Rongcan Luo
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View article: The Protective Mechanism of ApoE3 R136S in Alzheimer’s Disease: A New Hope for Neurodegeneration
The Protective Mechanism of ApoE3 R136S in Alzheimer’s Disease: A New Hope for Neurodegeneration Open
View article: Next questions of autophagy in neurodegenerative diseases: From mechanisms to therapeutics
Next questions of autophagy in neurodegenerative diseases: From mechanisms to therapeutics Open
View article: A microengineered 3D human neurovascular unit model to probe the neuropathogenesis of herpes simplex encephalitis
A microengineered 3D human neurovascular unit model to probe the neuropathogenesis of herpes simplex encephalitis Open
Herpes simplex encephalitis (HSE) caused by HSV-1 is the most common non-epidemic viral encephalitis, and the neuropathogenesis of HSE remains elusive. This work describes a 3D human neurovascular unit (NVU) model that allows to explore th…
View article: Macrocyclic Diterpenoids from Euphorbia peplus Possessing Activity Towards Autophagic Flux
Macrocyclic Diterpenoids from Euphorbia peplus Possessing Activity Towards Autophagic Flux Open
Euphjatrophanes H–L (1–5), four new jatrophane-type and one new lathyrane-type diterpenoid, were isolated from Euphorbia peplus, along with eight known diterpenoids (6–13). Their structures were established on the basis of extensive spectr…
View article: Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway
Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway Open
View article: New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217)
New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217) Open
Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A–C (1–3), were isolated from the seeds of Tabernaemontana crassa. Tabercrassine A (1) is an ibogan–ibogan-type bisindole alkaloid which is formed by the polym…
View article: Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology
Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology Open
Ten jatrophane diterpenoids were isolated from the whole plant Euphorbia peplus Linn. including seven new ones, named euphjatrophanes A-G (labeled compounds 1, 2, 4–8). Their structures were elucidated with a combination of spectroscopic a…
View article: The Innovation Life: An international journal of life sciences
The Innovation Life: An international journal of life sciences Open
View article: CCDC 2098350: Experimental Crystal Structure Determination
CCDC 2098350: Experimental Crystal Structure Determination Open
View article: Ganoapplins a and B with an Unprecedented 6/6/6/5/6-Fused Pentacyclic Skeleton from <i>Ganoderma</i> Inhibit Tau Pathology Through Activating Autophagy
Ganoapplins a and B with an Unprecedented 6/6/6/5/6-Fused Pentacyclic Skeleton from <i>Ganoderma</i> Inhibit Tau Pathology Through Activating Autophagy Open
View article: Doublecortin-Expressing Neurons in Chinese Tree Shrew Forebrain Exhibit Mixed Rodent and Primate-Like Topographic Characteristics
Doublecortin-Expressing Neurons in Chinese Tree Shrew Forebrain Exhibit Mixed Rodent and Primate-Like Topographic Characteristics Open
Doublecortin (DCX) is transiently expressed in new-born neurons in the subventricular zone (SVZ) and subgranular zone (SGZ) related to adult neurogenesis in the olfactory bulb (OB) and hippocampal formation. DCX immunoreactive (DCX+) immat…
View article: A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline
A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline Open
View article: Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation
Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation Open
Morphine is frequently used for pain relief, but long-term morphine therapy in patients with chronic pain results in analgesic tolerance and hyperalgesia. There are no effective therapeutic treatments that limit these detrimental side effe…
View article: The anatomy of the skin of the Chinese tree shrew is very similar to that of human skin
The anatomy of the skin of the Chinese tree shrew is very similar to that of human skin Open
The Chinese tree shrew (Tupaia belangeri chinensis) is a small mammal closely related to primates. It has a small body size, low maintenance cost, and a relatively short reproductive cycle, all of which has made it the ideal model f…
View article: A positive feedback self-regulatory loop between miR-210 and HIF-1α mediated by CPEB2 is involved in trophoblast syncytiolization: implication of trophoblast malfunction in preeclampsia
A positive feedback self-regulatory loop between miR-210 and HIF-1α mediated by CPEB2 is involved in trophoblast syncytiolization: implication of trophoblast malfunction in preeclampsia Open
The pregnancy complication preeclampsia is directly associated with hypoxic stress and insufficient trophoblast cell differentiation. The hypoxia-inducible microRNA (miRNA), miR-210, has been identified as a significantly up-regulated miRN…
View article: Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model
Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model Open
Alzheimer disease (AD) is the most common neurodegenerative disease. An imbalance between the production and clearance of Aβ (amyloid beta) is considered to be actively involved in AD pathogenesis. Macroautophagy/autophagy is a major cellu…
View article: <i>Complement C7</i>is a novel risk gene for Alzheimer's disease in Han Chinese
<i>Complement C7</i>is a novel risk gene for Alzheimer's disease in Han Chinese Open
Alzheimer's disease is the most common neurodegenerative disease, and has a high level of genetic heritability and population heterogeneity. In this study, we performed the whole-exome sequencing of Han Chinese patients with familial and/o…
View article: <i>Atg5</i>- and <i>Atg7</i>-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine
<i>Atg5</i>- and <i>Atg7</i>-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine Open
The molecular basis of chronic morphine exposure remains unknown. In this study, we hypothesized that macroautophagy/autophagy of dopaminergic neurons would mediate the alterations of neuronal dendritic morphology and behavioral responses …
View article: Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A
Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A Open
Preeclampsia, a relatively common pregnancy disorder, is a major contributor to maternal mortality and morbidity worldwide. An elevation in microRNA-210 (miR-210) expression in the placenta has been reported to be associated with preeclamp…
View article: Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation
Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation Open
Autophagy is involved in the pathogenesis of neurodegenerative diseases including Parkinson disease (PD). However, little is known about the regulation of autophagy in neurodegenerative process. In this study, we characterized aberrant act…