Rongzhang He
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View article: Regulatory T and CXCR3+ Circulating Tfh Cells Concordantly Shape the Neutralizing Antibody Responses in Individuals Who Have Recovered from Mild COVID-19
Regulatory T and CXCR3+ Circulating Tfh Cells Concordantly Shape the Neutralizing Antibody Responses in Individuals Who Have Recovered from Mild COVID-19 Open
Regulatory T (Treg) cells are involved in the antiviral immune response in patients with coronavirus disease 2019 (COVID-19); however, whether Treg cells are involved in the neutralizing antibody (nAb) response remains unclear. Here, we fo…
View article: Comprehensive clinical analysis of AKR1 expression profiles in the diagnosis of human colorectal cancer
Comprehensive clinical analysis of AKR1 expression profiles in the diagnosis of human colorectal cancer Open
Background: CRC has a high mortality rate, and early detection is essential to reducing the CRC-related mortality rate. Screening is inefficient for diagnosis based on the low detection rate, length of time consumed, and poor compliance, s…
View article: Monoclonal antibodies constructed from COVID-19 convalescent memory B cells exhibit potent binding activity to MERS-CoV spike S2 subunit and other human coronaviruses
Monoclonal antibodies constructed from COVID-19 convalescent memory B cells exhibit potent binding activity to MERS-CoV spike S2 subunit and other human coronaviruses Open
Introduction The Middle East respiratory syndrome coronavirus (MERS-CoV) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are two highly contagious coronaviruses causing MERS and COVID-19, respectively, without an effec…
View article: Spike-specific CXCR3<sup>+</sup> T<sub>FH</sub> cells play a dominant functional role in supporting antibody responses in SARS-CoV-2 infection and vaccination
Spike-specific CXCR3<sup>+</sup> T<sub>FH</sub> cells play a dominant functional role in supporting antibody responses in SARS-CoV-2 infection and vaccination Open
Summary CD4 + T follicular helper (T FH ) cells are required for high-quality antibody generation and maintenance. However, the longevity and functional role of these cells are poorly defined in COVID-19 convalescents and vaccine recipient…
View article: Muscle atrophy induced by overexpression of ALAS2 is related to muscle mitochondrial dysfunction
Muscle atrophy induced by overexpression of ALAS2 is related to muscle mitochondrial dysfunction Open
Background ALAS2 (delta-aminolevulinate synthase 2) is one of the two isoenzymes catalyzing the synthesis of delta-aminolevulinic acid (ALA), which is the first precursor of heme synthesis. ALAS2-overexpressing transgenic mice (Tg mice) sh…
View article: AKR1B10 confers resistance to radiotherapy via FFA/TLR4/NF-κB axis in nasopharyngeal carcinoma
AKR1B10 confers resistance to radiotherapy via FFA/TLR4/NF-κB axis in nasopharyngeal carcinoma Open
Nasopharyngeal carcinoma (NPC) is one kind of human head and neck cancers with high incidence in Southern China, Southeast Asia and North Africa. In spite of great innovations in radiation and chemotherapy treatments, the 5-year survival r…
View article: AKR1B10 promotes breast cancer cell proliferation and migration via the PI3K/AKT/NF-κB signaling pathway
AKR1B10 promotes breast cancer cell proliferation and migration via the PI3K/AKT/NF-κB signaling pathway Open
BackgroudAberrant expression of Aldo-Keto reductase family 1 member B10 (AKR1B10) has been observed during the progression of some human carcinomas. However, the expression pattern and clinical relevance of AKR1B10 in breast cancer (BC) ne…
View article: AKR1B10 promotes breast cancer cell migration and invasion via activation of ERK signaling
AKR1B10 promotes breast cancer cell migration and invasion via activation of ERK signaling Open
AKR1B10 is overexpressed in breast cancer, and promotes the migration and invasion of MCF-7 and BT-20 cells by activating ERK signaling pathway.
View article: Circulating tumor DNA: A potential biomarker from solid tumors' monitor to anticancer therapies
Circulating tumor DNA: A potential biomarker from solid tumors' monitor to anticancer therapies Open
Circulating tumor DNA (ctDNA) in the peripheral blood is a liquid biopsy that contains representative tumor information including gene mutations. ctDNA is a promising new avenue for real-time monitoring of tumor progression. As a noninvasi…
View article: The role of long non-coding RNAs in nasopharyngeal carcinoma: As systemic review
The role of long non-coding RNAs in nasopharyngeal carcinoma: As systemic review Open
Recent development of cutting edge research found that long noncoding RNAs (lncRNAs) plays important roles in carcinogenesis and progression. In Southeast Asia and North Africa, nasopharyngeal carcinoma (NPC) is the most common aggressive …
View article: Aldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment
Aldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment Open
Cytosolic NADPH-dependent reductase AKR1B10 is a member of the aldo-keto reductase (AKR) superfamily. This enzyme is normally expressed in the gastrointestinal tract. However, it is overexpressed in many solid tumors, such as hepatocarcino…