Ronghua ZhuGe
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View article: Chelerythrine Chloride Alleviated Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Glycolytic Pathway Through Targeting Glyceraldehyde-3-Phosphate Dehydrogenase
Chelerythrine Chloride Alleviated Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Glycolytic Pathway Through Targeting Glyceraldehyde-3-Phosphate Dehydrogenase Open
Acute lung injury (ALI) is a fatal respiratory disease caused by excessive inflammation. Chelerythrine chloride (CH), an isoquinoline alkaloid, exhibits diverse biological activities. The research focused on assessing CH’s therapeutic effe…
View article: Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3
Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3 Open
Periodontitis is a chronic periodontal inflammatory disease caused by periodontal pathogens commonly seen in adults. Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a …
View article: Small-molecule targeting BCAT1-mediated BCAA metabolism inhibits the activation of SHOC2-RAS-ERK to induce apoptosis of Triple-negative breast cancer cells
Small-molecule targeting BCAT1-mediated BCAA metabolism inhibits the activation of SHOC2-RAS-ERK to induce apoptosis of Triple-negative breast cancer cells Open
Collectively, this study not only elucidates the oncogenic role of BCAT1 and its downstream SHOC2-RAS-ERK signaling axis in TNBC progression but also opens up avenues for potential therapies targeting BCAT1 or BCAA metabolism (using EB alo…
View article: TMEM16A in smooth muscle cells acts as a pacemaker channel in the internal anal sphincter
TMEM16A in smooth muscle cells acts as a pacemaker channel in the internal anal sphincter Open
View article: Phenanthroline relaxes uterine contractions induced by diverse contractile agents by decreasing cytosolic calcium concentration
Phenanthroline relaxes uterine contractions induced by diverse contractile agents by decreasing cytosolic calcium concentration Open
View article: Bitter taste receptors in the reproductive system: Function and therapeutic implications
Bitter taste receptors in the reproductive system: Function and therapeutic implications Open
Type 2 taste receptors (TAS2Rs), traditionally known for their role in bitter taste perception, are present in diverse reproductive tissues of both sexes. This review explores our current understanding of TAS2R functions with a particular …
View article: Mode Switch of Ca2 + Oscillation-Mediated Uterine Peristalsis and Associated Embryo Implantation Impairments in Mouse Adenomyosis
Mode Switch of Ca2 + Oscillation-Mediated Uterine Peristalsis and Associated Embryo Implantation Impairments in Mouse Adenomyosis Open
Adenomyosis is a debilitating gynecological disease of the uterus with no medicinal cure. The tissue injury and repair hypothesis for adenomyosis suggests that uterine hyperperistalsis or dysperistalsis plays a pivotal role in establishing…
View article: Genetic deletion of the <i>Tas2r143</i>/<i>Tas2r135</i>/<i>Tas2r126</i> cluster reveals that TAS2Rs may not mediate bitter tastant‐induced bronchodilation
Genetic deletion of the <i>Tas2r143</i>/<i>Tas2r135</i>/<i>Tas2r126</i> cluster reveals that TAS2Rs may not mediate bitter tastant‐induced bronchodilation Open
Bitter taste receptors (TAS2Rs) and their signaling elements are detected throughout the body, and bitter tastants induce a wide variety of biological responses in tissues and organs outside the mouth. However, the roles of TAS2Rs in these…
View article: Editorial: Extra-Oral Taste Receptors: Function, Disease and Evolution
Editorial: Extra-Oral Taste Receptors: Function, Disease and Evolution Open
EDITORIAL article Front. Physiol., 30 October 2020 | https://doi.org/10.3389/fphys.2020.607134
View article: OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism
OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism Open
Significance Identifying cell-surface receptors required for viral infection is important for developing antiviral therapies and effective vaccines. Human cytomegalovirus (HCMV) infects epithelial cells during interhost transmission. The p…
View article: Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor–transmembrane protein 16A–voltage-dependent Ca2+ channel axis and contribute to bronchial hyperresponsiveness in asthma
Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor–transmembrane protein 16A–voltage-dependent Ca2+ channel axis and contribute to bronchial hyperresponsiveness in asthma Open
View article: Bitter taste receptors as targets for tocolytics in preterm labor therapy
Bitter taste receptors as targets for tocolytics in preterm labor therapy Open
Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity, with few prevention and treatment options. Uterine contraction is a central feature of PTB, so gaining new insights into the mechanisms of this contraction and c…
View article: Extraoral bitter taste receptors in health and disease
Extraoral bitter taste receptors in health and disease Open
Bitter taste receptors (TAS2Rs or T2Rs) belong to the superfamily of seven-transmembrane G protein–coupled receptors, which are the targets of >50% of drugs currently on the market. Canonically, T2Rs are located in taste buds of the ton…
View article: The molecular basis of the genesis of basal tone in internal anal sphincter
The molecular basis of the genesis of basal tone in internal anal sphincter Open