Rosario Pivonello
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View article: Impact of GH and IGF-I excess on nervous and vascular retinal structure in newly diagnosed acromegaly patients
Impact of GH and IGF-I excess on nervous and vascular retinal structure in newly diagnosed acromegaly patients Open
View article: The impact of chemical pollution and warming on male fertility: a narrative review by the Special Interest Group “Environment and Fertility” of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR)
The impact of chemical pollution and warming on male fertility: a narrative review by the Special Interest Group “Environment and Fertility” of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) Open
Environmental changes are a growing global concern, and their impact on reproductive health remains incompletely understood. In this narrative review, conducted on behalf of the Italian Society of Fertility and Sterility and Reproductive M…
View article: Osilodrostat dose impact on efficacy/safety in Cushing's disease: large, pooled analysis of LINC 2, 3, and 4
Osilodrostat dose impact on efficacy/safety in Cushing's disease: large, pooled analysis of LINC 2, 3, and 4 Open
Objectives Evaluate how osilodrostat dose and baseline mean urinary free cortisol (mUFC) affect treatment outcomes and provide evidence-based guidance on personalized medical treatment for patients with Cushing's disease. Methods/design In…
View article: SUN-405 Crinecerfont Shows Favorable Trends in Improving Weight-Related Outcomes in Adults With Classic Congenital Adrenal Hyperplasia: 1-Year Results From the CAHtalyst™ Adult Study
SUN-405 Crinecerfont Shows Favorable Trends in Improving Weight-Related Outcomes in Adults With Classic Congenital Adrenal Hyperplasia: 1-Year Results From the CAHtalyst™ Adult Study Open
Disclosure: I. Bancos: None. H. Falhammar: None. J. Young: None. R. Pivonello: Received research funding from Corcept Therapeutics, Neurocrine Biosciences, Recordati AG, Spruce Bioscience and Xeris Pharmaceuticals (Strongbridge Biopharma),…
View article: MON-088 Effects Of Relacorilant On Pituitary Tumor Volume In Patients With Cushing Disease: Results From The Phase 3 Grace Study
MON-088 Effects Of Relacorilant On Pituitary Tumor Volume In Patients With Cushing Disease: Results From The Phase 3 Grace Study Open
Disclosure: G.A. Dobri: Camurus, Recordati Rare Diseases, Xeris. G. Arnaldi: Recordati Rare Diseases and HRA Pharma. R.J. Auchus: Neurocrine Biosciences/Neurocrine UK, LTD, Spruce Biosciences, Corcept Therapeutics Incorporated, Crinetics P…
View article: OR12-08 Safety and Efficacy of Once-Daily Osilodrostat in Cushing’s Syndrome to Improve Cortisol Circadian Rhythm and Quality of Life: A Multi-Center Study
OR12-08 Safety and Efficacy of Once-Daily Osilodrostat in Cushing’s Syndrome to Improve Cortisol Circadian Rhythm and Quality of Life: A Multi-Center Study Open
Disclosure: A.M. Isidori: Neurocrine, HRA Pharma, Corcept, Recordati Rare Diseases. D. Ferrari: None. I. Bonaventura: None. A. Tomaselli: None. C. Simeoli: None. L. Vincenzi: None. D. De Alcubierre: None. L. Cerroni: None. N. Di Paola: Non…
View article: OC51 - Effects of modified release hydrocortisone on reproductive function in males with congenital adrenal hyperplasia. Insights from CALLIOPE: a multicenter, prospective study
OC51 - Effects of modified release hydrocortisone on reproductive function in males with congenital adrenal hyperplasia. Insights from CALLIOPE: a multicenter, prospective study Open
Background/Introduction Patients with congenital adrenal hyperplasia (CAH) frequently experience impaired reproductive function, including altered spermatogenesis and the development of Testicular Adrenal Rest Tumors (TARTs). Modified-rele…
View article: Arterial Hypertension Under the Knife: The Promise of Adrenalectomy in MACS—Breaking News From the CHIRACIC Study
Arterial Hypertension Under the Knife: The Promise of Adrenalectomy in MACS—Breaking News From the CHIRACIC Study Open
View article: The management of adrenocortical carcinoma in the era of precision medicine
The management of adrenocortical carcinoma in the era of precision medicine Open
Adrenocortical carcinoma (ACC) is a rare but highly aggressive malignancy of the adrenal cortex, with heterogeneous clinical behaviour and limited therapeutic efficacy in advanced disease. While surgical resection remains the mainstay of c…
View article: Cabergoline counteracts adipose and skeletal muscle lipid accumulation: A novel therapeutic approach to obesity?
Cabergoline counteracts adipose and skeletal muscle lipid accumulation: A novel therapeutic approach to obesity? Open
The current preclinical study demonstrated that chronic treatment with CAB improves obesity-associated metabolic disorders such as dyslipidemia and hyperinsulinemia, by regulating the expression of lipid accumulation markers and reducing s…
View article: miR-375 Regulation of SSTR2 Expression in Corticotroph Pituitary Cells: Somatostatin Receptor Ligands Effects
miR-375 Regulation of SSTR2 Expression in Corticotroph Pituitary Cells: Somatostatin Receptor Ligands Effects Open
Long-term exposure to glucocorticoids (GCs) downregulates SSTR2 expression in corticotroph tumors, limiting the efficacy of octreotide (OCT) in the treatment of Cushing disease (CD). In AtT20 cells, dexamethasone (DEX) increased the expres…
View article: PER2 expression and cellular localization play a critical role in tumor aggressiveness and drug resistance in an <i>in vitro</i> model of hepatocellular carcinoma
PER2 expression and cellular localization play a critical role in tumor aggressiveness and drug resistance in an <i>in vitro</i> model of hepatocellular carcinoma Open
Aim: The current in vitro study investigated the role of Period 2 (PER2) in aggressiveness and the acquisition of drug resistance in hepatocellular carcinoma (HCC). Methods: Parental PLC/PRF/5 cells, along with everolimus-resistant (EveR) …
View article: Correction to: Osilodrostat improves blood pressure and glycemic control in patients with Cushing’s disease: a pooled analysis of LINC 3 and LINC 4 studies
Correction to: Osilodrostat improves blood pressure and glycemic control in patients with Cushing’s disease: a pooled analysis of LINC 3 and LINC 4 studies Open
View article: EFFECT OF ANTI-ANDROGEN MEDICATIONS ON HORMONAL PARAMETERS IN PEOPLE ASSIGNED MALE AT BIRTH
EFFECT OF ANTI-ANDROGEN MEDICATIONS ON HORMONAL PARAMETERS IN PEOPLE ASSIGNED MALE AT BIRTH Open
Objectives Gender Affirming Hormonal Therapy(GAHT) in transgender people Assigned Male at Birth(AMAB) consists of estrogen and an androgen-lowering medication, including cyproterone acetate(CPA), spironolactone, according to guidelines. Th…
View article: EFFECT OF DIFFERENT TESTOSTERONE FORMULATIONS FOR GENDER AFFIRMING HORMONAL THERAPY ON MENSTRUAL PATTERN IN PEOPLE ASSIGNED FEMALE AT BIRTH
EFFECT OF DIFFERENT TESTOSTERONE FORMULATIONS FOR GENDER AFFIRMING HORMONAL THERAPY ON MENSTRUAL PATTERN IN PEOPLE ASSIGNED FEMALE AT BIRTH Open
Objectives Menstrual dysphoria is defined as a condition of distress or anxiety due to the persistence of menstrual cycles during Gender Affirming Hormonal Therapy(GAHT)in transgender people Assigned Female at Birth(AFAB), associated with …
View article: METABOLIC, HORMONAL AND SEXUAL PROFILE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME BEFORE AND AFTER A SIX-MONTH TREATMENT WITH METFORMIN
METABOLIC, HORMONAL AND SEXUAL PROFILE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME BEFORE AND AFTER A SIX-MONTH TREATMENT WITH METFORMIN Open
Objectives The current study evaluated the effect of a six-month treatment with metformin on metabolic and hormonal profile, and on sexual and psychological function, in women with Polycystic Ovary Syndrome(PCOS). Methods Seventy-eight wom…
View article: GONADIS NATIONAL REGISTRY ON GONADAL STATUS IN PITUITARY AND ADRENAL DISORDERS: PREVALENCE AND CHARACTERIZATION OF SEXUAL DYSFUNCTIONS IN MALE PATIENTS WITH HYPERPROLACTINEMIA – AN UPDATE OF STUDY RES
GONADIS NATIONAL REGISTRY ON GONADAL STATUS IN PITUITARY AND ADRENAL DISORDERS: PREVALENCE AND CHARACTERIZATION OF SEXUAL DYSFUNCTIONS IN MALE PATIENTS WITH HYPERPROLACTINEMIA – AN UPDATE OF STUDY RES Open
Objectives Hyperprolactinemia is accompanied by sexual dysfunctions, namely decreased libido, and erectile and ejaculatory disorders and cabergoline (CAB) is known to influence sexual function; moreover, hypoprolactinemia is accompanied by…
View article: Chronotherapy With Once-Daily Osilodrostat Improves Cortisol Rhythm, Quality of Life, and Sleep in Cushing's Syndrome
Chronotherapy With Once-Daily Osilodrostat Improves Cortisol Rhythm, Quality of Life, and Sleep in Cushing's Syndrome Open
Context Medical therapy for Cushing syndrome (CS) typically aims to reduce daily cortisol output without addressing circadian rhythm restoration. No licensed drugs target this goal. Objective We investigated the efficacy and safety of time…
View article: Effects of Chrono-Exercise and Chrono-Nutrition on Muscle Health: Understanding the Molecular Mechanisms Activated by Timed Exercise and Consumption of Proteins and Carbohydrates
Effects of Chrono-Exercise and Chrono-Nutrition on Muscle Health: Understanding the Molecular Mechanisms Activated by Timed Exercise and Consumption of Proteins and Carbohydrates Open
The circadian clock is an endogenous timekeeping system that regulates various physiological and behavioral processes. Recently, it has been shown that the timing of physical activity and food intake can significantly influence metabolic m…
View article: The Management of Adrenocortical Carcinomas in The Era of Precision Medicine
The Management of Adrenocortical Carcinomas in The Era of Precision Medicine Open
Adrenocortical carcinomas (ACCs) are rare adrenal tumors that occur in hereditary syndromes or sporadically. Even in sporadic cases, somatic alterations in known susceptibility genes are often detected, emphasizing the growing role of geno…
View article: Diabetes mellitus, vaginal microbiome and sexual function: Outcomes in postmenopausal women
Diabetes mellitus, vaginal microbiome and sexual function: Outcomes in postmenopausal women Open
Diabetes mellitus is a chronic disease and a public health challenge worldwide, associated with numerous complications, including genitourinary infections and sexual dysfunction in women, particularly in menopause. The vaginal microbiome, …
View article: Osilodrostat improves blood pressure and glycemic control in patients with Cushing’s disease: a pooled analysis of LINC 3 and LINC 4 studies
Osilodrostat improves blood pressure and glycemic control in patients with Cushing’s disease: a pooled analysis of LINC 3 and LINC 4 studies Open
Purpose To evaluate the effect of osilodrostat and hypercortisolism control on blood pressure (BP) and glycemic control in patients with Cushing’s disease. Methods Pooled analysis of two Phase III osilodrostat studies (LINC 3 and LINC 4), …
View article: Integrated strategies for type 2 diabetes prevention: The role of diet and exercise
Integrated strategies for type 2 diabetes prevention: The role of diet and exercise Open
A combination of dietary modification and physical activity, particularly Mediterranean and plant-based diets coupled with combined aerobic and resistance exercise, appears to be the most effective strategy for the prevention and managemen…
View article: A Review on Mitotane: A Target Therapy in Adrenocortical Carcinoma
A Review on Mitotane: A Target Therapy in Adrenocortical Carcinoma Open
Adrenocortical carcinomas (ACCs) are rare and aggressive malignancies of adrenal cortex, associated with largely unknown mechanisms of biological development and poor prognosis. Currently, mitotane is the sole approved drug for treating ad…
View article: Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-level analysis from a multicentre clinical trial
Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-level analysis from a multicentre clinical trial Open
The research leading to these results has received funding from the European Union in the context of the National Recovery and Resilience Plan, Investment PE8 - Project Age-It: "Ageing Well in an Ageing Society". This resource was co-finan…
View article: Women With Congenital Adrenal Hyperplasia Have Favorable Pregnancy Outcomes but Prolonged Time to Conceive
Women With Congenital Adrenal Hyperplasia Have Favorable Pregnancy Outcomes but Prolonged Time to Conceive Open
Objective To study pregnancy outcomes and complications in women with congenital adrenal hyperplasia (CAH). Methods A retrospective multicenter study was conducted at tertiary reference centers in 5 countries (Austria, Germany, Italy, Swed…
View article: The Relationship Between Serum Growth Hormone, Seminal Plasma Growth Hormone, and Sperm Parameters in Patients with Acromegaly in Remission
The Relationship Between Serum Growth Hormone, Seminal Plasma Growth Hormone, and Sperm Parameters in Patients with Acromegaly in Remission Open
Objective: The influence of serum insulin-like growth factor-1 (IGF-1) and growth hormone (GH) on sperm parameters has been previously described in patients with acromegaly. However, the relationship between local GH/IGF-1 with systemic le…
View article: Who and how to screen for endogenous hypercortisolism in patients with mood disorders
Who and how to screen for endogenous hypercortisolism in patients with mood disorders Open
View article: Improved Clinical Outcomes During Long-term Osilodrostat Treatment of Cushing Disease With Normalization of Late-night Salivary Cortisol and Urinary Free Cortisol
Improved Clinical Outcomes During Long-term Osilodrostat Treatment of Cushing Disease With Normalization of Late-night Salivary Cortisol and Urinary Free Cortisol Open
Purpose To assess whether simultaneous normalization of late-night salivary cortisol (LNSC) and mean urinary free cortisol (mUFC) in patients with Cushing disease treated with osilodrostat is associated with better clinical outcomes than c…
View article: 9323 Open-label Results From Grace, A Phase 3 Double-blind, Randomized-withdrawal Study Of The Selective Glucocorticoid Receptor Modulator Relacorilant For The Treatment Of Endogenous Hypercortisolism (Cushing Syndrome)
9323 Open-label Results From Grace, A Phase 3 Double-blind, Randomized-withdrawal Study Of The Selective Glucocorticoid Receptor Modulator Relacorilant For The Treatment Of Endogenous Hypercortisolism (Cushing Syndrome) Open
Disclosure: R. Pivonello: Consulting Fee; Self; Corcept Therapeutics, Recordati AG, Crinetics Pharmaceuticals, H. Lundbeck A/S. Other; Self; Corcept- Research Funding, Neurocrine Biosciences- Research Funding, Recordati AG- Research Fundin…