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View article: 3D printing of radioactive wall-less PET phantoms improves threshold-based target delineation and quantification
3D printing of radioactive wall-less PET phantoms improves threshold-based target delineation and quantification Open
Background Validation of threshold-based PET segmentation and PET quantification is typically performed with fillable phantoms. Theoretical considerations show that the inactive walls of the phantom cavities introduce a contrast dependence…
View article: Proliferation and apoptosis after whole-body irradiation: longitudinal PET study in a mouse model
Proliferation and apoptosis after whole-body irradiation: longitudinal PET study in a mouse model Open
Purpose A reliable method for regional in vivo imaging of radiation-induced cellular damage would be of great importance for the detection of therapy-induced injury to healthy tissue and the choice of adequate treatment of radiation emerge…
View article: Dose- and application route-dependent effects of betahistine on behavioral recovery and neuroplasticity after acute unilateral labyrinthectomy in rats
Dose- and application route-dependent effects of betahistine on behavioral recovery and neuroplasticity after acute unilateral labyrinthectomy in rats Open
Introduction Betahistine is widely used for the treatment of various vestibular disorders. However, the approved oral administration route and maximum daily dose are evidently not effective in clinical trials, possibly due to a major first…
View article: Longitudinal Studies on Alzheimer Disease Mouse Models with Multiple Tracer PET/CT: Application of Reduction and Refinement Principles in Daily Practice to Safeguard Animal Welfare during Progressive Aging
Longitudinal Studies on Alzheimer Disease Mouse Models with Multiple Tracer PET/CT: Application of Reduction and Refinement Principles in Daily Practice to Safeguard Animal Welfare during Progressive Aging Open
Longitudinal studies on mouse models related to Alzheimer disease (AD) pathology play an important role in the investigation of therapeutic targets to help pharmaceutical research in the development of new drugs and in the attempt of an ea…
View article: Non-invasive in vivo imaging of porcine islet xenografts in a preclinical model with [68Ga]Ga-exendin-4
Non-invasive in vivo imaging of porcine islet xenografts in a preclinical model with [68Ga]Ga-exendin-4 Open
Introduction Islet xenotransplantation may be a therapeutic option in type 1 diabetes. Recent advances in generating genetically modified source pigs offer advantages as immune suppressants can potentially be eliminated after the transplan…
View article: Structural and Functional Neuroplasticity Following Bilateral Vestibular Loss: A Longitudinal [18F]-UCB-H/[18F]-FDG Dual Tracer Rat Study
Structural and Functional Neuroplasticity Following Bilateral Vestibular Loss: A Longitudinal [18F]-UCB-H/[18F]-FDG Dual Tracer Rat Study Open
Neuronal lesions trigger mechanisms of structural and functional neuroplasticity, which can support recovery. However, the temporal and spatial appearance of structure-function changes and their interrelation remain unclear. The current st…
View article: Ginkgo biloba Extract EGb 761 Improves Vestibular Compensation and Modulates Cerebral Vestibular Networks in the Rat
Ginkgo biloba Extract EGb 761 Improves Vestibular Compensation and Modulates Cerebral Vestibular Networks in the Rat Open
Unilateral inner ear damage is followed by behavioral recovery due to central vestibular compensation. The dose-dependent therapeutic effect of Ginkgo biloba extract EGb 761 on vestibular compensation was investigated by behavioral testing…
View article: Fully Automated Production and Characterization of <sup>64</sup>Cu and Proof‐of‐Principle Small‐Animal PET Imaging Using <sup>64</sup>Cu‐Labelled CA XII Targeting 6A10 Fab
Fully Automated Production and Characterization of <sup>64</sup>Cu and Proof‐of‐Principle Small‐Animal PET Imaging Using <sup>64</sup>Cu‐Labelled CA XII Targeting 6A10 Fab Open
64 Cu is a cyclotron‐produced radionuclide which offers, thanks to its characteristic decay scheme, the possibility of combining positron emission tomography (PET) investigations with radiotherapy. We evaluated the Alceo system from Comece…
View article: Systemic epidermal growth factor receptor-targeted gene delivery using the theranostic sodium iodide symporter (NIS) gene in an advanced orthotopic tumor model
Systemic epidermal growth factor receptor-targeted gene delivery using the theranostic sodium iodide symporter (NIS) gene in an advanced orthotopic tumor model Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)