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Sex and smoking bias in the selection of somatic mutations in human bladder Open
Men are at higher risk of several cancer types than women 1 . For bladder cancer the risk is four times higher for reasons that are not clear 2 . Smoking is also a principal risk factor for several tumour types, including bladder cancer 3 …
Colonic Mucosal Gene Expression Profile in Patients with Neoplastic Progression in Longstanding Ulcerative Colitis Open
The inflamed colonic mucosa from UC patients who have progressed to dysplasia or cancer has a different gene expression profile than that of UC non-progressors, suggesting lower levels of lymphoid organ-initiating and immune cell-attractin…
View article: Ultra-deep mutational landscape in chronic lymphocytic leukemia uncovers dynamics of resistance to targeted therapies
Ultra-deep mutational landscape in chronic lymphocytic leukemia uncovers dynamics of resistance to targeted therapies Open
BTK inhibitors, Bcl-2 inhibitors, and other targeted therapies have significantly improved outcomes for patients with chronic lymphocytic leukemia (CLL). With increased survivorship, monitoring disease and deciphering potential mechanisms …
Supplementary Tables 1-6 from Uterine Lavage Identifies Cancer Mutations and Increased <i>TP53</i> Somatic Mutation Burden in Individuals with Ovarian Cancer Open
Table S1. Clinical patient informationTable S2. Duplex Sequencing gene targetsTable S3. Custom probes for hotspotsTable S4. Mutation Frequency and Mutation Burden by patient and geneTable S5. Codons most frequently mutated in ovarian cance…
Data from Uterine Lavage Identifies Cancer Mutations and Increased <i>TP53</i> Somatic Mutation Burden in Individuals with Ovarian Cancer Open
Current screening methods for ovarian cancer have failed to demonstrate a significant reduction in mortality. Uterine lavage combined with TP53 ultradeep sequencing for the detection of disseminated ovarian cancer cells has emerged as a pr…
Supplementary Methods from Uterine Lavage Identifies Cancer Mutations and Increased <i>TP53</i> Somatic Mutation Burden in Individuals with Ovarian Cancer Open
Supplementary Methods
Data from Uterine Lavage Identifies Cancer Mutations and Increased <i>TP53</i> Somatic Mutation Burden in Individuals with Ovarian Cancer Open
Current screening methods for ovarian cancer have failed to demonstrate a significant reduction in mortality. Uterine lavage combined with TP53 ultradeep sequencing for the detection of disseminated ovarian cancer cells has emerged as a pr…
Supplementary Tables 1-6 from Uterine Lavage Identifies Cancer Mutations and Increased <i>TP53</i> Somatic Mutation Burden in Individuals with Ovarian Cancer Open
Table S1. Clinical patient informationTable S2. Duplex Sequencing gene targetsTable S3. Custom probes for hotspotsTable S4. Mutation Frequency and Mutation Burden by patient and geneTable S5. Codons most frequently mutated in ovarian cance…
Supplementary Figures 1-11 from Uterine Lavage Identifies Cancer Mutations and Increased <i>TP53</i> Somatic Mutation Burden in Individuals with Ovarian Cancer Open
S1. Experimental designS2. Association between the variant allele frequency (VAF) of tumor mutations identified in uterine lavage with stage of the ovarian cancer (A) and preoperative CA-125 level (B)S3. Gene distribution of the largest mu…
Supplementary Figures 1-11 from Uterine Lavage Identifies Cancer Mutations and Increased <i>TP53</i> Somatic Mutation Burden in Individuals with Ovarian Cancer Open
S1. Experimental designS2. Association between the variant allele frequency (VAF) of tumor mutations identified in uterine lavage with stage of the ovarian cancer (A) and preoperative CA-125 level (B)S3. Gene distribution of the largest mu…
Supplementary Methods from Uterine Lavage Identifies Cancer Mutations and Increased <i>TP53</i> Somatic Mutation Burden in Individuals with Ovarian Cancer Open
Supplementary Methods
Supplementary Methods from Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer Open
Supplementary Methods
Supplementary Figures 1-12 from Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer Open
Figure S1.Histology of UC colon tissue. Figure S2. Clonal expansions Figure S3. Clonal and Subclonal Mutations by Biopsy Figure S4. Association between mutation number and total DCS nucleotides sequenced. Figure S5. Association of Clonal a…
Supplementary Tables 1-3 from Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer Open
Table S1. Patient Information. Table S2. Biopsy Information. Table S3. Mutation Information.
Supplementary Figures 1-12 from Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer Open
Figure S1.Histology of UC colon tissue. Figure S2. Clonal expansions Figure S3. Clonal and Subclonal Mutations by Biopsy Figure S4. Association between mutation number and total DCS nucleotides sequenced. Figure S5. Association of Clonal a…
Supplementary Tables 1-3 from Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer Open
Table S1. Patient Information. Table S2. Biopsy Information. Table S3. Mutation Information.
Supplementary Methods from Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer Open
Supplementary Methods
Data from Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer Open
The role of mitochondrial DNA (mtDNA) mutations in cancer remains controversial. Ulcerative colitis is an inflammatory bowel disease that increases the risk of colorectal cancer and involves mitochondrial dysfunction, making it an ideal mo…
Data from Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer Open
The role of mitochondrial DNA (mtDNA) mutations in cancer remains controversial. Ulcerative colitis is an inflammatory bowel disease that increases the risk of colorectal cancer and involves mitochondrial dysfunction, making it an ideal mo…
Supplementary Data from Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon Open
Supplementary Data from Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon
Supplementary Data from Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon Open
Supplementary Data from Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon
Supplementary Figure from Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon Open
Supplementary Figure from Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon
Data from Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon Open
Although somatic mutations in colorectal cancer are well characterized, little is known about the accumulation of cancer mutations in the normal colon before cancer. Here, we have developed and applied an ultrasensitive, single-molecule mu…
Supplementary Figure from Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon Open
Supplementary Figure from Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon
Data from Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon Open
Although somatic mutations in colorectal cancer are well characterized, little is known about the accumulation of cancer mutations in the normal colon before cancer. Here, we have developed and applied an ultrasensitive, single-molecule mu…
View article: Data from Ulcerative Colitis–Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and Inflammation
Data from Ulcerative Colitis–Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and Inflammation Open
Inflammation plays a role in the progression to cancer and it is linked to the presence of senescent cells. Ulcerative colitis (UC) is a chronic inflammatory disease that predisposes to colorectal cancer. Tumorigenesis in this setting is a…
View article: Supplementary Figures 1-2, Table 1 from Ulcerative Colitis–Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and Inflammation
Supplementary Figures 1-2, Table 1 from Ulcerative Colitis–Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and Inflammation Open
Supplementary Figures 1-2, Table 1 from Ulcerative Colitis–Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and Inflammation
View article: Data from Ulcerative Colitis–Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and Inflammation
Data from Ulcerative Colitis–Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and Inflammation Open
Inflammation plays a role in the progression to cancer and it is linked to the presence of senescent cells. Ulcerative colitis (UC) is a chronic inflammatory disease that predisposes to colorectal cancer. Tumorigenesis in this setting is a…