Ronghai Cheng
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View article: Acoustic ejection mass spectrometry: An integrated pipeline for ultra-high throughput screening, reactivity profiling, and potency analysis of covalent BTK inhibitors
Acoustic ejection mass spectrometry: An integrated pipeline for ultra-high throughput screening, reactivity profiling, and potency analysis of covalent BTK inhibitors Open
Covalent drug discovery has garnered renewed interest due to its potential to target proteins previously considered "undruggable." Intact protein mass spectrometry (MS) is a critical technique for providing direct evidence of covalent drug…
View article: An <i>S</i>=1 Iron(IV) Intermediate Revealed in a Non‐Heme Iron Enzyme‐Catalyzed Oxidative C−S Bond Formation
An <i>S</i>=1 Iron(IV) Intermediate Revealed in a Non‐Heme Iron Enzyme‐Catalyzed Oxidative C−S Bond Formation Open
Ergothioneine (ESH) and ovothiol A (OSHA) are two natural thiol‐histidine derivatives. ESH has been implicated as a longevity vitamin and OSHA inhibits the proliferation of hepatocarcinoma. The key biosynthetic step of ESH and OSHA in the …
View article: An <i>S</i>=1 Iron(IV) Intermediate Revealed in a Non‐Heme Iron Enzyme‐Catalyzed Oxidative C−S Bond Formation
An <i>S</i>=1 Iron(IV) Intermediate Revealed in a Non‐Heme Iron Enzyme‐Catalyzed Oxidative C−S Bond Formation Open
Ergothioneine (ESH) and ovothiol A (OSHA) are two natural thiol‐histidine derivatives. ESH has been implicated as a longevity vitamin and OSHA inhibits the proliferation of hepatocarcinoma. The key biosynthetic step of ESH and OSHA in the …
View article: Correspondence on “Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1”
Correspondence on “Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1” Open
In their recent Angewandte Chemie publication (doi: 10.1002/anie.202112063), Cen, Wang, Zhou et al. reported the crystal structure of a ternary complex of the non‐heme iron endoperoxidase FtmOx1 (PDB entry 7ETK). The biochemical data asses…
View article: Correspondence on “Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1”
Correspondence on “Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1” Open
In their recent Angewandte Chemie publication (doi: 10.1002/anie.202112063), Cen, Wang, Zhou et al. reported the crystal structure of a ternary complex of the non‐heme iron endoperoxidase FtmOx1 (PDB entry 7ETK). The biochemical data asses…
View article: Light-Driven Oxidative Demethylation Reaction Catalyzed by a Rieske-Type Non-heme Iron Enzyme Stc2
Light-Driven Oxidative Demethylation Reaction Catalyzed by a Rieske-Type Non-heme Iron Enzyme Stc2 Open
Rieske-type non-heme iron oxygenases/oxidases catalyze a wide range of transformations. Their applications in bioremediation or biocatalysis face two key barriers: the need of expensive NAD(P)H as a reductant and a proper reductase to medi…
View article: Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues
Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues Open
FtmOx1 is a nonheme iron (NHFe) endoperoxidase, catalyzing three disparate reactions, endoperoxidation, alcohol dehydrogenation, and dealkylation, under in vitro conditions; the diversity complicates its mechanistic studies. In this study,…
View article: OvoA<sub>Mtht</sub>from<i>Methyloversatilis thermotolerans</i>ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities
OvoA<sub>Mtht</sub>from<i>Methyloversatilis thermotolerans</i>ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities Open
Modulation of OvoA Mtht 's dual activities: sulfoxide synthase and thiol oxygenase.
View article: Plasmonic photoreactors-coated plastic tubing as combined-active-and-passive antimicrobial flow sterilizer
Plasmonic photoreactors-coated plastic tubing as combined-active-and-passive antimicrobial flow sterilizer Open
Plasmonic photoreactor nanocomposite coating provides both active and passive antibacterial properties to plastic surfaces.
View article: Implications for an Imidazole-2-yl Carbene Intermediate in the Rhodanase-Catalyzed C–S Bond Formation Reaction of Anaerobic Ergothioneine Biosynthesis
Implications for an Imidazole-2-yl Carbene Intermediate in the Rhodanase-Catalyzed C–S Bond Formation Reaction of Anaerobic Ergothioneine Biosynthesis Open
In the anaerobic ergothioneine biosynthetic pathway, a rhodanese domain containing enzyme (EanB) activates tne hercynine's sp2 ε-C-H Dona ana replaces it with a C-S bond to produce ergothioneine. The key intermediate for this trans-sulfura…
View article: Single-Step Replacement of an Unreactive C–H Bond by a C–S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis
Single-Step Replacement of an Unreactive C–H Bond by a C–S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis Open
Ergothioneine, a natural longevity vitamin and antioxidant, is a thiol-histidine derivative. Recently, two types of biosynthetic pathways were reported. In the aerobic ergothioneine biosynthesis, a non-heme iron enzyme incorporates a sulfo…
View article: Crystal Structure of the Ergothioneine Sulfoxide Synthase from <i>Candidatus Chloracidobacterium thermophilum</i> and Structure-Guided Engineering To Modulate Its Substrate Selectivity.
Crystal Structure of the Ergothioneine Sulfoxide Synthase from <i>Candidatus Chloracidobacterium thermophilum</i> and Structure-Guided Engineering To Modulate Its Substrate Selectivity. Open
Ergothioneine is a thiohistidine derivative with potential benefits on many aging-related diseases. The central step of aerobic ergothioneine biosynthesis is the oxidative C-S bond formation reaction catalyzed by mononuclear nonheme iron s…
View article: Crystal Structure of the Ergothioneine Sulfoxide Synthase from <i>Candidatus Chloracidobacterium thermophilum</i> and Structure-Guided Engineering To Modulate Its Substrate Selectivity
Crystal Structure of the Ergothioneine Sulfoxide Synthase from <i>Candidatus Chloracidobacterium thermophilum</i> and Structure-Guided Engineering To Modulate Its Substrate Selectivity Open
Ergothioneine is a thiohistidine derivative with potential benefits on many aging-related diseases. The central step of aerobic ergothioneine biosynthesis is the oxidative C–S bond formation reaction catalyzed by mononuclear nonheme iron s…
View article: Virtual Pharmacist: A Platform for Pharmacogenomics
Virtual Pharmacist: A Platform for Pharmacogenomics Open
We present Virtual Pharmacist, a web-based platform that takes common types of high-throughput data, namely microarray SNP genotyping data, FASTQ and Variant Call Format (VCF) files as inputs, and reports potential drug responses in terms …