Explanipedia

Preliminary exploration of programmed death 1 inhibitor combined with fruquintinib and docetaxel for advanced colorectal cancer Open

Xiang‐Gao Meng, Cai Yu-mei, Ning‐Ning Sun, Wen‐Hua Zhang, Ruixue Cui , et al. · 2025

BACKGROUND Immune checkpoint inhibitors have demonstrated significant efficacy in colorectal cancer (CRC) patients with microsatellite instability-high or deficient mismatch repair. However, their efficacy as monotherapy is limited in micr…

Comparative Study on Multimodal Imaging Applications in Dementia with Lewy Bodies: From Imaging Features to Clinical Practice Implications Open

Menglin Liang, Chenhao Jia, Ruixue Cui · 2025

Objective: To explore the value of multimodal molecular imaging in diagnosing and differentiating dementia with Lewy bodies (DLB). Methods: A retrospective analysis was conducted on clinical data and multimodal molecular imaging of 40 prob…

Synergistic Chem-Biological Strategy for Enhanced Degradation of Low-Density Polyethylene Open

Ruixue Cui, Caili Dai, Chunyan Zhou, Biao Gong, Kai Liu , et al. · 2025

Structures of African swine fever virus topoisomerase complex and their implications Open

Jie Yang, Zhiwei Shao, Xin Zhao, Weizhen Zhang, Yixi Zhang , et al. · 2024

A novel MAPT variant (E342K) as a cause of familial progressive supranuclear palsy Open

Hang Li, Qijun Li, Qin Weng, Ruixue Cui, Tzu‐Chen Yen , et al. · 2024

Background MAPT variants are a known cause of frontotemporal dementia and Parkinsonian syndrome, of which progressive supranuclear palsy syndrome (PSP) is a rare manifestation. Objective To report a novel MAPT variant in a PSP pedigree wit…

Feasibility of <sup>18</sup>F‐florzolotau Quantification in Patients with Alzheimer’s Disease Based on an MRI‐free Tau PET Template Open

Jiaying Lu, Zizhao Ju, Min Wang, Xun Sun, Chenhao Jia , et al. · 2023

Background Quantification of tau accumulation using positron emission tomography (PET) is critical for the diagnosis of Alzheimer’s disease (AD). This study aimed to evaluate the feasibility of 18 F‐florzolotau quantification in patients w…

CSD 2249576: Experimental Crystal Structure Determination Open

Lei Li, Yan Zhao, Jun‐Jie Wang, Ruixue Cui, Yanyan Li , et al. · 2023

An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely availabl…

Endometrial clear cell carcinoma with non-gestational choriocarcinoma differentiation: use of rapamycin maintenance Open

Zhibo Zhang, Zichen Zhao, Jing Wang, Ruixue Cui, Fengzhi Feng · 2023

CCDC 2033229: Experimental Crystal Structure Determination Open

Ruixue Cui, Wei Sun, Meiying Liu, Jing Shi, Zhiliang Liu · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Correction: Characterizing Rosai-Dorfman disease with [18F]FDG PET/CT: a retrospective analysis of a single-center study Open

Jianan Zhang, Ruixue Cui, Li J, Xinxin Cao, Yaping Luo · 2023

The Brain Aging National Cohort-PUMC: study design and baseline characteristics Open

Fei Han, Wenying Qiu, Lixin Zhou, Jun Ni, Yao Ming , et al. · 2023

Objectives: To describe the study design and baseline characteristics of the Brain Aging National Cohort (BANC)-Peking Union Medical College (PUMC), a study aiming to identify risk and protective factors that contribute to brain aging and …

Analysis of positron emission tomography hypometabolic patterns and neuropsychiatric symptoms in patients with dementia syndromes Open

Jinghuan Gan, Zhihong Shi, Chuantao Zuo, Xiaobin Zhao, Shuai Liu , et al. · 2023

Aims To estimate the proportions of specific hypometabolic patterns and their association with neuropsychiatric symptoms (NPS) in patients with cognitive impairment (CI). Methods This multicenter study with 1037 consecutive patients was co…

A deep learning model based on the attention mechanism for automatic segmentation of abdominal muscle and fat for body composition assessment Open

Hao Shen, He Pin, Ren Ya, Zhengyong Huang, Shuluan Li , et al. · 2023

This work demonstrates a method for the automatic outlining of subcutaneous fat, skeletal muscle, and visceral fat areas at L3.

Deep learning for predicting epidermal growth factor receptor mutations of non-small cell lung cancer on PET/CT images Open

Zhenghui Xiao, Haihua Cai, Yue Wang, Ruixue Cui, Li Huo , et al. · 2023

Combined with experiments, the demonstrated PET/CT fusion algorithm outperformed radiomics methods in predicting EGFR and non-EGFR mutations in NSCLC.

Phase separation of SGS3 drives siRNA body formation and promotes endogenous gene silencing Open

Huijuan Tan, Wentao Luo, Wei Yan, Jie Liu, Yalikunjiang Aizezi , et al. · 2023

The generation of small interfering RNA (siRNA) involves many RNA processing components, including SUPPRESSOR OF GENE SILENCING 3 (SGS3), RNA-DEPENDENT RNA POLYMERASE 6 (RDR6), and DICER-LIKE proteins (DCLs). Nonetheless, how these compone…

Neurological disorders associated with glutamic acid decarboxylase 65 antibodies: Clinical spectrum and prognosis of a cohort from China Open

Lin Bai, Haitao Ren, Menglin Liang, Qiang Lü, Nan Lin , et al. · 2022

Objective To describe clinical phenotypes and prognosis of neurological autoimmunity related to glutamic acid decarboxylase 65 (GAD65) antibodies in China. Method In this retrospective observational study from Peking Union Medical College …

Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1 Open

Ruixue Cui, Hao Li, Jin Zhao, Xuhang Li, Jianhua Gan , et al. · 2022

Neurospora crassa protein QDE-1, a member of the two-barrel polymerase superfamily, possesses both DNA- and RNA-dependent RNA polymerase (DdRP and RdRP) activities. The dual activities are essential for the production of double-stranded RN…

The characteristics of glucose metabolism and functional connectivity in posterior default network during nondemented aging: relationship with executive function performance Open

Kai Xu, Na Niu, Xin Li, Yuan Chen, Dandan Wang , et al. · 2022

Background Understanding the characteristics of intrinsic connectivity networks (ICNs) in terms of both glucose metabolism and functional connectivity (FC) is important for revealing cognitive aging and neurodegeneration, but the relations…

Concurrent chemoradiotherapy using gemcitabine and nedaplatin in recurrent or locally advanced head and neck squamous cell carcinoma Open

Ruixue Huo, Yingying Jin, Yong-Xue Zhuo, Xiaotong Ji, Yu Cui , et al. · 2022

Gemcitabine plus nedaplatin with concurrent chemoradiotherapy is a therapeutic option for HNSCC with predictable tolerability. Considering the high adverse event rate, the optimized dose and schedule must be further explored.

Doping Ruthenium into Metal Matrix for Promoted pH‐Universal Hydrogen Evolution Open

Jiqing Jiao, Nannan Zhang, Chao Zhang, Ning Sun, Yuan Pan , et al. · 2022

For heterogeneous catalysts, the active sites exposed on the surface have been investigated intensively, yet the effect of the subsurface‐underlying atoms is much less scrutinized. Here, a surface‐engineering strategy to dope Ru into the s…

Phase Separation of SGS3 Drives siRNA Body Formation and Promotes Endogenous Gene Silencing Open

Huijuan Tan, Wentao Luo, Wei Yan, Jie Liu, Yalikunjiang Aizezi , et al. · 2022

A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia Open

Shifu Xiao, Piu Chan, Tao Wang, Zhen Hong, Shuzhen Wang , et al. · 2021

Correction to: 68Ga-FAPI outperforms 18F-FDG PET/CT in identifying solitary fibrous tumor Open

Rongxi Wang, Qingxing Liu, Huimin Sui, Mu Zhang, Zhaohui Zhu , et al. · 2021

Relationship between the disrupted topological efficiency of the structural brain connectome and glucose hypometabolism in normal aging Open

Qiuhui Bi, Wenxiao Wang, Na Niu, He Li, Yezhou Wang , et al. · 2020

A 36-week Multicenter, Randomised, Double-blind, Placebo-controlled, Parallel-group, Phase 3 Clinical Trial of Sodium Oligomannate for Mild-to-Moderate Alzheimer's Dementia Open

Shifu Xiao, Piu Chan, Tao Wang, Zhen Hong, Shuzhen Wang , et al. · 2020

Background: New therapies are urgently needed for Alzheimer’s disease (AD). Sodium oligomannate (GV-971) is a marine-derived oligosaccharide which reconstitutes gut microbiota, reduces neuroinflammation, decreases amyloid deposition, and i…

Synergism of cisplatin-oleanolic acid co-loaded hybrid nanoparticles on gastric carcinoma cells for enhanced apoptosis and reversed multidrug resistance Open

Danyang Li, Ruixue Cui, Shuning Xu, Ying Liu · 2020

Combined administration of different drugs is a widely acknowledged approach for effective cancer therapy. However, the limited targeting, as well as inferior drug loading capacities of current drug delivery systems (DDS), are still the bo…

CCDC 1578487: Experimental Crystal Structure Determination Open

Ruixue Cui, Yongyan Wan, Guanfeng Ji, Zhiliang Liu · 2019

Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues Open

Yiqing Chen, Hehua Liu, Chun Yang, Yanqing Gao, Xiang Yu , et al. · 2019

Controlled synthesis of MOFs@MOFs core–shell structure for photodynamic therapy and magnetic resonance imaging Open

Xuechuan Gao, Guanfeng Ji, Ruixue Cui, Zhiliang Liu · 2018

For the first time, this work designs and constructs a fascinating [email protected] core–shell structure, in which the inner Prussian blue (PB) can be used to magnetic resonance imaging and the outer Ti-MIL-125 can serve as photosensitive…

Beijing Aging Brain Rejuvenation Initiative: aging with grace Open

Yanping Wang, Kewei Chen, Caishui Yang, Wang Fang, X. B. Wang , et al. · 2018

With the aging of the population, diseases related to cognitive impairment have caused great harm to society and families. Objective evaluation of the level of cognitive aging and clarification of the process and neural mechanism of cognit…

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