Rongbin Zheng
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View article: Table S2 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S2 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Beta score (sheet1), mapping ratio (sheet2), and essential genes list (sheet3) of CRISPR screens.
View article: Table S7 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S7 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Cox regression model of IFNG expression on patients’ survival in TCGA and Available expression data of ICB treatment.
View article: Table S3 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S3 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Genes’ average Δβ-scores across all cancer cell lines (sheet1); Gene sets enrichment for positively (sheet2) / negatively (sheet3) selected genes in CRISPR screen. GSEA was used to perform the enrichment analysis; sgRNA sequences of AAVS1,…
View article: Table S6 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S6 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Expression of DSB repair genes especially resistant or non-resistant DSB repair genes in TCGA datasets with SSB repair genes mutation and deletion.
View article: Dosage-sensitive <i>RBFOX2</i> autoregulation promotes cardiomyocyte differentiation by maturing the transcriptome
Dosage-sensitive <i>RBFOX2</i> autoregulation promotes cardiomyocyte differentiation by maturing the transcriptome Open
SUMMARY Haploinsufficiency of the RNA splicing regulator, RBFOX2 , is linked to congenital heart disease (CHD), yet its pathogenic mechanisms remain unclear. Here, we demonstrate that RBFOX2 is essential for progressing cardiomyocyte (CM) …
View article: Transcription factor 4 maintains endothelial cell identity by inhibiting endothelial to mesenchymal transition
Transcription factor 4 maintains endothelial cell identity by inhibiting endothelial to mesenchymal transition Open
Endothelial to mesenchymal transition (EndoMT) is essential for embryonic heart development and contributes to many pathological processes. It is unclear how the balance between endothelial cell (EC) identity and EndoMT mediators is regula…
View article: Human single-cell atlas analysis reveals heterogeneous endothelial signaling
Human single-cell atlas analysis reveals heterogeneous endothelial signaling Open
Endothelial cells (ECs) play complex roles across tissues and vessel types. Yet, systematic investigations of EC heterogeneity in the combined context of vessel type and tissue microenvironment are still largely lacking. We integrated over…
View article: A genetically engineered vertebrate animal model of <i>NAA15</i>-related heart disease uncovers myocardial growth, contractility, and mitochondrial defects
A genetically engineered vertebrate animal model of <i>NAA15</i>-related heart disease uncovers myocardial growth, contractility, and mitochondrial defects Open
Delineating the genetic and environmental instigators of congenital heart disease (CHD), affecting up to 1% of newborns, will improve preventative, diagnostic, and therapeutic efforts to mitigate the disease. Although mutations in the N-al…
View article: MEBOCOST maps metabolite-mediated intercellular communications using single-cell RNA-seq
MEBOCOST maps metabolite-mediated intercellular communications using single-cell RNA-seq Open
Cell-cell communication (CCC) is crucial for cellular function and tissue homeostasis. Existing methods for protein-oriented CCC detection often overlook metabolite-mediated CCC (mCCC), and adapting them to mCCC analysis is challenging due…
View article: Supplementary Data from Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer
Supplementary Data from Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer Open
Supplementary Data include: 1, Supplementary Methods: a detailed description of data processing, computational analysis, and web interface functions; 2, Supplementary References; 3, Supplementary Figures 1-6: Fig. S1: Cancer sample reclust…
View article: Supplementary Data from Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer
Supplementary Data from Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer Open
Supplementary Data include: 1, Supplementary Methods: a detailed description of data processing, computational analysis, and web interface functions; 2, Supplementary References; 3, Supplementary Figures 1-6: Fig. S1: Cancer sample reclust…
View article: Supplementary Video S1 from Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer
Supplementary Video S1 from Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer Open
Cistrome Cancer overview.
View article: Supplementary Video S1 from Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer
Supplementary Video S1 from Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer Open
Cistrome Cancer overview.
View article: 505 IGSF8 is a novel innate immune checkpoint and cancer immunotherapy target
505 IGSF8 is a novel innate immune checkpoint and cancer immunotherapy target Open
Background Loss of MHC-I antigen presentation is often associated with T-cell excluded tumors, and represents a common mechanism of both primary and acquired resistance to immune checkpoint blockade (ICB) treatment. MHC-I normally acts as …
View article: Comprehensive analysis of intercellular communication in the thermogenic adipose niche
Comprehensive analysis of intercellular communication in the thermogenic adipose niche Open
View article: Publisher Correction: Epigenetic landscape reveals MECOM as an endothelial lineage regulator
Publisher Correction: Epigenetic landscape reveals MECOM as an endothelial lineage regulator Open
View article: Epigenetic landscape reveals MECOM as an endothelial lineage regulator
Epigenetic landscape reveals MECOM as an endothelial lineage regulator Open
View article: Table S6 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S6 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Expression of DSB repair genes especially resistant or non-resistant DSB repair genes in TCGA datasets with SSB repair genes mutation and deletion.
View article: Table S3 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S3 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Genes’ average Δβ-scores across all cancer cell lines (sheet1); Gene sets enrichment for positively (sheet2) / negatively (sheet3) selected genes in CRISPR screen. GSEA was used to perform the enrichment analysis; sgRNA sequences of AAVS1,…
View article: Table S1 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S1 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
IFN-γ sensitivity of cancer cells (n = 43) from CCLE (sheet1); Gene sets enrichment for highly expressed gene sets in IFN-γ resistant/sensitive cell lines using CCLE transcriptomic dataset (sheet2-3).
View article: Table S7 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S7 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Cox regression model of IFNG expression on patients’ survival in TCGA and Available expression data of ICB treatment.
View article: Table S4 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S4 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Raw count table for RNA-seq.
View article: Table S2 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S2 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Beta score (sheet1), mapping ratio (sheet2), and essential genes list (sheet3) of CRISPR screens.
View article: Table S5 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S5 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Single-strand break repair genes (sheet1), double-strand break repair genes (sheet2), and DNA methylation related genes (sheet3).
View article: Table S5 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S5 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Single-strand break repair genes (sheet1), double-strand break repair genes (sheet2), and DNA methylation related genes (sheet3).
View article: Data from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Data from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
The pleiotropic cytokine interferon-gamma (IFNγ) is associated with cytostatic, antiproliferation, and proapoptotic functions in cancer cells. However, resistance to IFNγ occurs in many cancer cells, and the underlying mechanism is not ful…
View article: Supplementary Figures from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Supplementary Figures from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Supplementary Figures S1-S8
View article: Table S4 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S4 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Raw count table for RNA-seq.
View article: Table S1 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S1 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
IFN-γ sensitivity of cancer cells (n = 43) from CCLE (sheet1); Gene sets enrichment for highly expressed gene sets in IFN-γ resistant/sensitive cell lines using CCLE transcriptomic dataset (sheet2-3).
View article: Table S3 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
Table S3 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open
Genes’ average Δβ-scores across all cancer cell lines (sheet1); Gene sets enrichment for positively (sheet2) / negatively (sheet3) selected genes in CRISPR screen. GSEA was used to perform the enrichment analysis; sgRNA sequences of AAVS1,…