Chen Wang
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View article: Early identification and diagnosis of fournier gangrene: a machine learning approach integrating serological characterization
Early identification and diagnosis of fournier gangrene: a machine learning approach integrating serological characterization Open
View article: Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke
Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke Open
BACKGROUND: Analyses of genomic and proteomics data in prospective biobank studies in diverse populations may discover novel or repurposing drug targets for stroke. METHODS: We extracted individual cis -protein quantitative trait locus for…
View article: Clinical characteristics, hospital days, hospitalization costs, and in-hospital mortality among patients in a dermatological intensive care unit: a single-center retrospective study from China
Clinical characteristics, hospital days, hospitalization costs, and in-hospital mortality among patients in a dermatological intensive care unit: a single-center retrospective study from China Open
Background Dermatological conditions can become extremely serious and cause life-threatening situations for affected patients, thereby necessitating intensive care. However, data from the dermatology intensive care unit (DICU) remain limit…
View article: Mechanistic insights into proton-coupled substrate translocation of nucleoside proton symporters
Mechanistic insights into proton-coupled substrate translocation of nucleoside proton symporters Open
View article: The natural product 3-Mercaptopropionic acid is a highly effective browning inhibitor by directly capturing polyphenol oxidase activity
The natural product 3-Mercaptopropionic acid is a highly effective browning inhibitor by directly capturing polyphenol oxidase activity Open
View article: GDF9His209GlnfsTer6/S428T and GDF9Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargement
GDF9His209GlnfsTer6/S428T and GDF9Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargement Open
Background Antral follicles consist of an oocyte cumulus complex surrounding by somatic cells, including mural granulosa cells as the inner layer and theca cells as the outsider layer. The communications between oocytes and granulosa cells…
View article: Combined analysis of estradiol and β-hCG to predict the early pregnancy outcome of FET: a retrospective study
Combined analysis of estradiol and β-hCG to predict the early pregnancy outcome of FET: a retrospective study Open
Background How to accurately predicting the pregnancy outcomes of an IVF cycle are particularly important. Although a lot of work was conducted to predict pregnancy outcomes by assaying serum β-hCG levels after embryo transfer, rare study …
View article: Efficacy and safety of the combination of oral tranexamic acid and intense pulsed light versus oral tranexamic acid alone in the treatment of refractory Riehl's melanosis: A prospective, comparative study
Efficacy and safety of the combination of oral tranexamic acid and intense pulsed light versus oral tranexamic acid alone in the treatment of refractory Riehl's melanosis: A prospective, comparative study Open
Background There is no standardized and effective treatment modality for Riehl's melanosis. Aims To compare the efficacy and safety of oral tranexamic acid (TXA) combined with intense pulsed light (IPL) versus TXA alone in the treatment of…
View article: Photoaffinity probe‐based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of <i>Plasmodium falciparum</i>
Photoaffinity probe‐based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of <i>Plasmodium falciparum</i> Open
Malaria continues to pose a serious global health threat, and artemisinin remains the core drug for global malaria control. However, the situation of malaria resistance has become increasingly severe due to the emergence and spread of arte…
View article: Suppression of endoplasmic reticulum stress by 4-PBA enhanced atherosclerotic plaque stability via up-regulating CLOCK expression
Suppression of endoplasmic reticulum stress by 4-PBA enhanced atherosclerotic plaque stability via up-regulating CLOCK expression Open
Endoplasmic reticulum (ER) stress refers to a condition where the normal functioning of the ER is disrupted due to a variety of cellular stress factors. As a result, there is an accumulation of unfolded and misfolded proteins within the ER…
View article: Field investigation combined with modeling uncovers the ecological heterogeneity of Aedes albopictus habitats for strategically improving systematic management during urbanization
Field investigation combined with modeling uncovers the ecological heterogeneity of Aedes albopictus habitats for strategically improving systematic management during urbanization Open
Background Aedes albopictus is an invasive vector of serious Aedes -borne diseases of global concern. Habitat management remains a critical factor for establishing a cost-effective systematic strategy for sustainable vector control. Howeve…
View article: Mid-term assessment of subtalar arthroereisis with Talar-Fit implant in pediatric patients with flexible flatfoot and comparing the difference between different sizes and exploring the position of the inserted implant
Mid-term assessment of subtalar arthroereisis with Talar-Fit implant in pediatric patients with flexible flatfoot and comparing the difference between different sizes and exploring the position of the inserted implant Open
Background Subtalar arthroereisis (STA) has gained growing acceptance as a viable approach solution for the management of pediatric flexible flatfoot. However, STA still remains controversial. The purpose of this study is to assess the eff…
View article: Effect of a Semi-rigid Ankle Brace on the In Vivo Kinematics and Muscle Activity of Patients with Functional Ankle Instability During Simulated Ankle Sprain
Effect of a Semi-rigid Ankle Brace on the In Vivo Kinematics and Muscle Activity of Patients with Functional Ankle Instability During Simulated Ankle Sprain Open
Background Ankle braces can effectively decrease the incidence of recurrent ankle sprain; however, whether the brace can decrease the severity of sprain and its related mechanism during sprain remain unknown. Methods 22 patients with funct…
View article: Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1
Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1 Open
By lacking de novo purine biosynthesis enzymes, Plasmodium falciparum requires purine nucleoside uptake from host cells. The indispensable nucleoside transporter ENT1 of P. falciparum facilitates nucleoside uptake in the asexual blood stag…
View article: Diagnostic Evaluation of Mechanical Ankle Instability by Comparing Injured and Uninjured Contralateral Ankles Using Arthrometry
Diagnostic Evaluation of Mechanical Ankle Instability by Comparing Injured and Uninjured Contralateral Ankles Using Arthrometry Open
Context Individuals with mechanical ankle instability (MAI) have obvious lateral ligament laxity and excessive ankle joint motion beyond the physiological range. Arthrometry has been introduced to quantitatively measure the laxity of the a…
View article: Bibliometric insights in fournier's gangrene: Research landscapes, turning points, and global trends
Bibliometric insights in fournier's gangrene: Research landscapes, turning points, and global trends Open
Study Design Bibliometric and visualization analysis. Objective To analyze the research landscapes and hotspots of Fournier's gangrene, and reveal the dynamic changes and development trend of research hotspots for the purpose of providing …
View article: In Vivo Evaluation of the Position and Orientation of the Geometric Axis of the Tibiotalar Joint
In Vivo Evaluation of the Position and Orientation of the Geometric Axis of the Tibiotalar Joint Open
Background. Fitting the surface morphology of the talar trochlea is one of the common methods to define the geometric axis of the tibiotalar joint (GATJ). However, the in vivo motion of such axis during gait has not been fully investigated…
View article: The structural basis of itch receptor MRGPRX1 activation
The structural basis of itch receptor MRGPRX1 activation Open
Mas-related G-protein-coupled receptors X1-X4 (MRGPRX1-X4) are four primate-specific receptors that are recently reported to be responsible for many biological processes, including itch sensation, pain transmission, and inflammatory reacti…
View article: 590 nm LED Irradiation Improved Erythema through Inhibiting Angiogenesis of Human Microvascular Endothelial Cells and Ameliorated Pigmentation in Melasma
590 nm LED Irradiation Improved Erythema through Inhibiting Angiogenesis of Human Microvascular Endothelial Cells and Ameliorated Pigmentation in Melasma Open
Melasma is a common refractory acquired pigmentary skin disease that mainly affects middle-aged women. The pathogenesis of melasma is still uncertain, while abnormal vascular endothelial cells may play a role. We previously demonstrated th…
View article: Titanium dioxide nanotubes increase purinergic receptor P2Y6 expression and activate its downstream PKCα-ERK1/2 pathway in bone marrow mesenchymal stem cells under osteogenic induction
Titanium dioxide nanotubes increase purinergic receptor P2Y6 expression and activate its downstream PKCα-ERK1/2 pathway in bone marrow mesenchymal stem cells under osteogenic induction Open
Titanium dioxide (TiO2) nanotubes can improve the osseointegration of pure titanium implants, but this exact mechanism has not been fully elucidated. The purinergic receptor P2Y6 is expressed in bone marrow mesenchymal stem cell…
View article: Long‑term remission under Disitamab Vedotin (RC48) in HR‑positive/HER2‑positive metastatic breast cancer with brain meningeal, and bone marrow involvement: A case report
Long‑term remission under Disitamab Vedotin (RC48) in HR‑positive/HER2‑positive metastatic breast cancer with brain meningeal, and bone marrow involvement: A case report Open
Breast cancer (BC) with overexpression of human epidermal growth factor receptor 2 (HER2) is closely associated with an elevated risk of multiple distant metastases and unfavorable prognosis. Disitamab Vedotin (RC48) is a newly developed a…
View article: The influence of local pain on balance control in patients with chronic ankle instability
The influence of local pain on balance control in patients with chronic ankle instability Open
Background Local pain around the ankle joint is a common symptom in patients with chronic ankle instability (CAI). However, whether the local pain would impose any influence on the balance control performance of CAI patients is still unkno…
View article: Effects of Tea Treatments against High-Fat Diet-Induced Disorder by Regulating Lipid Metabolism and the Gut Microbiota
Effects of Tea Treatments against High-Fat Diet-Induced Disorder by Regulating Lipid Metabolism and the Gut Microbiota Open
High-fat diet (HFD) may induce changes of metabolism and gut microbiota changes, and these changes are susceptible to diet adjustments such as tea treatment. However, the treatment effects may vary among different types of tea. In this stu…
View article: Quantitative analysis with load–displacement ratio measured via digital arthrometer in the diagnostic evaluation of chronic ankle instability: a cross-sectional study
Quantitative analysis with load–displacement ratio measured via digital arthrometer in the diagnostic evaluation of chronic ankle instability: a cross-sectional study Open
View article: Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people
Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people Open
View article: Effect of a Semi-rigid Ankle Brace on the In Vivo Kinematics and Muscle Activity of Patients with Functional Ankle Instability Duing Simulated Ankle Sprain
Effect of a Semi-rigid Ankle Brace on the In Vivo Kinematics and Muscle Activity of Patients with Functional Ankle Instability Duing Simulated Ankle Sprain Open
Background Ankle braces can effectively decrease the incidence of recurrent ankle sprain; however, whether the brace can decrease the severity of sprain and its related mechanism during sprain remain unknown. Methods 12 patients with funct…
View article: Percutaneous Inferior Extensor Retinaculum Augmentation Technique for Chronic Ankle Instability
Percutaneous Inferior Extensor Retinaculum Augmentation Technique for Chronic Ankle Instability Open
Objective To specify indications and contraindications of the modified percutaneous inferior extensor retinaculum augmentation (PIERA) technique for chronic ankle instability cases, and to introduce technique details and report surgical ou…
View article: Preoperative Lymphocyte‐to‐Monocyte Ratio Can Indicate the Outcomes in Repair of I‐III Degree Injury of Lateral Ankle Ligament
Preoperative Lymphocyte‐to‐Monocyte Ratio Can Indicate the Outcomes in Repair of I‐III Degree Injury of Lateral Ankle Ligament Open
Background . This study is aimed at exploring the prognostic value of preoperative lymphocyte‐to‐monocyte ratio (LMR), an index of systemic inflammation before operation, in ankle lateral ligament repair (ALLR). Methods . A total of 213 I‐…
View article: Hair Shedding Evaluation for Alopecia: A Refined Wash Test
Hair Shedding Evaluation for Alopecia: A Refined Wash Test Open
Xiangqian Li, Xianghe Wang, Chen Wang, Jianzhong Zhang, Cheng Zhou Department of Dermatology, Peking University People’s Hospital, Beijing, People’s Republic of ChinaCorrespondence: Cheng ZhouDepartment of Dermatology, Peking University Pe…
View article: Titanium Dioxide Nanotubes Increase Purinergic Receptor P2Y6 Expression and Activate its Downstream PKCα-ERK1/2 Pathway in Bone Marrow Mesenchymal Stem Cells Under Osteogenic Induction
Titanium Dioxide Nanotubes Increase Purinergic Receptor P2Y6 Expression and Activate its Downstream PKCα-ERK1/2 Pathway in Bone Marrow Mesenchymal Stem Cells Under Osteogenic Induction Open