Rosemary A. Aogo
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View article: Protective envelope dimer epitope–like antibodies are elicited against dengue virus in children after infection and vaccination
Protective envelope dimer epitope–like antibodies are elicited against dengue virus in children after infection and vaccination Open
Cross-reactive antibodies to epitopes that span envelope proteins on the virion surface are hypothesized to protect against dengue virus (DENV) infection and disease. Here, we measured antibodies targeting a quaternary epitope called the e…
View article: Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective
Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective Open
View article: High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines
High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines Open
View article: Primary exposure to Zika virus is linked with increased risk of symptomatic dengue virus infection with serotypes 2, 3, and 4, but not 1
Primary exposure to Zika virus is linked with increased risk of symptomatic dengue virus infection with serotypes 2, 3, and 4, but not 1 Open
Infection with any of the four dengue virus serotypes (DENV1–4) can protect against or enhance subsequent dengue depending on preexisting antibodies and infecting serotype. Additionally, primary infection with the related flavivirus Zika v…
View article: Envelope-dimer epitope-like broadly protective antibodies against dengue in children following natural infection and vaccination
Envelope-dimer epitope-like broadly protective antibodies against dengue in children following natural infection and vaccination Open
Cross-reactive antibodies (Abs) to epitopes that span envelope proteins on the virion surface are hypothesized to protect against dengue. Here, we measured Abs targeting the quaternary envelope dimer epitope (EDE) as well as neutralizing a…
View article: Dengue virus IgG and serotype-specific neutralizing antibody titers measured with standard and mature viruses are associated with protection
Dengue virus IgG and serotype-specific neutralizing antibody titers measured with standard and mature viruses are associated with protection Open
View article: Primary exposure to Zika virus increases risk of symptomatic dengue virus infection with serotypes 2, 3, and 4 but not serotype 1
Primary exposure to Zika virus increases risk of symptomatic dengue virus infection with serotypes 2, 3, and 4 but not serotype 1 Open
Infection with any of the four dengue virus serotypes (DENV1-4) can protect against or enhance subsequent dengue depending on pre-existing antibodies and the subsequent infecting serotype. Additionally, primary infection with the related f…
View article: Severe dengue progression beyond enhancement
Severe dengue progression beyond enhancement Open
View article: High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines
High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines Open
View article: Effects of boosting and waning in highly exposed populations on dengue epidemic dynamics
Effects of boosting and waning in highly exposed populations on dengue epidemic dynamics Open
Sequential infection with multiple dengue virus (DENV) serotypes is thought to induce enduring protection against dengue disease. However, long-term antibody waning has been observed after repeated DENV infection. Here, we provide evidence…
View article: Phase 1 trial to model primary, secondary, and tertiary dengue using a monovalent vaccine
Phase 1 trial to model primary, secondary, and tertiary dengue using a monovalent vaccine Open
View article: Fishing for novel dengue broadly neutralizing antibodies
Fishing for novel dengue broadly neutralizing antibodies Open
Due to a patent filing, the content of this abstract is not available to be shared at this time. The abstract will be shared at the poster session. This work was supported by the Intramural Research Program of the National Institute of All…
View article: The role of immune boosting and waning in shaping dengue epidemic dynamics
The role of immune boosting and waning in shaping dengue epidemic dynamics Open
Infection with one of the four dengue viruses (DENV1-4) induces both virus-specific and broadly reactive antibodies that may either provide protection or increase the severity of disease during secondary infection. Re-exposure in those wit…
View article: Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice
Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice Open
View article: Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity
Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity Open
Influenza viruses cause a significant amount of morbidity and mortality. Understanding host immune control efficacy and how different factors influence lung injury and disease severity are critical. We established and validated dynamical c…
View article: COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes
COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes Open
To understand the diversity of immune responses to SARS-CoV-2 and distinguish features that predispose individuals to severe COVID-19, we developed a mechanistic, within-host mathematical model and virtual patient cohort. Our results sugge…
View article: Author response: Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity
Author response: Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity Open
View article: COVID-19 virtual patient cohort reveals immune mechanisms driving disease outcomes
COVID-19 virtual patient cohort reveals immune mechanisms driving disease outcomes Open
To understand the diversity of immune responses to SARS-CoV-2 and distinguish features that predispose individuals to severe COVID-19, we developed a mechanistic, within-host mathematical model and virtual patient cohort. Our results indic…
View article: Leveraging Computational Modeling to Understand Infectious Diseases
Leveraging Computational Modeling to Understand Infectious Diseases Open
Computational modeling is now more than ever at the forefront of infectious disease research due to the COVID-19 pandemic. This review highlights how infectious diseases can be better understood by connecting scientists from medicine and m…
View article: Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells
Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells Open
Plasmodium parasites invade and multiply inside red blood cells (RBC). Through a cycle of maturation, asexual replication, rupture and release of multiple infective merozoites, parasitised RBC (pRBC) can reach very high numbers in vivo, a …
View article: Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice
Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice Open
View article: Within‐host modeling of blood‐stage malaria
Within‐host modeling of blood‐stage malaria Open
Summary Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmodium falciparum , is increasing in South East Asia. Control measures including novel drugs and vaccin…
View article: Modelling the role of HIV and its treatment in non-Hodgkin lymphoma growth dynamics
Modelling the role of HIV and its treatment in non-Hodgkin lymphoma growth dynamics Open
View article: Controlling African Trypanosomiasis in Livestock in Proximity to Wildlife
Controlling African Trypanosomiasis in Livestock in Proximity to Wildlife Open
African trypanosomiasis is a disease that affects humans and livestock. It is a protozoan disease that is spread by the tsetse fly. Nagana, as the disease is called in cattle, causes lethargy, wasting and death if untreated. The disease is…