoclave processing modulates allergenic potential of red kidney beans (Phaseolus vulgaris L.): proteomic and bioinformatics insights after in vitro gastric digestion
Autoclave processing modulates allergenic potential of red kidney beans (Phaseolus vulgaris L.): proteomic and bioinformatics insights after in vitro gastric digestion Open
View article: Distal versus conventional radial artery catheterization for hemodynamic monitoring in intensive care setting: a randomized, controlled, non-inferiority trial
Distal versus conventional radial artery catheterization for hemodynamic monitoring in intensive care setting: a randomized, controlled, non-inferiority trial Open
This study is registered in the Chinese Clinical Trials Registry (registration number: ChiCTR2400086284, registration date: 27/06/2024).
View article: A stepwise approach to designing and delivering the SCHeLTI trial community-family-mother-child obesity prevention intervention
A stepwise approach to designing and delivering the SCHeLTI trial community-family-mother-child obesity prevention intervention Open
This paper describes the methods for the development and implementation of the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI) intervention, part of a World Health Organization-supported effort to prevent childhood obesity thr…
View article: Hydrogen‐Bonding‐Guided Interfacial Water Engineering for Selective CO<sub>2</sub>‐to‐C<sub>2+</sub> Conversion at Industrial Current Densities
Hydrogen‐Bonding‐Guided Interfacial Water Engineering for Selective CO<sub>2</sub>‐to‐C<sub>2+</sub> Conversion at Industrial Current Densities Open
The electroreduction of CO 2 to multi‐carbon (C 2+ ) products offers a sustainable route for chemicals production. However, the competing hydrogen evolution reaction (HER), especially at high current densities where proton transport domina…
View article: Fatty Acid Binding Protein 4 Regulates the Antigen‐Presenting Function of Dendritic Cells Resulting in T Cell Priming in Streptozotocin‐Induced Type 1 Diabetes Mice
Fatty Acid Binding Protein 4 Regulates the Antigen‐Presenting Function of Dendritic Cells Resulting in T Cell Priming in Streptozotocin‐Induced Type 1 Diabetes Mice Open
Background Type 1 diabetes is an autoimmune disease with progressive destruction of insulin‐producing β cells in islets of Langerhans of the pancreas. However, the early pathogenic factors triggering the recruitment and activation of innat…
View article: Associations of serum elements and amino acids with autism spectrum disorder
Associations of serum elements and amino acids with autism spectrum disorder Open
Accumulating evidence suggests that serum elements and amino acids are associated with autism spectrum disorder (ASD). However, the conclusions are not exactly consistent. The objective of our study is to investigate the association of ser…
View article: Risk factors analysis and nomogram development for myelosuppression in diffuse large B-cell lymphoma patients undergoing first-line chemotherapy: a dual-centre retrospective cohort study
Risk factors analysis and nomogram development for myelosuppression in diffuse large B-cell lymphoma patients undergoing first-line chemotherapy: a dual-centre retrospective cohort study Open
Objective The primary objective of this research was to examine the characteristics of myelosuppression following first-line chemotherapy in patients suffering from diffuse large B-cell lymphoma (DLBCL). Furthermore, the study aimed to ide…
View article: Feeding probiotics-fermented distiller's grains diets increases rumen enzyme activities and glycerophospholipid levels in finishing cattle by modulating rumen microbiota
Feeding probiotics-fermented distiller's grains diets increases rumen enzyme activities and glycerophospholipid levels in finishing cattle by modulating rumen microbiota Open
These results suggest that feeding FDG diets potentially improves rumen enzyme activities and up-regulates the levels of glycerophospholipids in the rumen, which may be associated with the alterations in specific rumen microbiota involved …
View article: Impact of non-steroidal anti-inflammatory drugs exposure on persistent cough after pulmonary resection in a Chinese tertiary hospital: a prospective cohort study protocol
Impact of non-steroidal anti-inflammatory drugs exposure on persistent cough after pulmonary resection in a Chinese tertiary hospital: a prospective cohort study protocol Open
Introduction Previous studies have pointed out that persistent cough is a common complication after pulmonary resection and its occurrence is closely related to inflammatory response. However, there are no clinical studies to date that dir…
View article: Sinisan ameliorates early-life stress-induced depressive-like behaviors by repairing DRN synaptic damage through CaSR
Sinisan ameliorates early-life stress-induced depressive-like behaviors by repairing DRN synaptic damage through CaSR Open
Indroduction Early-life stress (ELS) is a well-established risk factor for adolescent depression, yet the underlying neurobiological mechanisms remain incompletely understood. The dorsal raphe nucleus (DRN), a key serotonergic center, demo…
View article: Charting Brain Growth in Chinese Children with Autism
Charting Brain Growth in Chinese Children with Autism Open
Autism Spectrum Disorder (ASD) is a lifelong neurodevelopmental condition characterized by atypical brain growth. While advances in neuroimaging and openly sharing large-sample datasets such as the Autism Brain Imaging Data Exchange (ABIDE…
View article: An improved technique to treat persistent extensive Descemet’s membrane detachment following cataract surgery: a case report
An improved technique to treat persistent extensive Descemet’s membrane detachment following cataract surgery: a case report Open
View article: [Change of plasma level of valine and its relationship with developmental quotient in children with autism].
[Change of plasma level of valine and its relationship with developmental quotient in children with autism]. Open
The level of valine in plasma of autistic children is relatively lower, and there is a certain relationship between plasma valine level and the fine movement and personal/social function among children with autism.
View article: Deubiquitinating enzyme USP2 regulates brown adipose tissue thermogenesis via controlling EBF2 stabilization
Deubiquitinating enzyme USP2 regulates brown adipose tissue thermogenesis via controlling EBF2 stabilization Open
Our data demonstrated the vital role of USP2 in regulating BAT activation and systemic energy homeostasis. Activation of USP2-EBF2 interaction could be a potential therapeutic strategy against obesity.