Ronit Nir
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View article: Author response: Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism
Author response: Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism Open
View article: Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism
Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism Open
m6A is the most widespread mRNA modification and is primarily implicated in controlling mRNA stability. Fundamental questions pertaining to m6A are the extent to which it is dynamically modulated within cells and across stimuli, and the fo…
View article: Author response: Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism
Author response: Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism Open
View article: Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism
Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism Open
m6A is the most widespread mRNA modification and is primarily implicated in controlling mRNA stability. Fundamental questions pertaining to m6A are the extent to which it is dynamically modulated within cells and across stimuli, and the fo…
View article: A sequence-specific RNA acetylation catalyst
A sequence-specific RNA acetylation catalyst Open
N4-acetylcytidine (ac4C) is a ubiquitous RNA modification incorporated by cytidine acetyltransferase enzymes. Here, we report the biochemical characterization of Thermococcus kodakarensis Nat10 (TkNat10), an RNA acetyltransferase involved …
View article: A sequence-specific RNA acetylation catalyst
A sequence-specific RNA acetylation catalyst Open
N4-acetylcytidine (ac4C) is a ubiquitous RNA modification incorporated by cytidine acetyltransferase enzymes. Here, we report the biochemical characterization of Thermococcus kodakarensis Nat10 (TkNat10), an RNA acetyltransferase involved …
View article: Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism
Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism Open
m6A is the most widespread mRNA modification and is primarily implicated in controlling mRNA stability. Fundamental questions pertaining to m6A are the extent to which it is dynamically modulated within cells and across stimuli, and the fo…
View article: Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism
Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism Open
m6A is the most widespread mRNA modification and is primarily implicated in controlling mRNA stability. Fundamental questions pertaining to m6A are the extent to which it is dynamically modulated within cells and across stimuli, and the fo…
View article: Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism
Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism Open
m6A is the most widespread mRNA modification and is primarily implicated in controlling mRNA stability. Fundamental questions pertaining to m6A are the extent to which it is dynamically modulated within cells and across stimuli, and the fo…
View article: Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2
Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2 Open
Millions of adenosines are deaminated throughout the transcriptome by ADAR1 and/or ADAR2 at varying levels, raising the question of what are the determinants guiding substrate specificity and how these differ between the two enzymes. We mo…
View article: Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2
Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2 Open
Millions of adenosines are deaminated throughout the transcriptome by ADAR1 and ADAR2, modulating double-stranded RNA (dsRNA) immunogenicity and recoding mRNA. The high variability in the susceptibility of different adenosines to editing b…
View article: Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability Open
View article: A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA
A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA Open
RNA can be extensively modified post-transcriptionally with >170 covalent modifications, expanding its functional and structural repertoire. Pseudouridine (Ψ), the most abundant modified nucleoside in rRNA and tRNA, has recently been fo…
View article: Cloning of DNA oligo pools for in vitro expression
Cloning of DNA oligo pools for in vitro expression Open
View article: Deciphering the principles of the RNA editing code via large-scale systematic probing
Deciphering the principles of the RNA editing code via large-scale systematic probing Open
View article: Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping
Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping Open
View article: Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling
Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling Open
View article: Deciphering the ‘m<sup>6</sup>A code’ via quantitative profiling of m<sup>6</sup>A at single-nucleotide resolution
Deciphering the ‘m<sup>6</sup>A code’ via quantitative profiling of m<sup>6</sup>A at single-nucleotide resolution Open
N6-methyladenosine (m 6 A) is the most abundant modification on mRNA, and is implicated in critical roles in development, physiology and disease. The ability to map m 6 A using immunoprecipitation-based approaches has played a critical rol…
View article: Systematic interrogation of human promoters
Systematic interrogation of human promoters Open
Despite much research, our understanding of the architecture and cis -regulatory elements of human promoters is still lacking. Here, we devised a high-throughput assay to quantify the activity of approximately 15,000 fully designed sequenc…
View article: Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay
Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay Open
View article: The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution
The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution Open
View article: Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activity
Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activity Open
Translation of mRNAs through Internal Ribosome Entry Sites (IRESs) has emerged as a prominent mechanism of cellular and viral initiation. It supports cap-independent translation of select cellular genes under normal conditions, and in cond…
View article: Deciphering Transcriptional Regulation of Human Core Promoters
Deciphering Transcriptional Regulation of Human Core Promoters Open
Despite its pivotal role in regulating transcription, our understanding of core promoter function, architecture, and cis-regulatory elements is lacking. Here, we devised a highthroughput assay to quantify the activity of ∼15,000 fully desi…
View article: Corrigendum: TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code
Corrigendum: TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code Open
View article: TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code
TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code Open
Following synthesis, RNA can be modified with over 100 chemically distinct modifications, which can potentially regulate RNA expression post-transcriptionally. Pseudouridine (Ψ) was recently established to be widespread and dynamically reg…