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View article: Incidence and risk factors for heart failure in the ELSA-Brasil cohort
Incidence and risk factors for heart failure in the ELSA-Brasil cohort Open
Background Heart failure (HF) is a clinical condition with high morbidity and mortality and a growing impact on global public health. Longitudinal studies with large samples and extended follow-up are essential to understand its incidence …
View article: Cognitive impairment in Chagas disease patients in Brazil, 2007–2021: A cross-sectional study
Cognitive impairment in Chagas disease patients in Brazil, 2007–2021: A cross-sectional study Open
Introduction Chagas Disease (CD) is frequently associated with heart failure (HF). Cognitive impairment is reported, but whether it results from CD or is a nonspecific symptom of HF is unknown. We aimed to compare cognitive function of HF …
View article: Promising results of ultrasound guided foam sclerotherapy for treating chronic venous ulcers
Promising results of ultrasound guided foam sclerotherapy for treating chronic venous ulcers Open
Most patients with chronic venous ulcers (CEAP 6) treated with foam sclerotherapy achieved healing or significant improvement within 52 weeks. Healing was highly influenced by time until treatment, ulcer size, reduced dorsiflexion of the a…
View article: Multidisciplinary nursing care in chronic Chagas disease: a scoping review
Multidisciplinary nursing care in chronic Chagas disease: a scoping review Open
Nurses play a critical role within a multidisciplinary care team in improving the health-related quality of life for individuals living with chronic Chagas disease, irrespective of the cardiac or digestive form of the disease. Therefore, i…
View article: Applicability of Machine Learning Algorithms in Diagnosis of Atrial Fibrillation and LQTS by Electrocardiogram Interpretation: A Systematic Review
Applicability of Machine Learning Algorithms in Diagnosis of Atrial Fibrillation and LQTS by Electrocardiogram Interpretation: A Systematic Review Open
Background Machine Learning (ML) is a type of algorithm that autonomously learns to recognize complex patterns. In the diagnostic context of cardiac arrhythmias, these algorithms have shown significant advancements due to their ability to …
View article: Survival Analysis and Factors Associated with Mortality in Heart Failure Patients in the ELSA-Brasil Cohort
Survival Analysis and Factors Associated with Mortality in Heart Failure Patients in the ELSA-Brasil Cohort Open
Background Heart failure (HF) is one of the leading causes of morbidity and mortality worldwide. Few studies have evaluated the survival and prognostic factors of patients with this condition in light of the therapeutic advances of recent …
View article: Endothelial Function by Flow-Mediated Dilation (FMD) in the Brachial Artery in Hypertensive Patients
Endothelial Function by Flow-Mediated Dilation (FMD) in the Brachial Artery in Hypertensive Patients Open
Background High blood pressure (BP) values have traditionally been associated with the risk of ischemic heart disease, stroke, chronic kidney disease, and early mortality. The brachial artery FMD after cuff deflation has become the standar…
View article: Adherence to Guideline-Directed Medical Therapy Target in patients with heart failure and reduced ejection fraction: a cross-sectional study
Adherence to Guideline-Directed Medical Therapy Target in patients with heart failure and reduced ejection fraction: a cross-sectional study Open
BACKGROUND: Heart failure with reduced ejection fraction (HFrEF) represents a compelling cause of hospital morbidity and mortality in Brazil. There is low adherence to guideline-directed medical therapy (GDMT), which in turn, can result in…
View article: The Action of Colchicine in Patients with Metabolic Syndrome and Obesity: Perspectives and Challenges
The Action of Colchicine in Patients with Metabolic Syndrome and Obesity: Perspectives and Challenges Open
Colchicine is an alkaloid traditionally used to treat inflammatory conditions such as gout and familial Mediterranean fever. Currently, there are proposals for the use of this drug in several other situations, such as cardiovascular and li…
View article: Effects of glibenclamide/glyburide on stroke: Systematic review
Effects of glibenclamide/glyburide on stroke: Systematic review Open
Glibenclamide (GBC), although traditionally used to treat type 2 diabetes mellitus, has demonstrated efficacy in preventing cerebral edema in the setting of stroke, including preserving the integrity of the vascular endothelium, reducing e…
View article: Impact of Stressors on The Mental and Physical Health of Professionals Working in Intensive Care Units During The COVID-19 Pandemic
Impact of Stressors on The Mental and Physical Health of Professionals Working in Intensive Care Units During The COVID-19 Pandemic Open
Stress-inducing factors experienced by professionals working in intensive care units (ICUs) during the COVID-19 pandemic have detrimental effects on their mental and physical well-being. The COVID-19 outbreak led to a surge in the number o…
View article: Can Triglycerides-HDL-C Ratio, HOMA-IR, ApoB, Non-HDL Cholesterol, and Free Cholesterol be Laboratory-Associated Flags of Female Coronary Atherosclerosis Regardless of Being Diabetic?
Can Triglycerides-HDL-C Ratio, HOMA-IR, ApoB, Non-HDL Cholesterol, and Free Cholesterol be Laboratory-Associated Flags of Female Coronary Atherosclerosis Regardless of Being Diabetic? Open
Aim The study aimed to evaluate biomarkers, ratios, and indexes as flags of coronary obstructions in women with established coronary atherosclerotic disease regardless of diabetes. Methods A cross-sectional study was conducted on 42 confir…
View article: Overexpression of miR-126-5p in the serum of patients with systemic arterial hypertension is correlated with creatinine and platelets
Overexpression of miR-126-5p in the serum of patients with systemic arterial hypertension is correlated with creatinine and platelets Open
Background: Systemic arterial hypertension is a multicausal and multifactorial disease of high prevalence worldwide. The development, progression, and damage of target organs are associated not only with genetic and environmental factors, …
View article: Stroke Is Associated with Refractory Hypertension among Resistant and Refractory Patients in a Cross-Sectional Study
Stroke Is Associated with Refractory Hypertension among Resistant and Refractory Patients in a Cross-Sectional Study Open
Background Refractory hypertension (RfH) is a severe phenotype of resistant hypertension (RH) linked to higher risk of stroke and other adverse cardiovascular events, but knowledge about it is still lacking. Objectives To evaluate the asso…
View article: Efficacy and Safety of Granulocyte-Colony Stimulating Factor Therapy in Chagas Cardiomyopathy: A Phase II Double-Blind, Randomized, Placebo-Controlled Clinical Trial
Efficacy and Safety of Granulocyte-Colony Stimulating Factor Therapy in Chagas Cardiomyopathy: A Phase II Double-Blind, Randomized, Placebo-Controlled Clinical Trial Open
Aim Previous studies showed that granulocyte-colony stimulating factor (G-CSF) improved heart function in a mice model of Chronic Chagas Cardiomyopathy (CCC). Herein, we report the interim results of the safety and efficacy of G-CSF therap…
View article: Simple Echocardiographic Parameters are Strong Predictors of the Cardiovascular Risk in Asymptomatic Individuals: Elsa-Brasil Cohort
Simple Echocardiographic Parameters are Strong Predictors of the Cardiovascular Risk in Asymptomatic Individuals: Elsa-Brasil Cohort Open
Background Several studies have evaluated echocardiographic abnormalities as predictors of cardiovascular risk; however, none have associated the global cardiovascular risk with echocardiographic abnormalities in the Brazilian population. …
View article: Within-Visit Blood Pressure Variability and Cardiovascular Risk in ELSA-Brasil Study Participants
Within-Visit Blood Pressure Variability and Cardiovascular Risk in ELSA-Brasil Study Participants Open
Background Blood pressure variability (BPV) is of prognostic value for fatal and non-fatal cardiovascular outcomes. Objective This study aimed to evaluate the association between within-visit BPV and cardiovascular risk among participants …
View article: Atrial Flutter in PRKAG2 Syndrome: Clinical and Electrophysiological Characteristics
Atrial Flutter in PRKAG2 Syndrome: Clinical and Electrophysiological Characteristics Open
Background PRKAG2 syndrome is a rare autosomal dominant disease, a phenocopy of hypertrophic cardiomyopathy characterized by intracellular glycogen accumulation. Clinical manifestations include ventricular preexcitation, cardiac conduction…
View article: Within-Visit Blood Pressure Variability and Cardiovascular Risk in ELSA-Brasil Study Participants
Within-Visit Blood Pressure Variability and Cardiovascular Risk in ELSA-Brasil Study Participants Open
Background Blood pressure variability (BPV) is of prognostic value for fatal and non-fatal cardiovascular outcomes. Objective This study aimed to evaluate the association between within-visit BPV and cardiovascular risk among participants …
View article: Tissue Inhibitor of Metalloproteinase-1 Is Increased in Chagasic Cardiomyopathy
Tissue Inhibitor of Metalloproteinase-1 Is Increased in Chagasic Cardiomyopathy Open
Chagas disease (CD) mainly conveys stroke risk through structural cardiac disease. However, stroke and cognitive impairment are seen in CD independently of cardiac disease severity. Chronic inflammation may be an explanation for this assoc…
View article: Clinical Characteristics and Therapeutic Adherence of Women in a Referral Outpatient Clinic for Severe Hypertension
Clinical Characteristics and Therapeutic Adherence of Women in a Referral Outpatient Clinic for Severe Hypertension Open
Background Cardiovascular disease is the main cause of death worldwide. There is a lack of studies addressing this issue in women and its risk factors, such as hypertension. Objective To evaluate the clinical and therapeutic profile of wom…
View article: Drug Profile and Therapeutic Adherence of African-Brazilians with Apparent Resistant Hypertension
Drug Profile and Therapeutic Adherence of African-Brazilians with Apparent Resistant Hypertension Open
Background Resistant hypertension (RH) is manifested by the presence of blood pressure values resistant to antihypertensive therapy. RH is highly prevalent among black individuals, increasing cardiovascular risk in this population and requ…
View article: Demographic and professional profile of Brazilian women in vascular surgery: final results
Demographic and professional profile of Brazilian women in vascular surgery: final results Open
Background Gender diversity in health teams is associated with better productivity. As women’s participation in surgery has been growing, it is important to improve knowledge about the elements that guide their professional development. Ob…
View article: Atrial High-Rate Episodes and Their Association with Cerebral Ischemic Events in Chagasic Patients
Atrial High-Rate Episodes and Their Association with Cerebral Ischemic Events in Chagasic Patients Open
Background Atrial high-rate episodes (AHREs) are associated with an increased risk of cerebral ischemic events; however, there are no studies related to the presence of AHREs and cerebral ischemic events in Chagasic patients. Objective To …
View article: The effects of the COVID-19 pandemic on levels of physical fitness
The effects of the COVID-19 pandemic on levels of physical fitness Open
SUMMARY INTRODUCTION The COVID-19 pandemic, caused by infections from a novel human coronavirus, has been reported since December 2019 in China but was only made official in March 2020. Since then, it has had an impact worldwide, both due …
View article: Association between Therapeutic Adherence and the Profile of Patients with Resistant Hypertension
Association between Therapeutic Adherence and the Profile of Patients with Resistant Hypertension Open
Background: Resistant hypertension (RH) consists of increased blood pressure (BP) despite the use of 3 or more antihypertensives or BP control only when is use of 4 or more antihypertensives. It is fundamental to exclude pseudoresistance, …
View article: Clinical Characteristics of Resistant vs. Refractory Hypertension in a Population of Hypertensive Afrodescendants
Clinical Characteristics of Resistant vs. Refractory Hypertension in a Population of Hypertensive Afrodescendants Open
Background Afrodescendants have been associated with a greater severity of arterial hypertension and a higher incidence of cardiovascular complications. Characteristics in the presentation of resistant hypertension (RH) or refractory hyper…
View article: Association between Therapeutic Adherence and the Profile of Patients with Resistant Hypertension
Association between Therapeutic Adherence and the Profile of Patients with Resistant Hypertension Open
Background: Resistant hypertension (RH) consists of increased blood pressure (BP) despite the use of 3 or more antihypertensives or BP control only when is use of 4 or more antihypertensives. It is fundamental to exclude pseudoresistance, …