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View article: Challenges in the diagnosis and treatment of genetic cholestasis in adults
Challenges in the diagnosis and treatment of genetic cholestasis in adults Open
View article: #5 The adjustment of GFR by body surface area: a misleading procedure in trials focused on weight reduction and GFR changes
#5 The adjustment of GFR by body surface area: a misleading procedure in trials focused on weight reduction and GFR changes Open
Background and Aims controversies exist on the benefits of estimated GFR (eGFR) by formulas (more uncertain) of gold standards (more accurate). Another problem is the adjustment of GFR for body surface area (BSA). The scientific background…
View article: #119 Exercise intervention in patients with metabolic syndrome and renal disease: a prospective study (EXRED)
#119 Exercise intervention in patients with metabolic syndrome and renal disease: a prospective study (EXRED) Open
Background and Aims In patients with chronic kidney disease (CKD) of diverse causes, obesity and metabolic syndrome (MS) accelerate disease progression. Therapeutic exercise could be effective in treating obesity and MS in patients with CK…
View article: Comprehensive analysis of extracellular matrix remodelling via cyclophilin inhibition in human models of alcohol‐related liver fibrosis
Comprehensive analysis of extracellular matrix remodelling via cyclophilin inhibition in human models of alcohol‐related liver fibrosis Open
Background and Purpose Chronic liver disease and hepatic fibrosis constitute a threat to global health. Clinical translation of preclinical research has been limited, highlighting an urgent need for novel treatments. Cyclophilin inhibitors…
View article: The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT
The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT Open
Background Long-term surviving liver transplant recipients can spontaneously develop operational tolerance, which allows them to completely discontinue their immunosuppression, but we lack validated tools to predict the likelihood of rejec…
View article: British Society of Gastroenterology guidelines for diagnosis and management of autoimmune hepatitis
British Society of Gastroenterology guidelines for diagnosis and management of autoimmune hepatitis Open
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease which, if untreated, often leads to cirrhosis, liver failure and death. The last British Society of Gastroenterology (BSG) guideline for the management of AIH was published…
View article: Comparative Analysis of Proteinuria and Longitudinal Outcomes in Immune Complex Membranoproliferative Glomerulonephritis and C3 Glomerulopathy
Comparative Analysis of Proteinuria and Longitudinal Outcomes in Immune Complex Membranoproliferative Glomerulonephritis and C3 Glomerulopathy Open
Proteinuria reduction was associated with improved kidney outcomes and slower eGFR decline in both C3G and IC-MPGN.
View article: Early vs. Late Liver Allograft T-Cell Mediated Rejection: A Banff Liver Allograft Pathology a Reviewpoint
Early vs. Late Liver Allograft T-Cell Mediated Rejection: A Banff Liver Allograft Pathology a Reviewpoint Open
View article: Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression
Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression Open
The maintenance of stable allograft status in the absence of immunosuppression (IS), known as operational tolerance, can be achieved in a small proportion of liver transplant recipients, but we lack reliable tools to predict its spontaneou…
View article: High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of Paired Clinical Liver Tissue Samples from Hepatocellular Cancer and Surrounding Region
High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of Paired Clinical Liver Tissue Samples from Hepatocellular Cancer and Surrounding Region Open
The global burden of liver cancer is increasing. Timely diagnosis is important for optimising the limited available treatment options. Understanding the metabolic consequences of hepatocellular carcinoma (HCC) may lead to more effective tr…
View article: #2295 Can we detect the evolution of GFR with estimated GFR in patients with ADPKD?
#2295 Can we detect the evolution of GFR with estimated GFR in patients with ADPKD? Open
Background and Aims ADPKD affects about 10% of the patients with CKD. In the disease the formation of cysts replace normal renal parenchyma leading to renal function loss. The evolution of the disease is irregular: some patients lose renal…
View article: A different picture on liver biopsy
A different picture on liver biopsy Open
View article: Banff 2022 Liver Group Meeting report: Monitoring long-term allograft health
Banff 2022 Liver Group Meeting report: Monitoring long-term allograft health Open
The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists, and histocompatibility specialists. Presentations and discussions focused on the evalua…
View article: Validation of NIAAAm-CRP criteria to predict alcohol-associated steatohepatitis on liver histology
Validation of NIAAAm-CRP criteria to predict alcohol-associated steatohepatitis on liver histology Open
Alcohol-associated steatohepatitis (ASH) is diagnosed on liver histology but liver biopsy is not always feasible. Non-invasive diagnosis based on clinical findings has been proposed using the National Institute on Alcohol Abuse and Alcohol…
View article: Liver Elastography in Acute Liver Failure: A Pilot Study
Liver Elastography in Acute Liver Failure: A Pilot Study Open
OBJECTIVES: We aimed to assess the feasibility and reliability of sequential ultrasonographic and elastographic monitoring in acute liver failure (ALF). DESIGN: Observational study. SETTING: ALF is a rare, life-threatening disease that req…
View article: Genetic cholestasis in children and adults
Genetic cholestasis in children and adults Open
View article: Human Precision-Cut Liver Slices: A Potential Platform to Study Alcohol-Related Liver Disease
Human Precision-Cut Liver Slices: A Potential Platform to Study Alcohol-Related Liver Disease Open
Alcohol-related liver disease (ALD) encompasses a range of pathological conditions that are complex to study at the clinical and preclinical levels. Despite the global burden of ALD, there is a lack of effective treatments, and mortality i…
View article: Patient-derived precision cut tissue slices from primary liver cancer as a potential platform for preclinical drug testing
Patient-derived precision cut tissue slices from primary liver cancer as a potential platform for preclinical drug testing Open
Foundation for Liver Research, London.
View article: Sodium-glucose cotransporter 2 inhibition in primary and secondary glomerulonephritis
Sodium-glucose cotransporter 2 inhibition in primary and secondary glomerulonephritis Open
Background The role of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in the management glomerular/systemic autoimmune diseases with proteinuria in real-world clinical settings is unclear. Methods This is a retrospective, observational…
View article: #3439 EXERCISE, METABOLIC SYNDROME AND CHRONIC KIDNEY DISEASE (CKD): THE EX-RED STUDY
#3439 EXERCISE, METABOLIC SYNDROME AND CHRONIC KIDNEY DISEASE (CKD): THE EX-RED STUDY Open
Background and aims Obesity and metabolic syndrome (MS) are risk factors for renal disease progression in patients with established chronic kidney disease (CKD). Although therapeutic exercise has a potential role to treat or ameliorate chr…
View article: Data from A Combined Strategy of SAGE and Quantitative PCR Provides a 13-Gene Signature that Predicts Preoperative Chemoradiotherapy Response and Outcome in Rectal Cancer
Data from A Combined Strategy of SAGE and Quantitative PCR Provides a 13-Gene Signature that Predicts Preoperative Chemoradiotherapy Response and Outcome in Rectal Cancer Open
Purpose: Preoperative chemoradiotherapy (CRT) is the treatment of choice for rectal cancer (RC), but half of the patients do not respond, suffer unnecessary toxicities, and surgery delays. We aimed to develop a model that could pred…
View article: Data from A Combined Strategy of SAGE and Quantitative PCR Provides a 13-Gene Signature that Predicts Preoperative Chemoradiotherapy Response and Outcome in Rectal Cancer
Data from A Combined Strategy of SAGE and Quantitative PCR Provides a 13-Gene Signature that Predicts Preoperative Chemoradiotherapy Response and Outcome in Rectal Cancer Open
Purpose: Preoperative chemoradiotherapy (CRT) is the treatment of choice for rectal cancer (RC), but half of the patients do not respond, suffer unnecessary toxicities, and surgery delays. We aimed to develop a model that could pred…
View article: Supplementary Data from A Combined Strategy of SAGE and Quantitative PCR Provides a 13-Gene Signature that Predicts Preoperative Chemoradiotherapy Response and Outcome in Rectal Cancer
Supplementary Data from A Combined Strategy of SAGE and Quantitative PCR Provides a 13-Gene Signature that Predicts Preoperative Chemoradiotherapy Response and Outcome in Rectal Cancer Open
Supplementary Figures S1-S4; Supplementary Tables S1-S3.
View article: Supplementary Data from A Combined Strategy of SAGE and Quantitative PCR Provides a 13-Gene Signature that Predicts Preoperative Chemoradiotherapy Response and Outcome in Rectal Cancer
Supplementary Data from A Combined Strategy of SAGE and Quantitative PCR Provides a 13-Gene Signature that Predicts Preoperative Chemoradiotherapy Response and Outcome in Rectal Cancer Open
Supplementary Figures S1-S4; Supplementary Tables S1-S3.
View article: Clinical Profiles and Patterns of Kidney Disease Progression in C3 Glomerulopathy
Clinical Profiles and Patterns of Kidney Disease Progression in C3 Glomerulopathy Open
Key Points Kidney survival in C3 glomerulopathy is significantly higher in patients with a disease chronicity score <4 and proteinuria <3.5 g/d, regardless of baseline eGFR. A faster eGFR decline in C3 glomerulopathy is associated with hig…
View article: Banff 2022 Liver Group Meeting Report: Monitoring Long Term Allograft Health
Banff 2022 Liver Group Meeting Report: Monitoring Long Term Allograft Health Open
View article: Lysophosphatidylcholines modulate immunoregulatory checkpoints in peripheral monocytes and are associated with mortality in people with acute liver failure
Lysophosphatidylcholines modulate immunoregulatory checkpoints in peripheral monocytes and are associated with mortality in people with acute liver failure Open
View article: Low dose interleukin-2 selectively expands circulating regulatory T cells but fails to promote liver allograft tolerance in humans
Low dose interleukin-2 selectively expands circulating regulatory T cells but fails to promote liver allograft tolerance in humans Open
The administration of low-dose IL-2 is an effective way of increasing the number of circulating regulatory T cells (Tregs), an immunosuppressive lymphocyte subset that is key for the establishment of immunological tolerance, but its use to…
View article: Clinical phenotype of adult‐onset liver disease in patients with variants in ABCB4 , ABCB11 , and ATP8B1
Clinical phenotype of adult‐onset liver disease in patients with variants in ABCB4 , ABCB11 , and ATP8B1 Open
Variants in ATP8B1 , ABCB11 , and ABCB4 underlie the most prevalent forms of progressive familial intrahepatic cholestasis. We aim to describe variants in these genes in a cohort of patients with adult‐onset liver disease, and explore a ge…
View article: Human Immunocompetent Model of Neuroendocrine Liver Metastases Recapitulates Patient-Specific Tumour Microenvironment
Human Immunocompetent Model of Neuroendocrine Liver Metastases Recapitulates Patient-Specific Tumour Microenvironment Open
Neuroendocrine liver metastases (LM-NEN) develop in a considerable proportion of patients with gastroenteropancreatic neuroendocrine neoplasms. There is a paucity of experimental models that accurately recapitulate this complex metastatic …