Rory Wolfe
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View article: The Effect of Treating Hearing Loss with Hearing Aids on Plasma Biomarkers of Alzheimer's Disease and Related Dementias
The Effect of Treating Hearing Loss with Hearing Aids on Plasma Biomarkers of Alzheimer's Disease and Related Dementias Open
Background: Promising evidence indicates that treating hearing loss with hearing aids (HAs) could reduce dementia risk. We extend this evidence by investigating the effect of HAs on plasma biomarkers of Alzheimer's disease and related deme…
View article: Late-life, visit-to-visit blood pressure variability and its association with sex-specific long-term cognitive outcomes
Late-life, visit-to-visit blood pressure variability and its association with sex-specific long-term cognitive outcomes Open
In 19 114 community-dwelling older adults enrolled in the ASPREE trial, high late-life visit-to-visit blood pressure variability (BPV) was associated with increased risks of incident dementia and cognitive decline during the median 4.7 yea…
View article: Development and Validation of Polygenic Scores for Retinal Vessel Calibers
Development and Validation of Polygenic Scores for Retinal Vessel Calibers Open
PGSs for CRAE and CRVE are associated with measured retinal microvascular phenotypes. These findings illustrate the genetic contribution to retinal vessel calibers and provide insights into mechanisms of microvascular and macrovascular hea…
View article: Effect of Aspirin on Development of First and Recurrent Primary Cutaneous Keratinocyte Carcinomas in Older Australian Adults: Extended Follow-up of a Large Randomised Controlled Trial
Effect of Aspirin on Development of First and Recurrent Primary Cutaneous Keratinocyte Carcinomas in Older Australian Adults: Extended Follow-up of a Large Randomised Controlled Trial Open
Keratinocyte carcinomas (KC) are the most frequent cancers diagnosed in Australia and impart the largest economic cost of all cancers. Predisposed individuals tend to develop multiple KC over their lifetime. Data from the ASPirin in Reduci…
View article: Effect of aspirin on grip strength and gait speed in community-dwelling older adults in the ASPirin in Reducing Events in the Elderly (ASPREE) Study
Effect of aspirin on grip strength and gait speed in community-dwelling older adults in the ASPirin in Reducing Events in the Elderly (ASPREE) Study Open
Background Grip strength and gait speed are key markers of physical functional capacity and general health in older people. This study aimed to examine the effect of low-dose aspirin on handgrip strength and habitual gait speed in relative…
View article: Aspirin and healthy lifespan in older people: main outcome of the ASPREE-XT observational study
Aspirin and healthy lifespan in older people: main outcome of the ASPREE-XT observational study Open
National Institute on Aging and the National Cancer Institute (USA).
View article: Long‐Term Blood Pressure Variability and Physical Performance in Older Adults
Long‐Term Blood Pressure Variability and Physical Performance in Older Adults Open
High variability in long‐term blood pressure (BPV) independently predicts cardiovascular disease and cognitive decline. Increased BPV and declining physical performance may share mechanistic pathways. However, associations of BPV with gait…
View article: The effect of low-dose aspirin on reversing frailty status in older prefrail and frail adults: a secondary analysis of the ASPREE randomised clinical trial
The effect of low-dose aspirin on reversing frailty status in older prefrail and frail adults: a secondary analysis of the ASPREE randomised clinical trial Open
Background Chronic low-grade inflammation is hypothesised as a central driver of frailty. This study aims to evaluate whether low-dose aspirin can reverse frailty status among initially prefrail/frail older adults. Methods This was a post …
View article: The association of retinal vessel calibre, white matter hyperintensities and cognitive decline in community-dwelling older adults
The association of retinal vessel calibre, white matter hyperintensities and cognitive decline in community-dwelling older adults Open
Background Retinal vessel calibres (RVCs) are non-invasive markers of microvascular health and may serve as accessible indicators of cerebral small vessel disease (CSVD) and future cognitive impairment. This study examines whether RVCs are…
View article: Moderate Alcohol Consumption and Risk of Depression: A Longitudinal Analysis in Community-Dwelling Older Adults
Moderate Alcohol Consumption and Risk of Depression: A Longitudinal Analysis in Community-Dwelling Older Adults Open
Background/Objectives: Evidence suggests a J-shaped association between alcohol consumption and depression, but it remains unclear whether this reflects a true causal effect, reverse causation, or methodological bias. This uncertainty is p…
View article: Cognitive trajectories and incident atrial fibrillation in the ASPREE cohort
Cognitive trajectories and incident atrial fibrillation in the ASPREE cohort Open
Background Atrial fibrillation (AF) is associated with aging and increased risk of stroke and dementia. We examined the association between incident AF and cognitive trajectories in older adults using longitudinal data from the ASPirin in …
View article: Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial
Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial Open
Background and Aims Guidelines recommend against routine initiation of low-dose aspirin in older adults for primary prevention of atherosclerotic cardiovascular disease events. This study aimed to estimate long-term and post-trial effects …
View article: STAREE-HEART: A randomized placebo-controlled trial of atorvastatin effects on a marker of cardiac aging in older individuals without prior cardiovascular disease events: Protocol and baseline description of participants
STAREE-HEART: A randomized placebo-controlled trial of atorvastatin effects on a marker of cardiac aging in older individuals without prior cardiovascular disease events: Protocol and baseline description of participants Open
clinicaltrials.gov. Unique identifier: NCT04536870.
View article: Chemoprevention of Keratinocyte Cancers: Could Aspirin Be the Solution?
Chemoprevention of Keratinocyte Cancers: Could Aspirin Be the Solution? Open
Keratinocyte cancer burden is escalating, particularly in older Australian adults, where the incidence was > 6,000/100,000 in persons aged 80 to 84 per year, compared with 26/100,000 in persons aged 20 to 24 per year, in Queensland between…
View article: Incidence of major health events across metropolitan and regional areas: A 10+ year prospective study of 16,697 older Australians
Incidence of major health events across metropolitan and regional areas: A 10+ year prospective study of 16,697 older Australians Open
Objective To examine the prevalence of health risk factors by rurality status and the association of rurality and incidence of disability‐free survival (DFS), its components (death, dementia and physical disability), cardiovascular disease…
View article: Prevalence of Actionable Pharmacogenetic Genotype Frequencies, Cautionary Medication Use, and Polypharmacy in Community‐Dwelling Older Adults
Prevalence of Actionable Pharmacogenetic Genotype Frequencies, Cautionary Medication Use, and Polypharmacy in Community‐Dwelling Older Adults Open
Older adults (65 years and over) frequently manage complex medication regimens and are vulnerable to adverse drug reactions and treatment inefficacies, some of which could be preventable with pharmacogenetics (PGx)‐guided prescribing. This…
View article: Association of albuminuria with incident atrial fibrillation in healthy older adults
Association of albuminuria with incident atrial fibrillation in healthy older adults Open
Background Development of atrial fibrillation (AF) portends an increased risk of adverse cardiovascular outcomes. Relatively little is known about the longitudinal association between urine albumin excretion and the development of AF, part…
View article: Frailty incidence by diabetes treatment regimens in older adults with diabetes mellitus in the ASPirin in Reducing Events in the Elderly Study
Frailty incidence by diabetes treatment regimens in older adults with diabetes mellitus in the ASPirin in Reducing Events in the Elderly Study Open
Diabetes mellitus is a major risk factor for frailty in older adults, and studies suggest that frailty risk may differ by diabetes treatment regimen. To investigate the association between diabetes medication use and frailty, we conducted …
View article: Associations between blood sex hormones, cognitive decline and incident dementia in community-dwelling older Australian women: a prospective cohort study
Associations between blood sex hormones, cognitive decline and incident dementia in community-dwelling older Australian women: a prospective cohort study Open
The finding of a greater likelihood of a decline in executive function and verbal fluency in community-dwelling older women with the highest blood concentrations of DHEA and its metabolite estrone need reaffirmation and their clinical sign…
View article: A randomised clinical trial of STAtin therapy for Reducing Events in the Elderly (STAREE): Statistical analysis plan
A randomised clinical trial of STAtin therapy for Reducing Events in the Elderly (STAREE): Statistical analysis plan Open
The STAREE randomised controlled trial of 9971 community-dwelling older adults without cardiovascular disease, diabetes or dementia is designed to compare daily 40mg atorvastatin to placebo. We present a statistical analysis plan to pre-sp…
View article: Cardiometabolic Trajectories Preceding Dementia in Community-Dwelling Older Individuals
Cardiometabolic Trajectories Preceding Dementia in Community-Dwelling Older Individuals Open
Importance Poor cardiometabolic health is a risk factor associated with cognitive impairment in later life, but it remains unclear whether cardiometabolic trajectories can serve as early markers associated with dementia. Objective To compa…
View article: Moving beyond the prevalent exposure design for causal inference in dementia research
Moving beyond the prevalent exposure design for causal inference in dementia research Open
As randomised trials are not always feasible or practical, observational studies remain crucial for addressing many causal questions in the dementia prevention field. Through a systematic search, we found that 84 (72%) of the 116 latest ob…
View article: Association of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults
Association of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults Open
Tracking variability of TC and LDL-c may serve as a novel biomarker of incident dementia and cognitive decline in older adults.
View article: Egg Consumption and Mortality: A Prospective Cohort Study of Australian Community-Dwelling Older Adults
Egg Consumption and Mortality: A Prospective Cohort Study of Australian Community-Dwelling Older Adults Open
Background/Objectives: Egg consumption in adults has been linked with a modestly increased risk of all-cause and CVD mortality. However, evidence on adults aged 65 y+ is limited. The objective of this study was to investigate the associati…