Rosaleena Mohanty
YOU?
Author Swipe
View article: Brain patterns and risk factors in the FINGER RCT multimodal lifestyle intervention
Brain patterns and risk factors in the FINGER RCT multimodal lifestyle intervention Open
View article: Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70-year-olds
Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70-year-olds Open
View article: Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease
Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease Open
The link between regional tau load and clinical manifestation of Alzheimer’s disease (AD) highlights the importance of characterizing spatial tau distribution across disease variants. In typical (memory-predominant) AD, the spatial progres…
View article: Atrophy trajectories in Alzheimer’s disease: how sex matters
Atrophy trajectories in Alzheimer’s disease: how sex matters Open
Introduction Longitudinal subtypes in Alzheimer’s disease (AD) have been identified based on their distinct brain atrophy trajectories, encompassing mediotemporal and cortical pathways. These subtypes include minimal atrophy, limbic predom…
View article: Lower Network Functional Connectivity Is Associated With Higher Regional Tau Burden Among Those At-Risk of Alzheimer’s Disease But Cognitively Unimpaired: Specific Patterns Based on Amyloid Status
Lower Network Functional Connectivity Is Associated With Higher Regional Tau Burden Among Those At-Risk of Alzheimer’s Disease But Cognitively Unimpaired: Specific Patterns Based on Amyloid Status Open
View article: Biological signatures in the Alzheimer’s continuum discriminate between diagnosis-related and -unrelated associations to ATN categories
Biological signatures in the Alzheimer’s continuum discriminate between diagnosis-related and -unrelated associations to ATN categories Open
Alzheimer’s disease and related dementias have a multifactorial aetiology and heterogeneous biology. The current study aims to identify different biological signatures in a deeply phenotyped memory clinic patient population. In this cross-…
View article: Biological brain age and resilience in cognitively unimpaired 70‐year‐old individuals
Biological brain age and resilience in cognitively unimpaired 70‐year‐old individuals Open
INTRODUCTION This study investigated the associations of brain age gap (BAG)—a biological marker of brain resilience—with life exposures, neuroimaging measures, biological processes, and cognitive function. METHODS We derived BAG by subtra…
View article: Distinct cerebrovascular pathways underlying Alzheimer’s disease‐related neurodegeneration
Distinct cerebrovascular pathways underlying Alzheimer’s disease‐related neurodegeneration Open
Background Cerebrovascular pathology is an emerging key contributor to neurodegeneration in both non‐pathological and pathological aging. Cerebrovascular pathology manifests as different markers in the brain (gross‐ vs micro‐infarcts, chro…
View article: Longitudinal cortical atrophy in cases of AT concordance and discordance
Longitudinal cortical atrophy in cases of AT concordance and discordance Open
Background Although ß‐amyloid and tau PET positivity (A+T+) has been related to neurodegeneration and cognitive decline in Alzheimer’s disease (AD), the driving force of neurodegeneration in discordant AT cases remains controversial. We in…
View article: Longitudinal cortical atrophy in cases of AT concordance and discordance
Longitudinal cortical atrophy in cases of AT concordance and discordance Open
Background Although β‐amyloid and tau PET positivity (A+T+) has been related to neurodegeneration and cognitive decline in Alzheimer’s disease (AD), the driving force of neurodegeneration in discordant AT cases remains controversial. We in…
View article: Risk and protective factors associated with grey matter patterns in older adults
Risk and protective factors associated with grey matter patterns in older adults Open
INTRODUCTION Early dementia detection in the general population is challenged by high cerebral grey matter (GM) heterogeneity preceding behavioural symptoms. Here, we identify distinct GM patterns and their associated factors in a populati…
View article: MRI subtypes in Parkinson’s disease across diverse populations and clustering approaches
MRI subtypes in Parkinson’s disease across diverse populations and clustering approaches Open
Parkinson’s disease (PD) is clinically heterogeneous, which suggests the existence of subtypes; however, there has been no consensus regarding their characteristics. This study included 633 PD individuals across distinct cohorts: unmedicat…
View article: Divergent Neurodegenerative Patterns: Comparison of FDG-PET- and MRI-based Alzheimer’s Disease Subtypes
Divergent Neurodegenerative Patterns: Comparison of FDG-PET- and MRI-based Alzheimer’s Disease Subtypes Open
[18F] fluorodeoxyglucose (FDG)-PET and MRI are key imaging markers for neurodegeneration in Alzheimer's disease. It is well-established that parieto-temporal hypometabolism on FDG-PET is closely associated with medial temporal a…
View article: Multi-pathological contributions toward atrophy patterns in the Alzheimer’s disease continuum
Multi-pathological contributions toward atrophy patterns in the Alzheimer’s disease continuum Open
Introduction Heterogeneity in downstream atrophy in Alzheimer’s disease (AD) is predominantly investigated in relation to pathological hallmarks (Aβ, tau) and co-pathologies (cerebrovascular burden) independently. However, the proportional…
View article: MRI subtypes in Parkinson’s disease:Unraveling differences across diverse populations and clustering approaches
MRI subtypes in Parkinson’s disease:Unraveling differences across diverse populations and clustering approaches Open
Parkinson’s disease (PD) is clinically heterogeneous, which suggests the existence of subtypes; however, there has been no consensus regarding their characteristics. This study included 633 PD individuals across distinct cohorts: unmedicat…
View article: Vascular contributions towards atrophy-based subtypes of Alzheimer's disease
Vascular contributions towards atrophy-based subtypes of Alzheimer's disease Open
Introduction: Heterogeneity in downstream atrophy is predominantly investigated in relation to pathological hallmarks (Aβ, tau) while the contribution of vascular pathology remains unclear in Alzheimer's disease (AD). We assessed heterogen…
View article: Divergent neurodegenerative patterns: Comparison of [18F] fluorodeoxyglucose-PET- and MRI-based Alzheimer’s disease subtypes
Divergent neurodegenerative patterns: Comparison of [18F] fluorodeoxyglucose-PET- and MRI-based Alzheimer’s disease subtypes Open
[18F] fluorodeoxyglucose (FDG)-PET and MRI are key imaging markers for neurodegeneration in Alzheimer’s disease. It has been well established that parieto-temporal hypometabolism on FDG-PET is closely associated with medial temporal atroph…
View article: The impact of sex on the progression of AD atrophy‐based subtypes
The impact of sex on the progression of AD atrophy‐based subtypes Open
Background Recently, longitudinal subtypes in AD have been identified based on their different brain atrophy trajectories (Poulakis et al. 2022 Nat Commun), which follow either mediotemporal or cortical pathways. The mediotemporal pathway,…
View article: Predicting amyloid-PET status in a memory clinic: The role of the novel antero-posterior index and visual rating scales
Predicting amyloid-PET status in a memory clinic: The role of the novel antero-posterior index and visual rating scales Open
Our study emphasizes the significance of visual rating scales in predicting amyloid-PET positivity within a real-world memory clinic. Implementing the novel API scale, alongside our cohort-based MTA and PA thresholds, has the potential to …
View article: Correction: Differential response to donepezil in MRI subtypes of mild cognitive impairment
Correction: Differential response to donepezil in MRI subtypes of mild cognitive impairment Open
View article: Differential response to donepezil in MRI subtypes of mild cognitive impairment
Differential response to donepezil in MRI subtypes of mild cognitive impairment Open
View article: Neuropathological features of antemortem atrophy‐based subtypes of Alzheimer’s disease
Neuropathological features of antemortem atrophy‐based subtypes of Alzheimer’s disease Open
Background Pure Alzheimer’s disease (AD), characterized by combined amyloid and tau pathology, is not the most prevalent form of the disease as non‐AD pathologies (e.g., alpha‐synuclein and TDP‐43) are commonly observed postmortem. The rol…
View article: Correction: Associations between different tau‑PET patterns and longitudinal atrophy in the Alzheimer’s disease continuum: biological and methodological perspectives from disease heterogeneity
Correction: Associations between different tau‑PET patterns and longitudinal atrophy in the Alzheimer’s disease continuum: biological and methodological perspectives from disease heterogeneity Open
View article: Associations between different tau-PET patterns and longitudinal atrophy in the Alzheimer’s disease continuum: biological and methodological perspectives from disease heterogeneity
Associations between different tau-PET patterns and longitudinal atrophy in the Alzheimer’s disease continuum: biological and methodological perspectives from disease heterogeneity Open
View article: MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies
MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies Open
View article: Differential response to Donepezil in MRI subtypes of mild cognitive impairment
Differential response to Donepezil in MRI subtypes of mild cognitive impairment Open
Background Donepezil is an approved therapy for the treatment of Alzheimer’s disease (AD). Results across clinical trials have been inconsistent, which may be explained by design-methodological issues, the pathophysiological heterogeneity …
View article: Genetic and environmental influence on resting state networks in young male and female adults: a cartographer mapping study
Genetic and environmental influence on resting state networks in young male and female adults: a cartographer mapping study Open
We propose a unique, minimal assumption, approach based on variance analyses (compared with standard approaches) to investigate genetic influence on individual differences on the functional connectivity of the brain using 65 monozygotic an…
View article: Heterogeneity in normal aging: longitudinal trajectories of grey matter
Heterogeneity in normal aging: longitudinal trajectories of grey matter Open
Background In dementia research, the role of aging is usually de‐trended as a confounder, implying implicit assumptions on the nature of controls. In fact, normal aging brings about structural and functional damage, possibly reflecting bra…
View article: Perioperative ischaemic brain injury and plasma neurofilament light: a secondary analysis of two prospective cohort studies
Perioperative ischaemic brain injury and plasma neurofilament light: a secondary analysis of two prospective cohort studies Open
View article: The hippocampal sparing subtype of Alzheimer’s disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review
The hippocampal sparing subtype of Alzheimer’s disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review Open