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View article: Senotherapeutics for metabolic disease and diabetic complications
Senotherapeutics for metabolic disease and diabetic complications Open
Metabolic diseases, including obesity, Type 2 diabetes (T2D), and metabolic syndrome, are increasingly prevalent worldwide, driven by sedentary lifestyles, aging populations, and complex genetic and environmental factors. Traditionally und…
View article: Physical training reduces cell senescence and associated insulin resistance in skeletal muscle
Physical training reduces cell senescence and associated insulin resistance in skeletal muscle Open
These findings highlight the role of CS in regulating insulin sensitivity in SkM and underscore the therapeutic potential of exercise in mitigating age- and obesity-related muscle dysfunction. Targeting CS through exercise or senolytic age…
View article: Hypomethylation at <scp> <i>PANDAR</i> </scp> promoter progressively induces senescence in adipocyte precursor cells in subjects with obesity and type 2 diabetes
Hypomethylation at <span> <i>PANDAR</i> </span> promoter progressively induces senescence in adipocyte precursor cells in subjects with obesity and type 2 diabetes Open
The risk of developing type 2 diabetes (T2D) is heterogeneous among individuals with obesity. Functional decline of adipocyte precursor cells (APCs) and accumulation of senescent cells in the subcutaneous adipose tissue contributes to the …
View article: Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabetics
Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabetics Open
Background First-degree relatives of type 2 diabetics (FDR) exhibit a high risk of developing type 2 diabetes (T2D) and feature subcutaneous adipocyte hypertrophy, independent of obesity. In FDR, adipose cell abnormalities contribute to ea…
View article: The Transcription Factor HOXA5: Novel Insights into Metabolic Diseases and Adipose Tissue Dysfunction
The Transcription Factor HOXA5: Novel Insights into Metabolic Diseases and Adipose Tissue Dysfunction Open
The transcription factor HOXA5, from the HOX gene family, has long been studied due to its critical role in physiological activities in normal cells, such as organ development and body patterning, and pathological activities in cancer cell…
View article: Methylglyoxal Impairs the Pro-Angiogenic Ability of Mouse Adipose-Derived Stem Cells (mADSCs) via a Senescence-Associated Mechanism
Methylglyoxal Impairs the Pro-Angiogenic Ability of Mouse Adipose-Derived Stem Cells (mADSCs) via a Senescence-Associated Mechanism Open
Adipose-derived stem cells (ADSCs) play a crucial role in angiogenesis and repair of damaged tissues. However, in pathological conditions including diabetes, ADSC function is compromised. This work aims at evaluating the effect of Methylgl…
View article: Increased cell senescence in human metabolic disorders
Increased cell senescence in human metabolic disorders Open
Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and aging increases the burden of CS in all major metabolic tissues. However, CS is also increased in adult obesity, type 2 diabetes (T2D), and nonalcohol…
View article: Type 2 diabetes, independent of obesity and age, is characterized by senescent and dysfunctional mature human adipose cells
Type 2 diabetes, independent of obesity and age, is characterized by senescent and dysfunctional mature human adipose cells Open
Obesity with dysfunctional adipose cells is the major cause of the current epidemic of T2D. We examined senescence in human adipose tissue cells from age- and BMI-matched lean, obese and obese T2D individuals and found mature and fully dif…
View article: Type 2 diabetes, independent of obesity and age, is characterized by senescent and dysfunctional mature human adipose cells
Type 2 diabetes, independent of obesity and age, is characterized by senescent and dysfunctional mature human adipose cells Open
Obesity with dysfunctional adipose cells is the major cause of the current epidemic of T2D. We examined senescence in human adipose tissue cells from age- and BMI-matched lean, obese and obese T2D individuals and found mature and fully dif…
View article: Chronic hyperinsulinemia promotes human hepatocyte senescence
Chronic hyperinsulinemia promotes human hepatocyte senescence Open
Our findings demonstrate a direct link between chronic hyperinsulinemia and hepatocyte senescence. This effect can be blocked by reducing the levels of insulin receptors or administration of senolytic drugs, such as dasatinib and quercetin.
View article: Epigenetic Dysregulation of the Homeobox A5 (HOXA5) Gene Associates with Subcutaneous Adipocyte Hypertrophy in Human Obesity
Epigenetic Dysregulation of the Homeobox A5 (HOXA5) Gene Associates with Subcutaneous Adipocyte Hypertrophy in Human Obesity Open
Along with insulin resistance and increased risk of type 2 diabetes (T2D), lean first-degree relatives of T2D subjects (FDR) feature impaired adipogenesis in subcutaneous adipose tissue (SAT) and subcutaneous adipocyte hypertrophy well bef…
View article: <i>ZMAT3</i> hypomethylation contributes to early senescence of preadipocytes from healthy first‐degree relatives of type 2 diabetics
<i>ZMAT3</i> hypomethylation contributes to early senescence of preadipocytes from healthy first‐degree relatives of type 2 diabetics Open
Senescence of adipose precursor cells (APC) impairs adipogenesis, contributes to the age‐related subcutaneous adipose tissue (SAT) dysfunction, and increases risk of type 2 diabetes (T2D). First‐degree relatives of T2D individuals (FDR) fe…
View article: Adipocyte precursor cells from first degree relatives of type 2 diabetic patients feature changes in <i>hsa‐mir‐23a‐5p</i> , <i>‐193a‐5p</i> , and <i>‐193b‐5p</i> and insulin‐like growth factor 2 expression
Adipocyte precursor cells from first degree relatives of type 2 diabetic patients feature changes in <i>hsa‐mir‐23a‐5p</i> , <i>‐193a‐5p</i> , and <i>‐193b‐5p</i> and insulin‐like growth factor 2 expression Open
First‐degree relatives (FDRs) of type 2 diabetics (T2D) feature dysfunction of subcutaneous adipose tissue (SAT) long before T2D onset. miRNAs have a role in adipocyte precursor cells (APC) differentiation and in adipocyte identity. Thus, …
View article: Altered <i>PTPRD</i> DNA Methylation Associates with Restricted Adipogenesis in Healthy First-Degree Relatives of Type 2 Diabetes Subjects
Altered <i>PTPRD</i> DNA Methylation Associates with Restricted Adipogenesis in Healthy First-Degree Relatives of Type 2 Diabetes Subjects Open
Aim: First-degree relatives (FDR) of individuals with Type 2 diabetes (T2D) feature restricted adipogenesis, which render them more vulnerable to T2D. Epigenetics may contribute to these abnormalities. Methods: FDR pre-adipocyte Methylome …
View article: Nutritional Factors, DNA Methylation, and Risk of Type 2 Diabetes and Obesity: Perspectives and Challenges
Nutritional Factors, DNA Methylation, and Risk of Type 2 Diabetes and Obesity: Perspectives and Challenges Open
A healthy diet improves life expectancy and helps to prevent common chronic diseases such as type 2 diabetes (T2D) and obesity. The mechanisms driving these effects are not fully understood, but are likely to involve epigenetics. Epigeneti…
View article: Citrus aurantium L. dry extracts promote C/ebpβ expression and improve adipocyte differentiation in 3T3-L1 cells
Citrus aurantium L. dry extracts promote C/ebpβ expression and improve adipocyte differentiation in 3T3-L1 cells Open
Metabolic and/or endocrine dysfunction of the white adipose tissue (WAT) contribute to the development of metabolic disorders, such as Type 2 Diabetes (T2D). Therefore, the identification of products able to improve adipose tissue function…
View article: Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5
Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5 Open
Growing evidence indicates that adiposity is associated with raised cancer incidence, morbidity and mortality. In a subset of tumors, cancer cell growth and/or metastasis predominantly occur in adipocyte-rich microenvironment. Indeed, adip…
View article: IL‐3 synergises with basophil‐derived IL‐4 and IL‐13 to promote the alternative activation of human monocytes
IL‐3 synergises with basophil‐derived IL‐4 and IL‐13 to promote the alternative activation of human monocytes Open
Basophil‐derived IL‐4 is involved in the alternative activation of mouse monocytes, as recently shown in vivo. Whether this applies to human basophils and monocytes has not been established yet. Here, we sought to characterise the interact…