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ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes Open
The APOE ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). ApoE protein aggregation plays a central role in AD pathology, including the accumulation of β-amyloid (Aβ). Lipid-poor ApoE4 protein is prone…
The effects of apolipoprotein E genotype, α‐synuclein deficiency, and sex on brain synaptic and Alzheimer's disease–related pathology Open
Introduction Alzheimer's disease (AD) and synucleinopathies share common pathological mechanisms. Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for AD, also increases the risk for dementia in pure synucleinopathies. We …
Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins Open
Apolipoprotein E4 (apoE4), the leading genetic risk factor for Alzheimer's disease (AD), is less lipidated compared to the most common and AD-benign allele, apoE3. We have recently shown that i.p. injections of the ATP-binding cassette A1 …