Rosalind L. Jeffree
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List of Contributors Open
View article: QLTI-18. Feasibility of capturing clinical quality indicators in high-grade glioma and alignment with guideline-recommended care
QLTI-18. Feasibility of capturing clinical quality indicators in high-grade glioma and alignment with guideline-recommended care Open
PURPOSE In 2022, 58 Clinical Quality Indicators (CQIs) covering key aspects of glioma care were developed for an Australian brain cancer registry via a Delphi process [1]. Evidence supports MDT-managed patients have higher concordance with…
View article: EXTH-76. Validating the Eph family of receptors as therapeutic targets using patient-derived Glioblastoma organoids
EXTH-76. Validating the Eph family of receptors as therapeutic targets using patient-derived Glioblastoma organoids Open
The failure of current glioblastoma therapies is largely attributed to an incomplete understanding of the tumor’s inherent plasticity, a key driver of treatment resistance. Better preclinical models that possess intra-tumoral heterogeneity…
View article: Computed Tomography and Magnetic Resonance Imaging Findings in Early Glioblastoma (e-GBM): Spotting the Wolf in Sheep’s Clothing
Computed Tomography and Magnetic Resonance Imaging Findings in Early Glioblastoma (e-GBM): Spotting the Wolf in Sheep’s Clothing Open
View article: Harnessing the innate immune system for glioblastoma therapeutics
Harnessing the innate immune system for glioblastoma therapeutics Open
Glioblastoma is the most common primary malignant brain cancer and is associated with significant mortality and resistance to treatment. One of the major barriers to successful treatment of this cancer is the highly immunosuppressive tumou…
View article: Spontaneous resorption of herniated lumbar discs: illustrative cases
Spontaneous resorption of herniated lumbar discs: illustrative cases Open
BACKGROUND It is well recognized that symptoms of lumbar disc herniation often improve with conservative management. It is less well understood that the disc herniation resolves over time. OBSERVATIONS The authors present several cases dem…
View article: Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage: Protocol for an international, phase 3, randomised, placebo-controlled, multicentre trial
Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage: Protocol for an international, phase 3, randomised, placebo-controlled, multicentre trial Open
View article: A unique case of extra-cerebral diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters
A unique case of extra-cerebral diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters Open
Diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (DGONC) is a newly recognized provisional entity in the fifth edition of the WHO Classification of Central Nervous System Tumors, typically found in pedia…
View article: How I Do Laparoscopic Insertion of the Peritoneal Catheter in a Ventriculoperitoneal Shunt
How I Do Laparoscopic Insertion of the Peritoneal Catheter in a Ventriculoperitoneal Shunt Open
View article: Defining benchmark outcomes for mesial temporal lobe epilepsy surgery: A global multicenter analysis of 1119 cases
Defining benchmark outcomes for mesial temporal lobe epilepsy surgery: A global multicenter analysis of 1119 cases Open
Objective Benchmarking has been proposed to reflect surgical quality and represents the highest standard reference values for desirable results. We sought to determine benchmark outcomes in patients after surgery for drug‐resistant mesial …
View article: Local hero: A phase II study of local therapy only (stereotactic radiosurgery and / or surgery) for treatment of up to five brain metastases from HER2+ breast cancer. (TROG study 16.02)
Local hero: A phase II study of local therapy only (stereotactic radiosurgery and / or surgery) for treatment of up to five brain metastases from HER2+ breast cancer. (TROG study 16.02) Open
Introduction, A decade ago, stereotactic radiosurgery (SRS) without whole brain radiotherapy (WBRT) was emerging as preferred treatment for oligometastatic brain metastases. Studies of cavity SRS after neurosurgery were underway. Data spec…
View article: PRECISION-TBI: a study protocol for a vanguard prospective cohort study to enhance understanding and management of moderate to severe traumatic brain injury in Australia
PRECISION-TBI: a study protocol for a vanguard prospective cohort study to enhance understanding and management of moderate to severe traumatic brain injury in Australia Open
Introduction Traumatic brain injury (TBI) is a heterogeneous condition in terms of pathophysiology and clinical course. Outcomes from moderate to severe TBI (msTBI) remain poor despite concerted research efforts. The heterogeneity of clini…
View article: BP132 LOCAL HERO: A PHASE II STUDY OF LOCAL THERAPY ONLY (STEREOTACTIC RADIOSURGERY AND/OR SURGERY) FOR TREATMENT OF UP TO 5 BRAIN METASTASES FROM HER2+ BREAST CANCER. (TROG STUDY 16.02)
BP132 LOCAL HERO: A PHASE II STUDY OF LOCAL THERAPY ONLY (STEREOTACTIC RADIOSURGERY AND/OR SURGERY) FOR TREATMENT OF UP TO 5 BRAIN METASTASES FROM HER2+ BREAST CANCER. (TROG STUDY 16.02) Open
View article: Management Paradigm of Central Nervous System Metastases in NSCLC: An Australian Perspective
Management Paradigm of Central Nervous System Metastases in NSCLC: An Australian Perspective Open
View article: Relationships between reading performance and regional spontaneous brain activity following surgical removal of primary left-hemisphere tumors: A resting-state fMRI study
Relationships between reading performance and regional spontaneous brain activity following surgical removal of primary left-hemisphere tumors: A resting-state fMRI study Open
Left-hemisphere intraparenchymal primary brain tumor patients are at risk of developing reading difficulties that may be stable, improve or deteriorate after surgery. Previous studies examining language organization in brain tumor patients…
View article: Proteome profiling of salivary small extracellular vesicles in glioblastoma patients
Proteome profiling of salivary small extracellular vesicles in glioblastoma patients Open
Background Extracellular vesicles (EVs) play a critical role in intercellular communication under physiological and pathological conditions, including cancer. EVs cargo reflects their cell of origin, suggesting their utility as biomarkers.…
View article: A pilot study: Metabolic profiling of plasma and saliva samples from newly diagnosed glioblastoma patients
A pilot study: Metabolic profiling of plasma and saliva samples from newly diagnosed glioblastoma patients Open
Background Despite aggressive treatment, more than 90% of glioblastoma (GBM) patients experience recurrences. GBM response to therapy is currently assessed by imaging techniques and tissue biopsy. However, difficulties with these methods m…
View article: Muscle and Its Neuromuscular Synapse – Players in the Pathogenesis of Motor Neuron Disease
Muscle and Its Neuromuscular Synapse – Players in the Pathogenesis of Motor Neuron Disease Open
View article: High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons
High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons Open
Dendritic spikes function as cardinal components of rodent neocortical circuit computations. Recently, the biophysical properties of human pyramidal neurons (PNs) have been reported to be divergent, raising the question of whether dendriti…
View article: Multi-Arm GlioblastoMa Australasia (MAGMA): protocol for a multiarm randomised clinical trial for people affected by glioblastoma
Multi-Arm GlioblastoMa Australasia (MAGMA): protocol for a multiarm randomised clinical trial for people affected by glioblastoma Open
Introduction Glioblastoma (GBM) is the most common malignant primary central nervous system cancer in adults. The objective of the Multi-Arm GlioblastoMa Australasia (MAGMA) trial is to test hypotheses in real world setting to improve surv…
View article: Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease
Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease Open
A central event in the pathogenesis of motor neuron disease (MND) is the loss of neuromuscular junctions (NMJs), yet the mechanisms that lead to this event in MND remain to be fully elucidated. Maintenance of the NMJ relies upon neural agr…
View article: High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons
High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons Open
Dendritic computations have a central role in rodent neocortical circuit function, which are signaled into neuronal output by the initiation and propagation of regenerative dendritic spikes. However, it remains poorly explored whether thes…
View article: High-Fidelity Dendritic Sodium Spike Generation in Human Layer 2/3 Neocortical Pyramidal Neurons
High-Fidelity Dendritic Sodium Spike Generation in Human Layer 2/3 Neocortical Pyramidal Neurons Open
View article: Enhancing Safety in Epilepsy Surgery (EASINESS): Study Protocol for a Retrospective, Multicenter, Open Registry
Enhancing Safety in Epilepsy Surgery (EASINESS): Study Protocol for a Retrospective, Multicenter, Open Registry Open
Introduction: Optimizing patient safety and quality improvement is increasingly important in surgery. Benchmarks and clinical quality registries are being developed to assess the best achievable results for several surgical procedures and …
View article: LUMOS - Low and Intermediate Grade Glioma Umbrella Study of Molecular Guided TherapieS at relapse: Protocol for a pilot study
LUMOS - Low and Intermediate Grade Glioma Umbrella Study of Molecular Guided TherapieS at relapse: Protocol for a pilot study Open
Introduction Grades 2 and 3 gliomas (G2/3 gliomas), when combined, are the second largest group of malignant brain tumours in adults. The outcomes for G2/3 gliomas at progression approach the dismal outcomes for glioblastoma (GBM), yet the…
View article: RTID-05. THE MULTI-ARM GLIOBLASTOMA AUSTRALASIA (MAGMA) TRIAL
RTID-05. THE MULTI-ARM GLIOBLASTOMA AUSTRALASIA (MAGMA) TRIAL Open
BACKGROUND Survival outcomes for patients with newly diagnosed glioblastoma have not changed significantly since the introduction of concurrent temozolomide with post-surgical radiation followed by adjuvant temozolomide. METHODS Multi-Arm …
View article: INNV-08. LOW AND INTERMEDIATE GRADE GLIOMA UMBRELLA STUDY OF MOLECULAR GUIDED THERAPIES (LUMOS) STUDY
INNV-08. LOW AND INTERMEDIATE GRADE GLIOMA UMBRELLA STUDY OF MOLECULAR GUIDED THERAPIES (LUMOS) STUDY Open
BACKGROUND Grade 2 and 3 (G2/3) gliomas are the second largest group of brain tumors in adults. Although the prognosis for G2/3 gliomas at the time of relapse mirror those of glioblastoma, there are few trials in this space. METHODS LUMOS …
View article: Fully automated delineation of the optic radiation for surgical planning using clinically feasible sequences
Fully automated delineation of the optic radiation for surgical planning using clinically feasible sequences Open
Quadrantanopia caused by inadvertent severing of Meyer's Loop of the optic radiation is a well‐recognised complication of temporal lobectomy for conditions such as epilepsy. Dissection studies indicate that the anterior extent of Meyer's L…
View article: What matters for people with brain cancer? Selecting clinical quality indicators for an Australian Brain Cancer Registry
What matters for people with brain cancer? Selecting clinical quality indicators for an Australian Brain Cancer Registry Open
Background The goal of a clinical quality registry is to deliver immediate gains in survival and quality of life by delivering timely feedback to practitioners, thereby ensuring every patient receives the best existing treatment. We are de…
View article: Abstract 584: Circulating tumor cells as prognostic biomarkers in glioblastoma
Abstract 584: Circulating tumor cells as prognostic biomarkers in glioblastoma Open
Background: Glioblastoma (GBM) is the most common and aggressive type of tumor arising from the central nervous system. GBM remains an incurable disease despite current advancement in therapies, with survival rates of approximately 15 mont…