Rory Doolan
YOU?
Author Swipe
View article: Schistosoma immune evasion of NETosis is reversed by aryl hydantoin Ro 13-3978
Schistosoma immune evasion of NETosis is reversed by aryl hydantoin Ro 13-3978 Open
Schistosomiasis remains a major global health burden, with praziquantel as the only available treatment despite limitations such as reduced efficacy against juvenile stages. Aryl hydantoins such as Ro 13-3978 (AR02) and its derivative AR10…
View article: Screening of the Pathogen box reveals novel anti blood-feeding compounds
Screening of the Pathogen box reveals novel anti blood-feeding compounds Open
Soil-transmitted helminth (STH) infections such as Necator americanus infect millions globally, and are a major cause of anemia and developmental stunting in low and middle income countries. Blood-feeding hookworms in particular rely on th…
View article: The developmental lipidome of Nippostrongylus brasiliensis
The developmental lipidome of Nippostrongylus brasiliensis Open
Background Nippostrongylus brasiliensis —a nematode of rodents—is commonly used as a model to study the immunobiology of parasitic nematodes. It is a member of the Strongylida—a large order of socioeconomically important parasitic nematode…
View article: Holding glycolysis in check though Alox15 activity is required for macrophage M2 commitment and function in tissue repair and anti-helminth immunity
Holding glycolysis in check though Alox15 activity is required for macrophage M2 commitment and function in tissue repair and anti-helminth immunity Open
Macrophage polarization by type-2 cytokines is central to anti-helminth immunity and tissue repair. While some hallmark changes in macrophages are well-characterized and associated with protection against helminths, it is still unclear how…
View article: How to train your myeloid cells: a way forward for helminth vaccines?
How to train your myeloid cells: a way forward for helminth vaccines? Open
Soil-transmitted helminths affect approximately 1.5 billion people worldwide. However, as no vaccine is currently available for humans, the current strategy for elimination as a public health problem relies on preventive chemotherapy. Desp…
View article: Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway
Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway Open
Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in disadvantaged communities. Infections can cause high morbidity due to their impact on nutrient uptake and the…
View article: β‐Glucan receptors on IL‐4 activated macrophages are required for hookworm larvae recognition and trapping
β‐Glucan receptors on IL‐4 activated macrophages are required for hookworm larvae recognition and trapping Open
Recent advances in the field of host immunity against parasitic nematodes have revealed the importance of macrophages in trapping tissue migratory larvae. Protective immune mechanisms against the rodent hookworm Nippostrongylus brasiliensi…
View article: Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis
Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis Open
In Hookworm infection, neutrophils have long had the image of the villain, being recruited to the site of larval migration because of damage but participating themselves in tissue injury. With recent developments in neutrophil biology, the…
View article: Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products Open
Helminth parasites are adept manipulators of the immune system, using multiple strategies to evade the host type 2 response. In the intestinal niche, the epithelium is crucial for initiating type 2 immunity via tuft cells, which together w…