Rongguang Zhang
YOU?
Author Swipe
View article: A systematic review and meta-analysis of the immunogenicity and safety of Chikungunya vaccine
A systematic review and meta-analysis of the immunogenicity and safety of Chikungunya vaccine Open
Background Since July 2025, there have been outbreaks of chikungunya fever in some parts of China, which has drawn widespread social attention. Vaccination is the most economical and effective means of preventing and controlling infectious…
View article: Chikungunya fever outbreak: Addressing globle public health challenge through One Health approaches
Chikungunya fever outbreak: Addressing globle public health challenge through One Health approaches Open
Since 2004, chikungunya fever (CHIKF), a neglected tropical disease, has emerged as a growing public health concern, with outbreaks reported in over 119 countries across Asia, Africa, the Americas, Europe, and Oceania. Currently, there is …
View article: Evaluation and analysis of theoretical knowledge proficiency and practical skills among parasitic disease practitioners in Hainan province: a cross-sectional survey
Evaluation and analysis of theoretical knowledge proficiency and practical skills among parasitic disease practitioners in Hainan province: a cross-sectional survey Open
Objective This study aimed to evaluate both theoretical knowledge proficiency and practical skills among practitioners specializing in parasitic diseases in Hainan province, providing essential groundwork for ongoing capacity enhancement e…
View article: <i>RPF2</i> regulates the protein kinase B/mammalian target of rapamycin pathway in the pathogenesis of <i>Helicobacter pylori</i>
<i>RPF2</i> regulates the protein kinase B/mammalian target of rapamycin pathway in the pathogenesis of <i>Helicobacter pylori</i> Open
BACKGROUND RPF2 is a crucial factor in ribosome synthesis, which has been linked to the development of several cancers. However, the mechanism of RPF2 in gastric carcinogenesis is unclear. AIM To explore the role and mechanism of RPF2 in t…
View article: Impact of SARS-CoV-2 Variant NSP6 on Pathogenicity: Genetic Analysis and Cell Biology
Impact of SARS-CoV-2 Variant NSP6 on Pathogenicity: Genetic Analysis and Cell Biology Open
SARS-CoV-2 nonstructural protein (NSP) 6 is one of the factors affecting viral pathogenicity. Mutations in NSP6 continuously emerge during viral transmission and are closely associated with alterations in viral pathogenicity. This study in…
View article: Strategies for cultivating public health professionals to address biosafety challenges of Hainan Free Trade Port
Strategies for cultivating public health professionals to address biosafety challenges of Hainan Free Trade Port Open
Efficient prevention and control of biosafety risks is a critical guarantee for implementing the Hainan Free Trade Port construction strategy, and also the primary task for Hainan public health development. The unique natural environment, …
View article: Characterization and Effect of Non-Structural Protein 6 (Nsp6) Gene Mutation of Sars-Cov-2 Variants
Characterization and Effect of Non-Structural Protein 6 (Nsp6) Gene Mutation of Sars-Cov-2 Variants Open
View article: Regulation of cagA- <i>Helicobacter</i> on gastric PIM2 expression in gastric cancer
Regulation of cagA- <i>Helicobacter</i> on gastric PIM2 expression in gastric cancer Open
BACKGROUND: The association between infection with cagA -positive H. pylori and an elevated susceptibility to gastric cancer has been firmly established. PIM2 is known to be overexpressed in various types of cancers; however, the specific …
View article: Herb–Nanoparticle Hybrid System for Improved Oral Delivery Efficiency to Alleviate Breast Cancer Lung Metastasis
Herb–Nanoparticle Hybrid System for Improved Oral Delivery Efficiency to Alleviate Breast Cancer Lung Metastasis Open
HNS provides an appealing system with multi-component binding of herbal medicine to facilitate both oral nanoparticle delivery efficiency and the alleviation of lung metastasis. This strategy may potentially help improve treatment for pati…
View article: Incorporating the Results of Geological Disaster Ecological Risk Assessment into Spatial Policies for Ecological Functional Areas: Practice in the Qilian Mountains of China
Incorporating the Results of Geological Disaster Ecological Risk Assessment into Spatial Policies for Ecological Functional Areas: Practice in the Qilian Mountains of China Open
Geological hazards cause changes in the quality of the ecological environment, affect the function and stability of ecosystems, and negatively impact the maintenance and restoration of ecological functions in ecological functional areas (E…
View article: Nonlinear empirical failure criterion for rocks under triaxial compression
Nonlinear empirical failure criterion for rocks under triaxial compression Open
Based on existing triaxial compression experimental data, a new empirical failure criterion with wide applicability was proposed considering hydrostatic pressure, second stress invariance, and maximum shear stress. Four fitting evaluation …
View article: Microbial community, pathogenic bacteria and high-risk anti-biotic resistance genes at two tropical coastal beaches adjacent to villages in Hainan, China
Microbial community, pathogenic bacteria and high-risk anti-biotic resistance genes at two tropical coastal beaches adjacent to villages in Hainan, China Open
The low microbial community diversity, however, did not indicate a reduced risk. The transfer of high-risk ARGs to extreme coastal environments should be given sufficient attention.
View article: Association between living habits, indoor humidity, ventilation and asthma among residents in the tropical regions of China
Association between living habits, indoor humidity, ventilation and asthma among residents in the tropical regions of China Open
Objective Asthma is a major public health problem that affects both children and adults, and its prevalence varies among people with different climatic characteristics and living habits. However, few studies have investigated the prevalenc…
View article: The association of sickle cell disorder with adverse outcomes in COVID‐19 patients: A meta‐analysis
The association of sickle cell disorder with adverse outcomes in COVID‐19 patients: A meta‐analysis Open
The aim is to elucidate the relationship between sickle cell disorder and severe COVID‐19. We systematically searched the required articles in three electronic databases, extracting and pooling effect sizes (ES) and 95% confidence interval…
View article: Oral membrane-biomimetic nanoparticles for enhanced endocytosis and regulation of tumor-associated macrophage
Oral membrane-biomimetic nanoparticles for enhanced endocytosis and regulation of tumor-associated macrophage Open
View article: Regulation of CagA-Helicobacter on Gastric PIM2 Expression in Gastric Cancer
Regulation of CagA-Helicobacter on Gastric PIM2 Expression in Gastric Cancer Open
Infection with cagA-positive H. pylor i has been linked to an increased risk of gastric cancer. However, the precise mechanism by which cagA regulates PIM2 expression in gastric cancer is currently unknown. To address this issue, a mutant …
View article: Supplementary Figure 1 from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
Supplementary Figure 1 from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues Open
Supplementary Figure 1 from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
View article: Data from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
Data from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues Open
5,10-Methenyltetrahydrofolate synthetase (MTHFS) regulates the flow of carbon through the one-carbon metabolic network, which supplies essential components for the growth and proliferation of cells. Inhibition of MTHFS in human MCF-7 breas…
View article: Supplementary Figure Legend from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
Supplementary Figure Legend from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues Open
Supplementary Figure Legend from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
View article: Supplementary Table 1 from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
Supplementary Table 1 from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues Open
Supplementary Table 1 from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
View article: Supplementary Figure Legend from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
Supplementary Figure Legend from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues Open
Supplementary Figure Legend from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
View article: Supplementary Figure 1 from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
Supplementary Figure 1 from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues Open
Supplementary Figure 1 from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
View article: Supplementary Table 1 from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
Supplementary Table 1 from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues Open
Supplementary Table 1 from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
View article: Data from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues
Data from Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues Open
5,10-Methenyltetrahydrofolate synthetase (MTHFS) regulates the flow of carbon through the one-carbon metabolic network, which supplies essential components for the growth and proliferation of cells. Inhibition of MTHFS in human MCF-7 breas…
View article: Crystals, molecular complexes, and methods of developing lead compounds for inhibitors of bacterial IMPDH
Crystals, molecular complexes, and methods of developing lead compounds for inhibitors of bacterial IMPDH Open
The present invention relates to a data storage medium encoded with the structural coordinates of crystallized molecules and molecular complexes which comprise the active site binding pockets of bacterial IMPDH. Such data storage material …
View article: Vitamin D deficiency in dengue fever patients' coinfected with H. pylori in Pakistan. A case-control study
Vitamin D deficiency in dengue fever patients' coinfected with H. pylori in Pakistan. A case-control study Open
Introduction Dengue fever is a vector-borne disease with an estimate of 390 million persons getting the infection each year with a significant public health impact. It has been reported DENV patients with vitamin D deficiency led to severe…
View article: Differential Expression of α-Enolase in Clinical Gastric Tissues and Cultured Normal/Cancer Cells in Response to Helicobacter pylori Infection and cagA Transfection
Differential Expression of α-Enolase in Clinical Gastric Tissues and Cultured Normal/Cancer Cells in Response to Helicobacter pylori Infection and cagA Transfection Open
Background and Objectives: The role of α-enolase (ENO1) in Helicobacter pylori-related gastric lesions might be a critical factor in the pathogenesis, but remains undefined. Materials and Methods: This study investigated the differential e…
View article: Application of CRISPR/Cas Systems in the Nucleic Acid Detection of Infectious Diseases
Application of CRISPR/Cas Systems in the Nucleic Acid Detection of Infectious Diseases Open
The CRISPR/Cas system is a protective adaptive immune system against attacks from foreign mobile genetic elements. Since the discovery of the excellent target-specific sequence recognition ability of the CRISPR/Cas system, the CRISPR/Cas s…
View article: The CRISPR-Cas system as a tool for diagnosing and treating infectious diseases
The CRISPR-Cas system as a tool for diagnosing and treating infectious diseases Open
View article: Risk Score Prediction Model of Prognosis in GC Patients by Age and Gender Combined With m6A Modification Genes FTO and RBM15
Risk Score Prediction Model of Prognosis in GC Patients by Age and Gender Combined With m6A Modification Genes FTO and RBM15 Open
Background: Gastric cancer (GC) has a high mortality rate. N6-methyladenosine (m6A) is involved in the development of GC. Age and gender are associated with GC incidence and survival. This study aimed to explore the risk score prediction m…