Rongtao Xue
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View article: The synergistic effect of c-Myb hyperactivation and Pu.1 deficiency induces Pelger–Huët anomaly and promotes sAML
The synergistic effect of c-Myb hyperactivation and Pu.1 deficiency induces Pelger–Huët anomaly and promotes sAML Open
Approximately 30% of patients with myelodysplastic syndrome (MDS) progress to secondary acute myeloid leukemia (sAML) via accumulating gene mutations. Genomic analyses reveal a complex interplay among mutant genes, with co-occurring and mu…
View article: [Early cellular immune exhaustion in patients with Epstein-Barr virus activation following haploidentical hematopoietic stem cell transplantation].
[Early cellular immune exhaustion in patients with Epstein-Barr virus activation following haploidentical hematopoietic stem cell transplantation]. Open
Objective: This study aimed to investigate the association between early immune reconstitution and Epstein-Barr virus (EBV) reactivation by analyzing changes in natural killer (NK), B, and T cells and their functional status in the periphe…
View article: Ebf1 Is Involved in Primitive Myelopoiesis and Contributes in Leukemia Pathogenesis
Ebf1 Is Involved in Primitive Myelopoiesis and Contributes in Leukemia Pathogenesis Open
Acute myeloid leukemia (AML) is caused by the abnormal proliferation and differentiation of a clonal population of myeloid progenitors. EBF1 is a key transcriptional factor in regulating hematopoiesis and has been linked to acute lymphobla…
View article: Mesenchymal stromal cells ameliorate chronic GVHD by boosting thymic regeneration in a CCR9-dependent manner in mice
Mesenchymal stromal cells ameliorate chronic GVHD by boosting thymic regeneration in a CCR9-dependent manner in mice Open
Chronic graft-versus-host disease (cGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Mature donor T cells within the graft contribute to severe damage of thymic epithelial cells (T…
View article: Cytokines induced memory-like NK cells engineered to express CD19 CAR exhibit enhanced responses against B cell malignancies
Cytokines induced memory-like NK cells engineered to express CD19 CAR exhibit enhanced responses against B cell malignancies Open
CD19 chimeric antigen receptor (CAR) engineered NK cells have been used for treating patients with relapsed and/or refractory B cell malignancies and show encouraging outcomes and safety profile. However, the poor persistence of NK cells r…
View article: Csf1rb regulates definitive hematopoiesis in zebrafish
Csf1rb regulates definitive hematopoiesis in zebrafish Open
In vertebrates, hematopoietic stem and progenitor cells (HSPCs) are capable of self-renewal and continuously replenishing all mature blood lineages throughout life. However, the molecular signaling regulating the maintenance and expansion …
View article: Functional Verification of Novel ELMO1 Variants by Live Imaging in Zebrafish
Functional Verification of Novel ELMO1 Variants by Live Imaging in Zebrafish Open
ELMO1 (Engulfment and Cell Motility1) is a gene involved in regulating cell motility through the ELMO1-DOCK2-RAC complex. Contrary to DOCK2 (Dedicator of Cytokinesis 2) deficiency, which has been reported to be associated with immunodefici…