Rongjun Wan
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View article: Epithelial AhR Suppresses Allergen-Induced Oxidative Stress and Senescence via c-Myc Regulation
Epithelial AhR Suppresses Allergen-Induced Oxidative Stress and Senescence via c-Myc Regulation Open
Environmental allergens trigger epithelial reactive oxygen species (ROS) production and cellular senescence, contributing to airway inflammation. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor responsive to en…
View article: Interaction between macrophages and ferroptosis: Metabolism, function, and diseases
Interaction between macrophages and ferroptosis: Metabolism, function, and diseases Open
Ferroptosis, an iron-dependent programmed cell death process driven by reactive oxygen species-mediated lipid peroxidation, is regulated by several metabolic processes, including iron metabolism, lipid metabolism, and redox system. Macroph…
View article: Correction for: Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-κB pathway and secrete chemokines
Correction for: Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-κB pathway and secrete chemokines Open
The authors found that in Figure 3B the HE staining image intended for the TAK-242 group was inadvertently replaced with one from the DNase group in Figure 2B, leading to a duplication.They also found duplications in Figure 3J, where IHC i…
View article: PPARγ attenuates cellular senescence of alveolar macrophages in asthma-COPD overlap
PPARγ attenuates cellular senescence of alveolar macrophages in asthma-COPD overlap Open
Background Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents a complex condition characterized by shared clinical and pathophysiological features of asthma and COPD in older individuals. However, the pathophysiol…
View article: PPARγ Attenuates Cellular Senescence of Alveolar Macrophages in Asthma- COPD Overlap
PPARγ Attenuates Cellular Senescence of Alveolar Macrophages in Asthma- COPD Overlap Open
Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents a complex condition characterized by shared clinical and pathophysiological features of asthma and COPD in older individuals. However, the pathophysiology of ACO …
View article: Aryl hydrocarbon receptor: Linking environment to aging process in elderly patients with asthma
Aryl hydrocarbon receptor: Linking environment to aging process in elderly patients with asthma Open
Aging is a significant risk factor for various diseases, including asthma, and it often leads to poorer clinical outcomes, particularly in elderly individuals. It is recognized that age-related diseases are due to a time-dependent accumula…
View article: Solute Carrier Family 26 Member 4 (SLC26A4), A Potential Therapeutic Target for Asthma
Solute Carrier Family 26 Member 4 (SLC26A4), A Potential Therapeutic Target for Asthma Open
Asthma is a prevalent respiratory condition with multifaceted pathomechanisms, presenting challenges for therapeutic development. The SLC (Solute Carrier) gene family, encompassing diverse membrane transport proteins, plays pivotal roles i…
View article: Effective delivery of miR-511-3p with mannose-decorated exosomes with RNA nanoparticles confers protection against asthma
Effective delivery of miR-511-3p with mannose-decorated exosomes with RNA nanoparticles confers protection against asthma Open
Our previous studies have shown that miR-511-3p treatment has a beneficial effect in alleviating allergic airway inflammation. Here, we sought to explore its therapeutic potential in animal models and gain a deeper understanding of its the…
View article: Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages
Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages Open
Background Obesity-related asthma is a kind of nonallergic asthma with excessive neutrophil infiltration in the airways. However, the underlying mechanisms have been poorly elucidated. Among the adipokines related to obesity, leptin is rel…
View article: Cellular senescence in asthma: from pathogenesis to therapeutic challenges
Cellular senescence in asthma: from pathogenesis to therapeutic challenges Open
Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the population worldwide. While cellular senescence is a normal physiological process, the accumulation of senescent cells is considered a trigger that transf…
View article: Association of oily fish and nonoily fish intakes with all-cause mortality and cause-specific mortality: a large population-based prospective study
Association of oily fish and nonoily fish intakes with all-cause mortality and cause-specific mortality: a large population-based prospective study Open
View article: Transformation of chronic disease management: Before and after the COVID-19 outbreak
Transformation of chronic disease management: Before and after the COVID-19 outbreak Open
Adults with chronic diseases often experience a decline in their quality of life along with frequent exacerbations. These diseases can cause anxiety and impose a significant economic burden. Self-management is a crucial aspect of treatment…
View article: Association of milk consumption with all-cause mortality and cardiovascular outcomes: a UK Biobank based large population cohort study
Association of milk consumption with all-cause mortality and cardiovascular outcomes: a UK Biobank based large population cohort study Open
View article: Vanadium exposure exacerbates allergic airway inflammation and remodeling through triggering reactive oxidative stress
Vanadium exposure exacerbates allergic airway inflammation and remodeling through triggering reactive oxidative stress Open
Background Metal components of environmental PM2.5 are associated with the exacerbation of allergic diseases like asthma. In our recent hospital-based population study, exposure to vanadium is shown to pose a significant risk for current a…
View article: Vanadium exposure exacerbates allergic airway inflammation and remodeling through triggering reactive oxidative stress
Vanadium exposure exacerbates allergic airway inflammation and remodeling through triggering reactive oxidative stress Open
Background Metal components of environmental PM2.5 are associated with the exacerbation of allergic diseases like asthma. In our recent hospital-based population study, exposure to vanadium is shown to pose a significant risk for current a…
View article: Quercetin alleviates ferroptosis accompanied by reducing M1 macrophage polarization during neutrophilic airway inflammation
Quercetin alleviates ferroptosis accompanied by reducing M1 macrophage polarization during neutrophilic airway inflammation Open
Ferroptosis is a kind of regulated cell death, supporting the pathological process of lung inflammation, including asthma. Quercetin (QCT), a kind of natural dietary flavonoid, exerts anti-inflammatory and anti-ferroptosis effects in vario…
View article: Association between glucosamine use and cancer mortality: A large prospective cohort study
Association between glucosamine use and cancer mortality: A large prospective cohort study Open
Objective Previous studies have shown anti-cancer and anti-inflammatory benefits of glucosamine. This study was performed to prospectively evaluate the association between glucosamine supplementation and the mortality of multiple cancers b…
View article: CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway
CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway Open
Cell migration inducing protein (CEMIP) has been linked to carcinogenesis in several types of cancers. However, the role and mechanism of CEMIP in osteosarcoma remain unclear. This study investigated the role of CEMIP in the progression an…
View article: Type II alveolar epithelial cell aryl hydrocarbon receptor protects against allergic airway inflammation through controlling cell autophagy
Type II alveolar epithelial cell aryl hydrocarbon receptor protects against allergic airway inflammation through controlling cell autophagy Open
Rationale Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, has been considered as an important regulator for immune diseases. We have previously shown that AhR protects against allergic airway inflammation. The und…
View article: Exposure to second-hand smoke is an independent risk factor of small airway dysfunction in non-smokers with chronic cough: A retrospective case-control study
Exposure to second-hand smoke is an independent risk factor of small airway dysfunction in non-smokers with chronic cough: A retrospective case-control study Open
Objectives This study aimed to identify the potential risk factors for small airway dysfunction (SAD) in non-smokers with chronic cough. Methods Non-smokers with chronic cough who underwent lung function tests at Xiangya Hospital from May …
View article: Gene Expression Microarray Data Identify Hub Genes Involved in Osteoarthritis
Gene Expression Microarray Data Identify Hub Genes Involved in Osteoarthritis Open
The present study was performed to explore the underlying molecular mechanisms and screen hub genes of osteoarthritis (OA) via bioinformatics analysis. In total, twenty-five OA synovial tissue samples and 25 normal synovial tissue samples …
View article: Profilin 1 Induces Tumor Metastasis by Promoting Microvesicle Secretion Through the ROCK 1/p-MLC Pathway in Non-Small Cell Lung Cancer
Profilin 1 Induces Tumor Metastasis by Promoting Microvesicle Secretion Through the ROCK 1/p-MLC Pathway in Non-Small Cell Lung Cancer Open
Profilin 1 (PFN1), an actin-binding protein, plays contrasting roles in the metastasis of several cancers; however, its role in non-small cell lung cancer (NSCLC) metastasis remains unclear. Here, PFN1 expression was upregulated in metasta…
View article: A Clinically Applicable Nomogram for Predicting the Risk of Invasive Mechanical Ventilation in Pneumocystis jirovecii Pneumonia
A Clinically Applicable Nomogram for Predicting the Risk of Invasive Mechanical Ventilation in Pneumocystis jirovecii Pneumonia Open
Objective Pneumocystis jirovecii pneumonia (PCP) is a life-threatening disease associated with a high mortality rate among immunocompromised patient populations. Invasive mechanical ventilation (IMV) is a crucial component of treatment for…
View article: Quercetin relieves ferroptosis and M1 polarization in neutrophilic asthmatic mouse model
Quercetin relieves ferroptosis and M1 polarization in neutrophilic asthmatic mouse model Open
Background Ferroptosis is a kind of regulated cell death, widely involved in lung diseases, including asthma. Macrophages are vital regulators in ferroptosis, and ferroptosis could promote M1 macrophage polarization. Quercetin (QCT), a kin…
View article: Identification of tumour immune infiltration-associated snoRNAs (TIIsno) for predicting prognosis and immune landscape in patients with colon cancer via a TIIsno score model
Identification of tumour immune infiltration-associated snoRNAs (TIIsno) for predicting prognosis and immune landscape in patients with colon cancer via a TIIsno score model Open
National Key R & D Program of China, National Natural Science Foundation of China, key projects from the Nature Science Foundation of Hunan Province, projects from Beijing CSCO Clinical Oncology Research Foundation, Fundamental Research Fu…
View article: Association of Milk Consumption With All-Cause Mortality And Cardiovascular Outcomes: A Large Population-Based Cohort Study
Association of Milk Consumption With All-Cause Mortality And Cardiovascular Outcomes: A Large Population-Based Cohort Study Open
View article: Transcriptome Sequencing Analysis of lncRNA and mRNA Expression Profiles in Bone Nonunion
Transcriptome Sequencing Analysis of lncRNA and mRNA Expression Profiles in Bone Nonunion Open
Background . Bone nonunion is a serious complication of fracture. This study explored the differentially expressed lncRNAs (DELs) and mRNAs (DEGs) and identified potential lncRNA‐mRNA interactions in bone nonunion. Methods . We extracted t…
View article: Association of Oily and Nonoily Fish Intake with All Cause and Cause Specific Mortality: A Large Population-Based Prospective Study
Association of Oily and Nonoily Fish Intake with All Cause and Cause Specific Mortality: A Large Population-Based Prospective Study Open
View article: Association of Never Eating Sugar or Foods/Drinks Containing Sugar with Risks of All-Cause Mortality and Cardiovascular Disease Outcomes: A Prospective Cohort Study
Association of Never Eating Sugar or Foods/Drinks Containing Sugar with Risks of All-Cause Mortality and Cardiovascular Disease Outcomes: A Prospective Cohort Study Open
View article: The Predictive Values of Advanced Non-Small Cell Lung Cancer Patients Harboring Uncommon EGFR Mutations—The Mutation Patterns, Use of Different Generations of EGFR-TKIs, and Concurrent Genetic Alterations
The Predictive Values of Advanced Non-Small Cell Lung Cancer Patients Harboring Uncommon EGFR Mutations—The Mutation Patterns, Use of Different Generations of EGFR-TKIs, and Concurrent Genetic Alterations Open
Introduction Epidermal growth factor receptor ( EGFR ) 19del and L858R mutation are known as “common mutations” in non-small cell lung cancer (NSCLC) and predict sensitivities to EGFR tyrosine kinase inhibitors (TKIs), whereas 20ins and T7…