Ronny Baber
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View article: Characteristics of a tattooed population and a possible role of tattoos as a risk factor for chronic diseases: Results from the LIFE-Adult-Study
Characteristics of a tattooed population and a possible role of tattoos as a risk factor for chronic diseases: Results from the LIFE-Adult-Study Open
Tattoos and permanent make-up (PMU) gain increasing popularity among the general population. There are indications that pigments or their fragments may translocate within the body, however knowledge about possible systemic adverse effects …
View article: Body composition predicts poor outcomes and reveals immunometabolic dysfunction via single-cell profiling in anti-BCMA CAR T-treated myeloma
Body composition predicts poor outcomes and reveals immunometabolic dysfunction via single-cell profiling in anti-BCMA CAR T-treated myeloma Open
Chimeric Antigen Receptor (CAR) T-cell therapy has transformed the treatment of relapsed or refractory multiple myeloma (RRMM), yet outcomes remain heterogenous. The prognostic role of body composition in this context is unknown. We retros…
View article: Prognostic significance of PET/CT for CAR T cell therapy in relapsed/refractory multiple myeloma
Prognostic significance of PET/CT for CAR T cell therapy in relapsed/refractory multiple myeloma Open
PET/CT plays an important role in staging of multiple myeloma (MM) and detecting extramedullary disease (EMD); however, its role in patients treated with commercially available CAR T cell therapies is unclear. We evaluated 61 patients trea…
View article: Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter
Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter Open
The retina is a relatively accessible part of the central nervous system compared to the brain. Using high resolution optical imaging we investigated the relationship between retinal thickness, obtained with optical coherence tomography, a…
View article: A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma
A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma Open
Chimeric Antigen Receptor (CAR) T-cell therapies targeting B-cell maturation antigen (BCMA) have transformed the treatment landscape for relapsed/refractory multiple myeloma (RRMM). In this study, we present a real world cohort of 61 RRMM …
View article: Pediatric reference values of VEGF-D derived from a German population-based cohort of healthy children
Pediatric reference values of VEGF-D derived from a German population-based cohort of healthy children Open
Knowing VEGF-D levels in growing healthy young children and adolescents could help to recognize early disease progression of LAM in individuals at risk especially young women suffering from TSC. Further studies are needed on VEGF-D serum l…
View article: Multidisciplinary assessment of the impact of assisted reproductive techniques on pregnancy and long-term outcomes of mother and child: Foundation of the LE-REP (Leipzig Reproductive Health) Center
Multidisciplinary assessment of the impact of assisted reproductive techniques on pregnancy and long-term outcomes of mother and child: Foundation of the LE-REP (Leipzig Reproductive Health) Center Open
About 8-10 % of all people of reproductive age are unable to conceive children. In recent years, an increased number of consultations for fertility treatments has been observed with a continuing positive trend. It is known that infertility…
View article: Effect of sex, pubertal stage, body mass index, oral contraceptive use, and C-reactive protein on vitamin D binding protein reference values
Effect of sex, pubertal stage, body mass index, oral contraceptive use, and C-reactive protein on vitamin D binding protein reference values Open
Objective Vitamin D binding protein (DBP) regulates the transport and availability of vitamin D. We aimed to establish age- and sex-specific reference ranges for serum concentrations of DBP in healthy infants, children, and adolescents. In…
View article: Characteristics of a tattooed population and a possible role of tattoos as a risk factor for chronic diseases: Results from the LIFE-Adult-Study
Characteristics of a tattooed population and a possible role of tattoos as a risk factor for chronic diseases: Results from the LIFE-Adult-Study Open
Tattoos and permanent make-up (PMU) gain increasing popularity among the general population. There are indications that pigments or their fragments may translocate within the body, however knowledge about possible systemic adverse effects …
View article: Data from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma
Data from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Open
Establishing a strategy for sequencing of T cell–redirecting therapies for relapsed/refractory multiple myeloma (RRMM) is a pressing clinical need. We longitudinally tracked the clinical and immunologic impact of bispecific T cell–engaging…
View article: Supplementary Figures S1-S14 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma
Supplementary Figures S1-S14 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Open
Fig. S1: PFS analysis of the BsAb vs other bridging groups. Fig. S2: Quantification of CAR-T cells using MFC vs PCR. Fig. S3: Correlation of sBCMA levels with IMWG response criteria. Fig. S4: PFS analysis of patients with higher vs lower t…
View article: Supplementary Table 1 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma
Supplementary Table 1 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Open
Overview of bridging therapies and clinical characteristics.
View article: Supplementary Table 3 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma
Supplementary Table 3 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Open
Detailed overview of all regimens administered as bridging therapy for each patient.
View article: Supplementary Figures S15-S19 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma
Supplementary Figures S15-S19 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Open
Fig. S15: Gating scheme used for quantification of CAR-T cells. Fig. S16: Gating scheme used for immune checkpoint marker detection on non-transduced and CAR-T cells. Fig. S17: Gating scheme used for T cell subsets. Fig. S18: Gating scheme…
View article: Supplementary Table 2 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma
Supplementary Table 2 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Open
Proportion of CAR-positive cells in T cell cultures from day 7 after CAR-T infusion used for the in vitro cytotoxicity assay.
View article: Tissue factor binds to and inhibits interferon-α receptor 1 signaling
Tissue factor binds to and inhibits interferon-α receptor 1 signaling Open
Tissue factor (TF), which is a member of the cytokine receptor family, promotes coagulation and coagulation-dependent inflammation. TF also exerts protective effects through unknown mechanisms. Here, we showed that TF bound to interferon-α…
View article: Relationship of proteins and subclinical cardiovascular traits in the population-based LIFE-Adult study
Relationship of proteins and subclinical cardiovascular traits in the population-based LIFE-Adult study Open
We extend the catalogue of proteome biomarkers possibly involved in early stages of cardiovascular disease pathologies providing targets for early risk prediction or intervention strategies.
View article: Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease
Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease Open
Coagulation factor XII (FXII) conveys various functions as an active protease that promotes thrombosis and inflammation, and as a zymogen via surface receptors like urokinase-type plasminogen activator receptor (uPAR). While plasma levels …
View article: Association of Whole Blood Amino Acid and Acylcarnitine Metabolome with Anthropometry and IGF-I Serum Levels in Healthy Children and Adolescents in Germany
Association of Whole Blood Amino Acid and Acylcarnitine Metabolome with Anthropometry and IGF-I Serum Levels in Healthy Children and Adolescents in Germany Open
Background: Physiological changes of blood amino acids and acylcarnitines during healthy child development are poorly studied. The LIFE (Leipziger Forschungszentrum für Zivilisationserkrankungen) Child study offers a platform with a large …
View article: Bilirubin Levels in Infancy and Their Associations with Body Weight, Levels of Iron-Related Parameters and Steroid Hormone Levels
Bilirubin Levels in Infancy and Their Associations with Body Weight, Levels of Iron-Related Parameters and Steroid Hormone Levels Open
It is assumed that bilirubin is hormonally regulated and influences weight development by preventing weight gain. However, studies in healthy infants are limited. The present study established reference values for bilirubin and investigate…
View article: Cellular dynamics following CAR T cell therapy are associated with response and toxicity in relapsed/refractory myeloma
Cellular dynamics following CAR T cell therapy are associated with response and toxicity in relapsed/refractory myeloma Open
View article: Mass Spectrometry Proteomics Characterization of Plasma Biomarkers for Colorectal Cancer Associated With Inflammation
Mass Spectrometry Proteomics Characterization of Plasma Biomarkers for Colorectal Cancer Associated With Inflammation Open
Background: Colorectal cancer (CRC) prognosis is determined by the disease stage with low survival rates for advanced stages. Current CRC screening programs are mainly using colonoscopy, limited by its invasiveness and high cost. Therefore…
View article: Tissue factor binds to and inhibits interferon-α receptor 1 signaling
Tissue factor binds to and inhibits interferon-α receptor 1 signaling Open
View article: Association of whole blood amino acid and acylcarnitine metabolome with anthropometry and IGF1 serum levels in healthy children and adolescents
Association of whole blood amino acid and acylcarnitine metabolome with anthropometry and IGF1 serum levels in healthy children and adolescents Open
Background: Physiological changes of blood amino acids and acylcarnitines during healthy child development are not well studied. The LIFE Child study offers a platform with a large cohort of healthy children to investigate these dynamics. …
View article: Cellular dynamics following CAR T cell therapy are associated with response and toxicity in relapsed/refractory myeloma
Cellular dynamics following CAR T cell therapy are associated with response and toxicity in relapsed/refractory myeloma Open
B cell maturation antigen (BCMA)-targeting chimeric antigen receptor (CAR) T cells revolutionized the treatment of relapsed/refractory multiple myeloma (RRMM). However, data on cellular (CAR) T cell dynamics and the association with respon…
View article: Genetic dissection of serum vaspin highlights its causal role in lipid metabolism
Genetic dissection of serum vaspin highlights its causal role in lipid metabolism Open
Objective Vaspin (visceral adipose tissue derived serine protease inhibitor, SERPINA12 ) is associated with obesity‐related metabolic traits, but its causative role is still elusive. The role of genetics in serum vaspin variability to esta…
View article: Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life
Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life Open
Transforming growth factor beta-1 (TGFβ1) is an adipokine secreted from adipose tissue, placental tissue and immune cells with a role in cell proliferation, cell apoptosis and angiogenic proliferation. The role of TGFβ1 in pregnancy and ch…
View article: Tracking of serum lipids in healthy children on a year-to-year basis
Tracking of serum lipids in healthy children on a year-to-year basis Open
Objectives To assess the stability of lipid profiles throughout childhood and evaluate their onset and dynamic. Materials and methods Lipid markers were longitudinally measured in more than 1300 healthy children from the LIFE Child study (…
View article: Leptin, but not ghrelin, is associated with food addiction scores in a population-based subject sample
Leptin, but not ghrelin, is associated with food addiction scores in a population-based subject sample Open
Background Ghrelin and leptin are both peptide hormones and act as opposing players in the regulation of hunger, satiety and energy expenditure. Leptin reduces appetite and feelings of hunger and is secreted mainly by adipocytes, while ghr…
View article: Childhood sexual abuse is associated with higher total ghrelin serum levels in adulthood: results from a large, population-based study
Childhood sexual abuse is associated with higher total ghrelin serum levels in adulthood: results from a large, population-based study Open