Rory Henderson
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View article: Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening
Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening Open
The hydrophobic fusion peptide (FP), a critical component of the HIV-1 entry machinery, is located at the N terminal stretch of the envelope (Env) gp41 subunit1-3. The receptor-binding gp120 subunit of Env forms a heterodimer with gp41 and…
View article: Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies
Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies Open
Vaccine development targeting rapidly evolving pathogens such as HIV-1 requires induction of broadly neutralizing antibodies (bnAbs) with conserved paratopes and mutations, and in some cases, the same Ig-heavy chains. The current trial-and…
View article: Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening
Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening Open
The hydrophobic fusion peptide (FP), a critical component of the HIV-1 entry machinery, is located at the N terminal stretch of the envelope (Env) gp41 subunit 1–3 . The receptor-binding gp120 subunit of Env forms a heterodimer with gp41 a…
View article: A systematic review of the factors associated with the psychological wellbeing of people with Parkinson’s in the COVID-19 pandemic
A systematic review of the factors associated with the psychological wellbeing of people with Parkinson’s in the COVID-19 pandemic Open
The implications of this review are not limited to preparing for future pandemics but can also be applied to more common concerns with comparable contextual characteristics such as yearly flu outbreaks, social isolation, and economic uncer…
View article: SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition
SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition Open
A recombinant lineage of the SARS-CoV-2 Omicron variant, named XBB, appeared in late 2022 and evolved descendants that successively swept local and global populations. XBB lineage members were noted for their improved immune evasion and tr…
View article: Microsecond dynamics control the HIV-1 Envelope conformation
Microsecond dynamics control the HIV-1 Envelope conformation Open
The HIV-1 Envelope (Env) glycoprotein facilitates host cell fusion through a complex series of receptor-induced structural changes. Although remarkable progress has been made in understanding the structures of various Env conformations, mi…
View article: Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates
Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates Open
Immunization with mRNA or viral vectors encoding spike with diproline substitutions (S-2P) has provided protective immunity against severe COVID-19 disease. How immunization with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)…
View article: Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies
Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies Open
Vaccine development targeting rapidly evolving pathogens such as HIV-1 requires induction of broadly neutralizing antibodies (bnAbs) with conserved paratopes and mutations, and, in some cases, the same Ig-heavy chains. The current trial-an…
View article: Microsecond dynamics control the HIV-1 envelope conformation
Microsecond dynamics control the HIV-1 envelope conformation Open
The HIV-1 Envelope (Env) glycoprotein facilitates host cell fusion through a complex series of receptor-induced structural changes. Although significant progress has been made in understanding the structures of various Env conformations an…
View article: Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques
Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques Open
SUMMARY The CD4 binding site (CD4bs) is a conserved epitope on HIV-1 envelope (Env) that can be targeted by protective broadly neutralizing antibodies (bnAbs). HIV-1 vaccines have not elicited CD4bs bnAbs for many reasons, including the CD…
View article: Network analysis uncovers the communication structure of SARS-CoV-2 spike protein identifying sites for immunogen design
Network analysis uncovers the communication structure of SARS-CoV-2 spike protein identifying sites for immunogen design Open
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has triggered myriad efforts to understand the structure and dynamics of this complex pathogen. The spike glycoprotein of SARS-CoV-2 is a significant target for immunogens as it is the…
View article: Mutation-Guided Vaccine Design: A Strategy for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction
Mutation-Guided Vaccine Design: A Strategy for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction Open
A major goal of HIV-1 vaccine development is induction of broadly neutralizing antibodies (bnAbs). While success has been achieved in initiating bnAb B cell lineages, design of boosting immunogens that select for bnAb B cell receptors with…
View article: Structural basis for breadth development in a HIV-1 neutralizing antibody
Structural basis for breadth development in a HIV-1 neutralizing antibody Open
Antibody affinity maturation enables adaptive immune responses to a wide range of pathogens. In some individuals broadly neutralizing antibodies develop to recognize rapidly mutating pathogens with extensive sequence diversity. Vaccine des…
View article: Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike
Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2 sub-lineage has gained in proportion relative to BA.1. Because spike (S) protein variations may underlie differences in their pathobiology, here we determine cry…
View article: Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike
Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike Open
Summary The BA.2 sub-lineage of the SARS-CoV-2 Omicron variant has gained in proportion relative to BA.1. As differences in spike (S) proteins may underlie differences in their pathobiology, here we determine cryo-EM structures of a BA.2 S…
View article: mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice
mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice Open
The success of nucleoside-modified mRNAs in lipid nanoparticles (mRNA-LNP) as COVID-19 vaccines heralded a new era of vaccine development. For HIV-1, multivalent envelope (Env) trimer protein nanoparticles are superior immunogens compared …
View article: Structural diversity of the SARS-CoV-2 Omicron spike
Structural diversity of the SARS-CoV-2 Omicron spike Open
Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the previously dominant Delta variant. Spike conformation plays an essential role in SARS-CoV-2 evolution via changes in receptor binding domain (RBD) and n…
View article: Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles
Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles Open
SUMMARY The success of nucleoside-modified mRNAs in lipid nanoparticles (mRNA-LNP) as COVID-19 vaccines heralded a new era of vaccine development. For HIV-1, multivalent envelope (Env) trimer protein nanoparticles are superior immunogens c…
View article: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity Open
SARS-CoV-2 from alpha to epsilon As battles to contain the COVID-19 pandemic continue, attention is focused on emerging variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that have been deemed variants of co…