Rose Hayeshi
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View article: Is Africa ready to bring to market its own medicines? A focus on GLP preclinical drug development
Is Africa ready to bring to market its own medicines? A focus on GLP preclinical drug development Open
Enhancing Africa's readiness in terms of preclinical drug development is crucial for addressing healthcare needs and advancing pharmaceutical innovation on the continent. The process of bringing new medicines to market in Africa hinges on …
View article: Phytochemical profiling and in silico prediction of interactions between Artemisia afra Jacq. ex-Wild, Catharanthus roseus (L.) G. Don and CYP2B6 enzyme
Phytochemical profiling and in silico prediction of interactions between Artemisia afra Jacq. ex-Wild, Catharanthus roseus (L.) G. Don and CYP2B6 enzyme Open
Understanding herb-drug interactions is important due to the increasing use of herbal medicines alongside conventional drugs. These interactions can alter the pharmacokinetic properties of drugs, potentially causing subtherapeutic effects …
View article: Chemical composition and antifertility effect of a South African herbal mixture in female Sprague-Dawley rats
Chemical composition and antifertility effect of a South African herbal mixture in female Sprague-Dawley rats Open
Herbal contraceptives are often considered as an affordable and accessible option for birth control practice. This study evaluated the antifertility activity of a South African herbal mixture made from three plants (Helichrysum caespititiu…
View article: Utilisation of medicinal plants for their antifertility activities: A bibliometric analysis of research endeavours from 1968 to 2023
Utilisation of medicinal plants for their antifertility activities: A bibliometric analysis of research endeavours from 1968 to 2023 Open
Background: The exponential expansion of the population, in conjunction with the escalating negative side effects associated with synthetic contraceptives, has prompted the exploration of alternative fertility control agents, particularly …
View article: Phytochemistry, Pharmacological Activities, and Drug Interactions of Pomegranate, Punica granatum L. (Punicaceae)
Phytochemistry, Pharmacological Activities, and Drug Interactions of Pomegranate, Punica granatum L. (Punicaceae) Open
Pomegranate (Punica granatum L.) is a Mediterranean plant that has been used in various countries for the treatment of various diseases in traditional medicine for many generations. These reported medicinal properties of pomegranate are ma…
View article: A Review on the anti-hyperglycaemic potential of Catharanthus roseus and Portulacaria afra
A Review on the anti-hyperglycaemic potential of Catharanthus roseus and Portulacaria afra Open
Diabetes mellitus is a prevalent non-communicable disease affecting individuals in developed and developing countries. However, low-income countries face significant challenges in managing diabetes due to socio-economic factors resulting i…
View article: A review of the pharmacodynamic effect of chemo-herbal drug combinations therapy for cancer treatment
A review of the pharmacodynamic effect of chemo-herbal drug combinations therapy for cancer treatment Open
There is mounting evidence that cancer patients co-administer herbal drugs with chemotherapy, however, information on the pharmacodynamic (PD) effects of such combination therapy is scarce. Natural products including crude extracts, herbal…
View article: Editorial: Metabolism of anti-cancer drugs: Interplay involving pharmacology and pharmacokinetics
Editorial: Metabolism of anti-cancer drugs: Interplay involving pharmacology and pharmacokinetics Open
EDITORIAL article Front. Oncol., 29 July 2022Sec. Pharmacology of Anti-Cancer Drugs Volume 12 - 2022 | https://doi.org/10.3389/fonc.2022.972718
View article: Phytochemical Profile, Safety and Efficacy of a Herbal Mixture Used for Contraception by Traditional Health Practitioners in Ngaka Modiri Molema District Municipality, South Africa
Phytochemical Profile, Safety and Efficacy of a Herbal Mixture Used for Contraception by Traditional Health Practitioners in Ngaka Modiri Molema District Municipality, South Africa Open
The use of medicinal plants for contraception remains a common practice among South African ethnic groups. The present study assessed the phytochemical profile, cytotoxicity, acute oral toxicity and efficacy of a herbal mixture used for co…
View article: Preclinical Assessment Addressing Intravenous Administration of a [68Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution
Preclinical Assessment Addressing Intravenous Administration of a [68Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution Open
It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicit…
View article: Application of a real-time cell analysis system in the process development and quantification of Rift Valley fever virus clone 13
Application of a real-time cell analysis system in the process development and quantification of Rift Valley fever virus clone 13 Open
Conventional cell-culture viral quantification methods, namely viral plaque and 50 % tissue culture infective dose assays, are time-consuming, subjective and are not suitable for routine testing. The viral plaque formation assay is the mai…
View article: In vivo evaluation of acute intravenous toxicity of a [68Ga]Ga-PSMA-11- microemulsion
In vivo evaluation of acute intravenous toxicity of a [68Ga]Ga-PSMA-11- microemulsion Open
Microemulsions (MEs) are reported to improve the efficacy of a drug, minimise side effects and toxicity of the encapsulated compound. MEs are hypothesized to aid in making the encapsulated compound, which has been incorporated within the M…
View article: Development and Evaluation of a Reconstitutable Dry Suspension Containing Isoniazid for Flexible Pediatric Dosing
Development and Evaluation of a Reconstitutable Dry Suspension Containing Isoniazid for Flexible Pediatric Dosing Open
Tuberculosis (TB) is a major cause of childhood death. Despite the startling statistics, it is neglected globally as evidenced by treatment and clinical care schemes, mostly extrapolated from studies in adults. The objective of this study …
View article: Development and validation of an LC-MS/MS method for the quantification of goserelin in a Pheroid® formulation, in simulated intestinal fluid
Development and validation of an LC-MS/MS method for the quantification of goserelin in a Pheroid® formulation, in simulated intestinal fluid Open
The purpose of this reported study was to develop and validate an LC-MS/MS method for the quantification of goserelin in a Pheroid® formulation simulated intestinal fluid. Biopharmaceuticals are formulated in drug delivery systems to impro…
View article: Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at Once Weekly Administration for the Duration of Treatment
Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at Once Weekly Administration for the Duration of Treatment Open
Aiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy over several months, we investigated whether nanoencapsulation of existing drugs would allow decreasing the treatment frequency to weekly, thereby ult…
View article: Functionalization of PLGA Nanoparticles with 1,3-β-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages
Functionalization of PLGA Nanoparticles with 1,3-β-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages Open
View article: Bioaccumulation and Subchronic Toxicity of 14 nm Gold Nanoparticles in Rats
Bioaccumulation and Subchronic Toxicity of 14 nm Gold Nanoparticles in Rats Open
Colloidal suspensions of 14 nm gold nanoparticles (AuNPs) were repeatedly administered intravenously at three dose levels (0.9, 9 and 90 µg) to male Sprague Dawley rats weekly for 7 weeks, followed by a 14-day washout period. After sacrifi…
View article: Inactivation of<i>Anopheles gambiae</i>Glutathione Transferase<i>ε</i>2 by Epiphyllocoumarin
Inactivation of<i>Anopheles gambiae</i>Glutathione Transferase<i>ε</i>2 by Epiphyllocoumarin Open
Glutathione transferases (GSTs) are part of a major family of detoxifying enzymes that can catalyze the reductive dehydrochlorination of dichlorodiphenyltrichloroethane (DDT). The delta and epsilon classes of insect GSTs have been implicat…
View article: Erratum to: Curdlan-conjugated PLGA Nanoparticles possess macrophage stimulant activity and drug delivery capabilities
Erratum to: Curdlan-conjugated PLGA Nanoparticles possess macrophage stimulant activity and drug delivery capabilities Open
View article: Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in&nbsp;human red blood cell loss in mice
Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice Open
Tafenoquine (TQ), a new synthetic analog of primaquine, has relatively poor bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. A microemulsion formulation of TQ (MTQ) with sizes <20 n…