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View article: Hepatocyte delivery of miR-34b/c reduces hepatic stellate cell activation and improves liver fibrosis
Hepatocyte delivery of miR-34b/c reduces hepatic stellate cell activation and improves liver fibrosis Open
Liver fibrosis is a major health problem worldwide and currently available treatments are only supportive. The microRNA-34 (miR-34) family is upregulated in response to chronic liver injuries, and miR-34b/c downregulates the platelet-deriv…
View article: Impact of liver fibrosis on AAV-mediated gene transfer to mouse hepatocytes
Impact of liver fibrosis on AAV-mediated gene transfer to mouse hepatocytes Open
View article: Sestrin2 drives ER-phagy in response to protein misfolding
Sestrin2 drives ER-phagy in response to protein misfolding Open
Protein biogenesis within the endoplasmic reticulum (ER) is crucial for organismal function. Errors during protein folding necessitate the removal of faulty products. ER-associated protein degradation and ER-phagy target misfolded proteins…
View article: Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis
Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis Open
Significance α1-Antitrypsin deficiency is one of the most common genetic diseases. Homozygous and heterozygous carriers of the Z allele of α1-antitrypsin are susceptible to developing liver fibrosis and cirrhosis. In mouse and human sample…
View article: Author Index
Author Index Open
View article: CHOP and c-JUN up-regulate the mutant Z α1-antitrypsin, exacerbating its aggregation and liver proteotoxicity
CHOP and c-JUN up-regulate the mutant Z α1-antitrypsin, exacerbating its aggregation and liver proteotoxicity Open
View article: CHOP-c-JUN complex plays a critical role in liver proteotoxicity induced by mutant Z alpha-1 antitrypsin
CHOP-c-JUN complex plays a critical role in liver proteotoxicity induced by mutant Z alpha-1 antitrypsin Open
Alpha-1 antitrypsin (AAT) deficiency is a common genetic disorder with lung and liver involvement. Most patients carry the Z allele in SERPINA1 that encodes a mutant AAT (ATZ) forming hepatotoxic polymers. We found CHOP upregulation and ac…
View article: Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure
Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure Open
Acute liver failure is a rapidly progressive deterioration of liver function resulting in high mortality. In experimental mouse models of acute liver failure, we found that two metabolic enzymes, namely pyruvate dehydrogenase complex and l…
View article: Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate
Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate Open
Pyruvate dehydrogenase complex (PDHC) is a key enzyme in metabolism linking glycolysis to tricarboxylic acid cycle and its activity is tightly regulated by phosphorylation catalyzed by four pyruvate dehydrogenase kinase (PDK) isoforms. PDK…