Rongjun He
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View article: A Novel Class of Complement 3a Receptor Agonists and Antagonists Derived from the TLQP-21 Peptide
A Novel Class of Complement 3a Receptor Agonists and Antagonists Derived from the TLQP-21 Peptide Open
The complement 3a receptor (C3aR) is a G-protein-coupled receptor (GPCR) involved in inflammatory, metabolic, and neurological diseases. Two endogenous ligands (C3a and TLQP-21) and small molecules (SB290157 and JR14a) differentially signa…
View article: Protective mechanism of quercetin nanoliposomes on hydrogen peroxide-induced oxidative damage in 3D Caco-2 cell model
Protective mechanism of quercetin nanoliposomes on hydrogen peroxide-induced oxidative damage in 3D Caco-2 cell model Open
Quercetin is a flavonol that is widely distributed in plants. Although quercetin has good antioxidant activity, the exact mechanism is still unclear in intestinal cell model. In this study, a 3D Caco-2 cell model was constructed. An oxidat…
View article: Synergistic Antitumor Effect of Grifola frondose Polysaccharide—Protein Complex in Combination with Cyclophosphamide in H22 Tumor-Bearing Mice
Synergistic Antitumor Effect of Grifola frondose Polysaccharide—Protein Complex in Combination with Cyclophosphamide in H22 Tumor-Bearing Mice Open
Hepatocellular carcinoma (HCC) is the most common type of liver malignancy and remains a global health threat. The objective of the current study was to determine whether the combination of a cold-water extracted polysaccharide-protein com…
View article: The Interaction between Mushroom Polysaccharides and Gut Microbiota and Their Effect on Human Health: A Review
The Interaction between Mushroom Polysaccharides and Gut Microbiota and Their Effect on Human Health: A Review Open
Mushroom polysaccharides are a kind of biological macromolecule extracted from the fruiting body, mycelium or fermentation liquid of edible fungi. In recent years, the research on mushroom polysaccharides for alleviating metabolic diseases…
View article: Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors
Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors Open
Protein tyrosine phosphatases constitute an important class of drug targets whose potential has been limited by the paucity of drug-like small-molecule inhibitors. We recently described a class of active-site-directed, moderately selective…
View article: The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors
The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors Open
View article: A Facile Procedure for One-Pot Stable Conjugation of Two Proglucagon Cysteine-Containing Peptide Analogs
A Facile Procedure for One-Pot Stable Conjugation of Two Proglucagon Cysteine-Containing Peptide Analogs Open
Optimization of peptides for therapeutic purposes often includes chemical conjugation or modification with substituents that serve to broaden pharmacology or improve pharmacokinetics. We report a convenient and rapid procedure for one-pot,…
View article: Preparation and Evaluation of Microcapsules Encapsulating Royal Jelly Sieve Residue: Flavor and Release Profile
Preparation and Evaluation of Microcapsules Encapsulating Royal Jelly Sieve Residue: Flavor and Release Profile Open
This study aimed to improve the flavor of royal jelly residue via microencapsulation technology using Arabic gum and gelatin as wall materials. This microencapsulation technology showed a good encapsulation yield of 85.71 ± 2.84% and encap…
View article: CB1 and GLP-1 Receptors Cross Talk Provides New Therapies for Obesity
CB1 and GLP-1 Receptors Cross Talk Provides New Therapies for Obesity Open
Glucagon-like peptide 1 receptor (GLP-1R) agonists effectively improve glycemia and body weight in patients with type 2 diabetes and obesity but have limited weight-lowering efficacy and minimal insulin sensitizing action. In preclinical m…
View article: Mechanochemical-Assisted Extraction and Pharmacological Study of Triterpenoids from Antrodia Camphorata
Mechanochemical-Assisted Extraction and Pharmacological Study of Triterpenoids from Antrodia Camphorata Open
Antrodia camphorata (AC) is a precious medicinal mushroom native to Taiwan and famous for its excellent pharmacological activity. A ball mill assisted mechanochemical extraction method was applied in the extraction of triterpenoids from An…
View article: Clearance kinetics of the VGF-derived neuropeptide TLQP-21
Clearance kinetics of the VGF-derived neuropeptide TLQP-21 Open
View article: Genome-wide analysis of ATP-binding cassette (ABC) transporters in the sweetpotato whitefly, Bemisia tabaci
Genome-wide analysis of ATP-binding cassette (ABC) transporters in the sweetpotato whitefly, Bemisia tabaci Open
View article: Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism
Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism Open
The low molecular weight protein tyrosine phosphatase (LMW-PTP) is a regulator of a number of signaling pathways and has been implicated as a potential target for oncology and diabetes/obesity. There is significant therapeutic interest in …
View article: Tissue-specific Proteogenomic Analysis of Plutella xylostella Larval Midgut Using a Multialgorithm Pipeline
Tissue-specific Proteogenomic Analysis of Plutella xylostella Larval Midgut Using a Multialgorithm Pipeline Open
View article: Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from <i>Mycobacterium tuberculosis</i>
Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from <i>Mycobacterium tuberculosis</i> Open
mPTPB is a virulent phosphatase from Mycobacterium tuberculosis and a promising therapeutic target for tuberculosis. To facilitate mPTPB-based drug discovery, we identified α-sulfophenylacetic amide (SPAA) from cefsulodin, a third generati…
View article: Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors
Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors Open
Protein tyrosine phosphatases (PTPs) are potential therapeutic targets for many diseases. Unfortunately, despite considerable drug discovery efforts devoted to PTPs, obtaining selective and cell permeable PTP inhibitors remains highly chal…