Abstract Objective. Proton therapy is a precision-focused cancer treatment where accurate proton beam range monitoring is critical to ensure effective dose delivery. This can be achieved by prompt gamma (PG) detection with a Compton camera like the S ilicon Photomultiplier and Scintillating F iber based C ompton C amera (SiFi-CC). This study aims to show the feasibility of optimising the geometry of SiFi-CC Compton camera for verification of dose distribution via PG detection a genetic algorithm (GA). Approach. Th…

Abstract Objective. The objective of the presented study was to evaluate the feasibility of a coded-mask (CM) gamma camera for real-time range verification in proton therapy, addressing the need for a precise and efficient method of treatment monitoring. Approach. A CM gamma camera prototype was tested in clinical conditions. The setup incorporated a scintillator-based detection system and a structured tungsten collimator. The experiment consisted of the irradiation of PMMA phantom with proton beams of energies ra…

Abstract Recent years have shown an increased use of silicon photomultipliers (SiPM) in experiments as they are of reasonable cost, have relatively low power consumption and are easily available in a variety of form factors allowing for a large number of readout channels. At the same time, experiments are generating data at increasingly high rates requiring the use of more efficient readout systems. In this work, the dead time, efficiency, dynamic range, coincidence time resolution and energy resolution of five di…

The SiFi-CC group is developing a scintillating-fiber-based Compton camera for high-efficiency gamma-ray imaging, specifically tailored for online range verification in particle therapy. After thorough optimization studies, including the development of neural-network approaches for event selection, the capability of the prototype for detecting range deviations is being studied by using realistic Monte Carlo simulations. We have implemented a spectral-spatial reconstruction based on the LM-MLEM algorithm and spectr…

Objective: Proton therapy is a precision-focused cancer treatment where accurate proton beam range monitoring is critical to ensure effective dose delivery. This can be achieved by prompt gamma detection with a Compton camera like the SiFi-CC. This study aims to show the feasibility of optimising the geometry of SiFi-CC Compton camera for verification of dose distribution via prompt gamma detection using a genetic algorithm (GA). Approach: The SiFi-CC key geometric parameters for optimisation with the GA are the s…