Explanipedia

Early detection of urological tumors based on genomic characteristics of cell-free DNA fragments: a multi-center study Open

Huiyong Zhang, Chunmeng Wei, Rongbin Zhou, Wenhao Lu, Xiao Li , et al. · 2025

Cell-free DNA (cfDNA) has shown potential in distinguishing cancer patients from healthy individuals. This study investigates cfDNA fragmentomics-fragmentation patterns, end motifs (EDMs), and breakpoint motifs (BPMs)-to develop an early d…

SPP1 as a biomarker for idiopathic membranous nephropathy progression and its regulatory role in inflammation and fibrosis Open

Shuting Pang, Rongbin Zhou, Zige Liu, Boji Xie, Fugang Liu , et al. · 2025

Objective Idiopathic membranous nephropathy (IMN) is a leading cause of nephrotic syndrome in middle-aged and elderly populations. Early intervention can delay disease progression and improve patient outcomes. This study aims to identify u…

Hemoglobin-associated CALR in proximal tubule cells can be used as a biomarker for idiopathic membranous nephropathy Open

Shuting Pang, Qi Tan, Boji Xie, Bingmei Feng, Rongbin Zhou , et al. · 2025

Objective Idiopathic membranous nephropathy (IMN) is the leading cause of nephrotic syndrome in adults. Given the limited diagnostic options currently available, we performed RNA sequencing (RNA-seq) of urinary cells to identify potential …

A small molecule directly targets NLRP3 to promote inflammasome activation and antitumor immunity Open

Xumei Liu, Hongbin He, Ming‐Hui Qi, Zhongjun Jiang, Bolong Lin , et al. · 2025

Immune checkpoint blockade (ICB) therapies have emerged as promising treatment of cancer, but the efficacy is limited. NLRP3 inflammasome activation in tumor microenvironment can promote the infiltration of cytotoxic lymphocytes and antitu…

ZBP1 Senses Splicing Aberration through Z-RNA to promote Cell Death Open

Zhang-Hua Yang, Zhiyu Cai, Puqi Wu, Bo-Xin Zhang, Cun Yang , et al. · 2025

RNA splicing, a highly regulated process performed by the spliceosome, is crucial for eukaryotic gene expression and cellular function. Numerous cellular stresses including oncogenic insults dysregulate RNA splicing, often provoking inflam…

Single-cell transcriptomic analysis reveals CD8 + T cell heterogeneity and identifies a prognostic signature in cervical cancer Open

Rongbin Zhou, Yuli Xie, Zuheng Wang, Zige Liu, Wenhao Lu , et al. · 2025

NLRP3 inflammasome in neuroinflammation and central nervous system diseases Open

Wen Xu, Yi Huang, Rongbin Zhou · 2025

Neuroinflammation plays an important role in the pathogenesis of various central nervous system (CNS) diseases. The NLRP3 inflammasome is an important intracellular multiprotein complex composed of the innate immune receptor NLRP3, the ada…

Identification of blood-derived exosomal tumor RNA signatures as noninvasive diagnostic biomarkers for multi-cancer: a multi-phase, multi-center study Open

Fubo Wang, Chengbang Wang, Shaohua Chen, Chunmeng Wei, Jin Ji , et al. · 2025

Author Correction: GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunit Open

Jiaxian Yan, Chi Zhang, Yueli Xu, Zonghui Huang, Qingyuan Ye , et al. · 2024

Disulfidptosis-related genes serve as potential prognostic biomarkers and indicate tumor microenvironment characteristics and immunotherapy response in prostate cancer Open

Rongbin Zhou, Dingjin Lu, Junhao Mi, Chengbang Wang, Wenhao Lu , et al. · 2024

A novel measurement method for SiPM external crosstalk probability at low temperature Open

Guanda Li, Lei Wang, Xilei Sun, Fang Liu, Cong Guo , et al. · 2024

Silicon photomultipliers (SiPMs) are being considered as potential replacements for conventional photomultiplier tubes (PMTs). However, a significant disadvantage of SiPMs is crosstalk (CT), wherein photons propagate through other pixels, …

DAMPs and DAMP-sensing receptors in inflammation and diseases Open

Ming Ma, Wei Jiang, Rongbin Zhou · 2024

Cryo-EM structures of human GPR34 enable the identification of selective antagonists Open

Anjie Xia, Xihao Yong, Changbin Zhang, Guifeng Lin, Guowen Jia , et al. · 2023

GPR34 is a functional G-protein-coupled receptor of Lysophosphatidylserine (LysoPS), and has pathogenic roles in numerous diseases, yet remains poorly targeted. We herein report a cryo-electron microscopy (cryo-EM) structure of GPR34 bound…

Apilimod activates the NLRP3 inflammasome through lysosome-mediated mitochondrial damage Open

Yingting Hou, Hongbin He, Ming Ma, Rongbin Zhou · 2023

NLRP3 is an important innate immune sensor that responses to various signals and forms the inflammasome complex, leading to IL-1β secretion and pyroptosis. Lysosomal damage has been implicated in NLRP3 inflammasome activation in response t…

A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis Open

Hongdi Ma, Taidou Hu, Wanyin Tao, Jiyu Tong, Zili Han , et al. · 2023

Inflammatory bowel diseases (IBD) are known to have complex, genetically influenced etiologies, involving dysfunctional interactions between the intestinal immune system and the microbiome. Here, we characterized how the RNA transcript fro…

Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways Open

Shiyu Bai, Qielan Wu, Shasha Zhu, Yuwei Zhang, Xuran Chen , et al. · 2023

Activation of mTORC1 is essential for anti-tumor function of iNKT cells. The mechanisms underlying impaired mTORC1 activation in intratumoral iNKT cells remain unclear. Via generating Vam6 +/- mice and using flow cytometry, image approach,…

Hypothalamic–pituitary–bone marrow axis promotes tumor-induced immunosuppression Open

Yueli Xu, Jiaxian Yan, Rongbin Zhou · 2022

Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues Open

Jingbo Qie, Yang Liu, Yunzhi Wang, Fan Zhang, Zhaoyu Qin , et al. · 2022

Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation Open

Chen Chen, Weiqiao Zhang, Tingyue Zhou, Qiuyuan Liu, Chao Han , et al. · 2022

Metabolic rewiring is essential for Th17 cells' functional identity to sense and interpret environmental cues. However, the environmental metabolic checkpoints with specific regulation of Th17 cells, manifesting potential therapeutic oppor…

Promoting Cardiac Repair through Simple Engineering of Nanoparticles with Exclusive Targeting Capability toward Myocardial Reperfusion Injury by Thermal Resistant Microfluidic Platform (Adv. Funct. Mater. 36/2022) Open

Zehua Liu, Wenhua Lian, Qiang Long, Ruoyu Cheng, Giulia Torrieri , et al. · 2022

Cardiac Repair In article number 2204666, Qiang Zhao, Xiaofeng Ye, Xianming Deng, Hélder A. Santos, and co-workers introduce a microfluidics-assisted single step, green synthesis method for producing targeting ligands free heart homing nan…

Vam6 upregulated by lactic acid inhibits anti-tumor effects of intratumoral iNKT cells via modulating AMPK/mTOR pathways Open

Huimin Zhang, Shiyu Bai, Qielan Wu, Shasha Zhu, Yuwei Zhang , et al. · 2022

Activation of mTORC1 is essential for anti-tumor function of iNKT cells. The mechanisms underlying impaired mTORC1 activation in intratumoral iNKT cells remain unclear. Here, we showed that lactic acid from tumor cells increased Vam6 expre…

Promoting Cardiac Repair through Simple Engineering of Nanoparticles with Exclusive Targeting Capability toward Myocardial Reperfusion Injury by Thermal Resistant Microfluidic Platform Open

Zehua Liu, Wenhua Lian, Qiang Long, Ruoyu Cheng, Giulia Torrieri , et al. · 2022

Nanoparticle (NP)‐based intravenous administration represents the most convenient cardiac targeting delivery routine, yet, there are still therapeutic issues due to the lack of targeting efficiency and specificity. Active targeting methods…

Editorial: Patho- and Physiological Roles of Inflammasomes Open

Guangxun Meng, Carsten J. Kirschning, Rongbin Zhou · 2022

EDITORIAL article Front. Immunol., 28 February 2022Sec. Inflammation Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.857929

An RRx-001 Analogue With Potent Anti-NLRP3 Inflammasome Activity but Without High-Energy Nitro Functional Groups Open

Hualong Lin, Mingyang Yang, Cong Li, Bolong Lin, Xianming Deng , et al. · 2022

NLRP3 inflammasome is involved in the pathology of multiple human inflammatory diseases but there are still no clinically available medications targeting the NLRP3 inflammasome. We have previously identified RRx-001 as a highly selective a…

Inhibition of the NLRP3 Inflammasome Activation by Manoalide Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis Open

Cong Li, Hualong Lin, Hongbin He, Ming Ma, Wei Jiang , et al. · 2022

The activation of NLRP3 inflammasome leads to cell pyroptosis and inflammatory cytokines secretion and gets involved in the development of many diseases, such as neuroinflammation and metabolic syndrome, but the drugs targeting NLRP3 are n…

Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma Open

Ming Ma, Guo‐Yang Li, Ming‐Hui Qi, Wei Jiang, Rongbin Zhou · 2021

Inhaled allergens promote inflammatory response, tissue damage, and airway hyperresponsiveness in the lungs, leading to allergic asthma. NLRP3, as an immune sensor of infections and cellular stress, is associated with the development and e…

ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation Open

Shuhang Li, Linlin Wang, Zhihao Xu, Yuanyuan Huang, Rufeng Xue , et al. · 2021

Activation of NLRP3 inflammasome is precisely controlled to avoid excessive activation. Although multiple molecules regulating NLRP3 inflammasome activation have been revealed, the checkpoints governing NLRP3 inflammasome activation remain…

NLRP3 inflammasome activation and cell death Open

Yi Huang, Wen Xu, Rongbin Zhou · 2021

GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair Open

Xiaqiong Wang, Juan Cai, Bolong Lin, Ming Ma, Ye Tao , et al. · 2021

RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor Open

Yun Chen, Hongbin He, Bolong Lin, Yun Chen, Xianming Deng , et al. · 2021

Rongbin Zhou YOU? Author Swipe